Publications by authors named "Jialing Dong"
Article Synopsis
- The study investigates how high salt intake influences the progression of autoimmune diseases, specifically type 1 diabetes, using nonobese diabetic (NOD) mice as models.
- Findings indicate that a high-salt diet (HSD) accelerates diabetes development and worsens autoimmune responses, notably through a mechanism involving CD4+ T cells.
- The research highlights the critical role of SPAK, a protein that appears to be key in linking high salt consumption to increased T-cell activity and diabetes severity, suggesting potential therapeutic avenues targeting SPAK might mitigate this effect.
Article Synopsis
- Positive regulatory domain 1 (PRDM1) encodes Blimp-1, a key regulator that helps maintain T cell balance and has been shown to suppress autoimmune responses in the presence of overexpression.
- The study highlights a significant negative relationship between Blimp-1 and IL-21, revealing that Blimp-1 reduces IL-21 production by altering chromatin accessibility and disrupting c-Maf, an activator of IL-21.
- Blocking IL-21 enhances the protective effects of Blimp-1 against autoimmune conditions like colitis, demonstrating potential therapeutic avenues for managing autoimmune diseases through understanding and manipulating the Blimp-1/IL-21 feedback loop.
Autoimmunity is a complex and multifaceted process that contributes to widespread functional decline that affects multiple organs and tissues. The pandemic of autoimmune diseases, which are a global health concern, augments in both the prevalence and incidence of autoimmune diseases, including type 1 diabetes, multiple sclerosis, and rheumatoid arthritis. The development of autoimmune diseases is phenotypically associated with gut microbiota-modulated features at the molecular and cellular levels.
View Article and Find Full Text PDFInflammatory colon diseases, which are a global health concern, include a variety of gastrointestinal tract disorders, such as inflammatory bowel disease and colon cancer. The pathogenesis of these colon disorders involves immune alterations with the pronounced infiltration of innate and adaptive immune cells into the intestines and the augmented expression of mucosal pro-inflammatory cytokines stimulated by commensal microbiota. Epidemiological studies during the past half century have shown that the proportion of obese people in a population is associated with the incidence and pathogenesis of gastrointestinal tract disorders.
View Article and Find Full Text PDFAn efficient three-component coupling reaction toward a variety of furan derivatives has been developed. This cascade transformation proceeds via the gold-catalyzed coupling reaction of phenylglyoxal derivatives, secondary amines, and terminal alkynes, under the reaction conditions, that undergoes cyclization into the furan core.
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