The Clinical Efficacy of Combining Ambroxol Hydrochloride with Antibiotics for the Treatment of Chronic Bronchitis.

Objective: To evaluate the clinical efficacy and impact on pulmonary function of ambroxol hydrochloride combined with antibiotics in the treatment of chronic bronchitis.

Methods: This randomized controlled trial involved the enrollment and randomization of 98 CB patients admitted to Anting Hospital from January 2020 to January 2021, with participants divided into an observation group and a control group at a 1:1 ratio, comprising 49 cases in each group. The control group received cefmetazole alone, whereas the observation group received ambroxol hydrochloride combined with antibiotics.

Knockdown of UbcH10 enhances the chemosensitivity of dual drug resistant breast cancer cells to epirubicin and docetaxel.

Breast cancer is one of the most common and lethal cancers in women. As a hub gene involved in a diversity of tumors, the ubiquitin-conjugating enzyme H10 (UbcH10), may also play some roles in the genesis and development of breast cancer. In the current study, we found that the expression of UbcH10 was up-regulated in some breast cancer tissues and five cell lines.

Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation.

Angiogenic therapy with individual growth factors or "master switch" genes is being evaluated for treatment of advanced coronary artery disease. In this study, we investigated the efficacy and mechanism of PR39, a gene capable of activating VEGF and fibroblast growth factor (FGF)-2-dependent pathways. PR39 enhances hypoxia-inducible factor-1alpha (HIF-1alpha)-dependent gene expression by selectively inhibiting proteasome degradation of this transcription factor.