Benzo[a]pyrene-induced up-regulation of circ_0003552 via ALKBH5-mediated mA modification promotes DNA damage in human bronchial epithelial cells.

Benzo [a]pyrene (B [a]P) is a widespread environmental chemical pollutant that has been linked to the development of various diseases. However, the specific mechanism of action remains unclear. In this study, human bronchial epithelial 16HBE and BEAS-2B cells were exposed to B [a]P at 0-32 μM to assess the DNA-damaging effects.

Directionally duplexed all-dielectric metalens for multifunctional structured light generation.

Directionally duplexed metalenses manipulated by the geometric phase of a silicon nano-bar are theoretically designed to generate multifunctional structured light. It is numerically demonstrated that incident light with different linear and circular polarization states, along forward and backward propagation directions, can be differentially converted into multiple focusing structured beams of arbitrary topological charges, either of vector light with azimuthally variant polarizations or of vortex light with helical phases. Due to the all-silicon and nonresonant metastructural design, the resultant high working efficiencies of our proposed metalens are promising for applications such as optical communication, nanoparticle manipulation, and other direction-duplexed multifunctional optical meta-devices.

Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis-mediated ATP efflux.

Purpose: Sepsis is characterized by an acute inflammatory response to infection, often with multiple organ failures, especially severe lung injury. This study was implemented to probe circular RNA (circRNA) protein tyrosine kinase 2 (circPTK2)-associated regulatory mechanisms in septic acute lung injury (ALI).

Methods: A cecal ligation and puncture-based mouse model and an lipopolysaccharides (LPS)-based alveolar type II cell (RLE-6TN) model were generated to mimic sepsis.

The involvement of copper, circular RNAs, and inflammatory cytokines in chronic respiratory disease.

Exposure to high concentrations of copper is associated with pulmonary inflammation and chronic respiratory disease (CRD). Epigenetic modulation of noncoding RNAs contributes to the development of several CRDs. It is unknown whether epigenetic modulation is involved in copper mediated pulmonary inflammation and CRD.

Identification of the function and regulatory network of circ_009773 in DNA damage induced by nanoparticles of neodymium oxide.

The health hazards of nanoparticles of neodymium oxide (NPs-NdO) have aroused public concern in recent years. Exposure to NPs-NdO can change the level of reactive oxygen species (ROS) that cause DNA damage and alter whole transcriptome expression profiles for micro (mi)RNA, circular (circ)RNA, long noncoding (lnc)RNA, and mRNA. However, there have been no reports to our knowledge about the role of circRNAs in DNA damage caused by NPs-NdO.

Circular RNA circ_Cabin1 promotes DNA damage in multiple mouse organs via inhibition of non-homologous end-joining repair upon PM exposure.

Fine particulate matter (PM) has been shown to induce DNA damage. Circular RNAs (circRNAs) have been implicated in various disease processes related to environmental chemical exposure. However, the role of circRNAs in the regulation of DNA damage response (DDR) after PM exposure remains unclear.

miR-30c-5p acts as a therapeutic target for ameliorating myocardial ischemia-reperfusion injury.

Coronary heart disease (CHD) is one of the most vital reasons for death and disability all over the world. miRNA, as a plasma index, is quite valuable for disease screening and prognosis prediction in CHD. Mining the molecular mechanism behind miRNA is also helpful for us to find molecular therapeutic strategies.

HPO enhanced catalytic activity of N, S, B, and O-codoped carbon nanosphere-armored CoS nanoparticles for organic pollutants degradation peroxymonosulfate activation: critical roles of superoxide radical, singlet oxygen and electron transfer.

In this study, we report a facile synthesis of a novel N, S, B, and O-codoped carbon nanosphere-armored Co9S8 nanoparticle composite (Co9S8@NSBOC) and its superior activation performance toward peroxymonosulfate (PMS) for methylene blue (MB) and ofloxacin degradation. The effects of various experimental parameters and the general applicability of the catalyst were investigated. Particularly, Co9S8@NSBOC exhibited high catalytic activity in a wide pH range of 3-12 and HPO42- exhibited a synergic catalytic effect with Co9S8@NSBOC in the degradation system.

Surface acidity and basicity of Mg/Al hydrotalcite for 2, 4-dichlorophenoxyacetic acid degradation with ozone: Mineralization, mechanism, and implications to practical water treatment.

The Mg/Al hydrotalcite (Mg/Al HT) was firstly used as a heterogeneous ozonation catalyst and 2,4-dichlorophenoxyacetic acid (2,4-D) was efficiently degraded by Mg/Al HT with a COD removal of 68 %. It was higher than that of α-FeOOH with a COD removal of 50 %. The effects of Mg/Al atomic ratio, phosphate and pyrrole on the ozonation performance of Mg/Al HTs were also investigated.

