Publications by authors named "Jialing Mu"
Article Synopsis
- - Chronic kidney disease (CKD) is a significant public health issue in China, particularly impacting women, and the study investigates genetic factors affecting renal function using a more accurate measurement method, eGFR based on both creatinine and cystatin C.
- - A Genome-Wide Association Study (GWAS) involving 1,983 Chinese women analyzed over 3.8 million genetic variants to explore their relationship with eGFRcr-cys, revealing one significant locus and two new suggestive loci linked to renal function.
- - The research identified three critical genetic variants associated with eGFRcr-cys, providing new insights into the biological mechanisms affecting kidney health and potential avenues for better diagnoses and treatments for CKD in the
Hypertension (HT) is a major risk factor for cardiovascular diseases. Krüppel-like factors (KLFs) are important transcription factors in eukaryotes. Studies have reported that KLF4 and KLF5 are correlated with several cardiovascular diseases, but population-based studies on associations between HT and KLF4 or KLF5 have rarely been reported.
View Article and Find Full Text PDFBackground: Long noncoding RNA (lncRNA) and mRNA profiles in leukocytes have shown potential as biomarkers for acute ischemic stroke (AIS). This study aimed to identify altered lncRNA and target mRNA profiles in peripheral blood leukocytes as biomarkers and to assess the diagnostic value and association with AIS prognosis.
Methods And Results: Differentially expressed lncRNAs (DElncRNAs) and differentially expressed target mRNAs (DEmRNAs) were screened by RNA sequencing in the discovery set, which consisted of 10 patients with AIS and 20 controls.
Background: Dyslipidemia and inflammation are significant factors for the onset of cardiovascular diseases (CVD); however, studies regarding their interactions on the risk of CVD are scarce. This study aimed to assess the interaction of dyslipidemia and high-sensitivity C-reactive protein (hs-CRP) on CVD.
Methods: This prospective cohort enrolled 4,128 adults at baseline in 2009 and followed them up until May 2022 for collecting CVD events.
To explore the influence of age on hs-CRP among men and women and investigate the impact of hs-CRP on all-cause death, this prospective cohort enrolled 4128 community adults from 2009 to 2022 for all-cause death. Age and sex-specific hs-CRP percentile curves were generated using the GAMLSS method. Cox-proportional hazard regression analysis was applied to estimate the hazard ratios (HRs) and 95 % confidence intervals (CIs).
View Article and Find Full Text PDFThe relationship between lipid risk score and new-onset hypertension in a prospective cohort study.
Front Endocrinol (Lausanne)
October 2022
Article Synopsis
- The study analyzed the connection between dyslipidemia (abnormal lipid levels) and the development of hypertension (high blood pressure) over a span of more than 10 years involving 2,116 non-hypertensive participants.
- Researchers created a lipid risk score by evaluating various lipid measurements (like cholesterol and triglycerides) to assess its predictive ability for new hypertension cases.
- Findings revealed that higher lipid risk scores significantly increased hypertension risk, particularly in individuals under 55, emphasizing the importance of effective lipid management in preventing high blood pressure and cardiovascular issues.
Background: Thrombospondin-1 (THBS1) derived from platelets and acted as a critical mediator of hemostasis promoting platelet activation in thrombus formation. The biological connection of genetic variants and mRNA expression of with ischemic stroke (IS) warrants further validation with population-based evidence.
Objective: To evaluate the association of single nucleotide polymorphisms (SNPs) and mRNA expression of with the risks of IS and long-term death after stroke.