Circular RNA circBbs9 promotes PM-induced lung inflammation in mice via NLRP3 inflammasome activation.

Fine particulate matter (PM) is one of the most important components of environmental pollutants, and is associated with pulmonary injury. However, the biological mechanisms of pulmonary damage caused by PM are poorly defined, especially the molecular pathways related to inflammation. Following system exposure to PM for 3 months in normal mice and in chronic obstructive pulmonary disease (COPD) model mice, it was found that PM exposure increased the expression of IL-1β and IL-18 in lung tissues via NLRP3 activation, and these effects were more intense in COPD model mice.

Co nanoparticle-embedded N,O-codoped porous carbon nanospheres as an efficient peroxymonosulfate activator: singlet oxygen dominated catalytic degradation of organic pollutants.

In this study, Co nanoparticle-embedded N,O-codoped porous carbon nanospheres (C@Co) with abundant N and O doping, high graphitization, large specific surface area (319 m g) and a well-developed mesoporous structure were synthesized and characterized thoroughly, and were applied to activate peroxymonosulfate (PMS) for the degradation of methylene blue (MB). Various influential factors affecting the catalytic performance including C@Co dosage, PMS dosage, MB concentration, initial pH, temperature, and co-existing common anions and humic acid (HA) on the MB degradation were systematically investigated. The increase of the C@Co dosage (15-60 mg), PMS dosage (25-100 mg) and reaction temperature (278-308 K) promoted the MB degradation in the C@Co/PMS system.

Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells.

Background: Lung cancer has high morbidity and mortality worldwide with non-small cell lung cancer (NSCLC) accounting for 85% of the cases. Therapies for lung cancer have relatively poor outcomes and further improvements are required. Circular RNAs have been reported to participate in the occurrence and progression of cancer.

Circular RNA 406961 interacts with ILF2 to regulate PM-induced inflammatory responses in human bronchial epithelial cells via activation of STAT3/JNK pathways.

Fine particulate matter (PM) has been verified to augmented the incidence of pneumonia, asthma, pulmonary fibrosis, and other pulmonary diseases. Airway inflammation is the pathological basis of the respiratory system, and understanding the molecular mechanisms responsible for airway inflammation may thus support the diagnosis and treatment of respiratory diseases. In our study, human bronchial epithelial cells (BEAS-2B) were exposed to various concentrations of PM for 48 h.

CircRNA104250 and lncRNAuc001.dgp.1 promote the PM-induced inflammatory response by co-targeting miR-3607-5p in BEAS-2B cells.

Long-term exposure to particulate matter 2.5 (PM) is closely related to the occurrence and development of airway inflammation. Exploration of the role of PM in inflammation is the first step towards clarifying the harmful effects of particulate pollution.

Stem cell-derived extracellular vesicles for myocardial infarction: a meta-analysis of controlled animal studies.

Stem cell-derived extracellular vesicles (EVs) have emerged as a promising therapy for myocardial infarction, but its effects remain incompletely understood. We aim to systematically review the efficacy of EVs on myocardial infarction in both small and large animals.On April 5, 2018, we searched the PubMed, Embase and Web of Science databases using variations of "myocardial infarction" and "extracellular vesicle".

ST-segment elevation and the Tpeak-Tend/QT ratio predict the occurrence of malignant arrhythmia events in patients with vasospastic angina.

Background: ST-segment elevation (STE) and an increased Tpeak-Tend interval (Tp-e) have prognostic value for malignant arrhythmia events (MAEs) in patients with ST-segment elevation myocardial infarction (STEMI) and Brugada syndrome. Whether STE could predict MAEs and has an electrophysiological relationship with Tp-e in electrocardiogram (ECG) of vasospastic angina (VA) patients needs to be elucidated.

Methods: Sixty-five patients with VA and 23 patients with VA complicated by MAEs were enrolled.

Tpeak-Tend/QT interval predicts ST-segment resolution and major adverse cardiac events in acute ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention.

Elevated ST-segment and increased Tpeak-Tend interval (Tp-e) were prognostic predictors in major adverse cardiac events (MACEs) in ST-segment elevation myocardial infarction (STEMI). The electrophysiologic relationship between them during percutaneous coronary intervention (PCI) needs to elucidate.Patients with STEMI admitted to hospital were prospectively evaluated.

Heart Failure with Preserved Ejection Fraction Trials Have Heterogeneous Control Groups: a Comparison of Kaplan-Meier Curves.

Purpose: Previous studies have evaluated intra-study heterogeneities of heart failure with preserved ejection fraction (HFpEF), but inter-study heterogeneities remain poorly understood. We investigate the heterogeneities of outcomes among control groups of HFpEF trials.

Methods: We included randomized controlled trials recruiting HFpEF patients with ejection fraction ≥ 40% and reporting Kaplan-Meier curves for at least 36 months.