Publications by authors named "Jialiang Xu"
Flexible molecular crystals are essential for advancing smart materials, providing unique functionality and adaptability for applications in next-generation electronics, pharmaceuticals, and energy storage. However, the optical applications of flexible molecular crystals have been largely restricted to linear optics, with nonlinear optical (NLO) properties rarely explored. Herein, we report on the application of mechanical twisting of flexible molecular crystals for second-order nonlinear optics.
View Article and Find Full Text PDFBackground: Antimicrobial resistance poses a significant threat to global health, with its spread intricately linked across human, animal, and environmental sectors. Revealing the antimicrobial resistance gene (ARG) flow among the One Health sectors is essential for better control of antimicrobial resistance.
Results: In this study, we investigated regional ARG transmission among humans, food, and the environment in Dengfeng, Henan Province, China by combining large-scale metagenomic sequencing with culturing of resistant bacterial isolates in 592 samples.
Chiral hybrid organic-inorganic metal halides (HOMHs) hold great promise in broad applications ranging from ferroelectrics, spintronics to nonlinear optics, owing to their broken inversion symmetry and tunable chiroptoelectronic properties. Typically, chiral HOMHs are constructed by chiral organic cations and metal anion polyhedra, with the latter regarded as optoelectronic active units. However, the primary design approaches are largely constrained to regulation of general components within structural formula.
View Article and Find Full Text PDFCarried by a Transferable Plasmid in a Strain Isolated from Healthy Individuals.
Biomed Environ Sci
November 2024
Objective: Our study aimed to conduct genomic characterization of strains carrying the gene in the intestinal tract of healthy individuals. The objectives were to underscore the importance of genomic surveillance for drug resistance in both commensal and pathogenic bacteria among healthy populations, and to establish protocols for regulating drug resistance plasmids based on the completion of a comprehensive map of drug resistance plasmid genomes.
Methods: We performed antimicrobial susceptibility testing and employed second- and third-generation sequencing techniques to analyze strains harboring the gene, to surveil drug-resistant bacteria in the intestines of healthy subjects.
Food workers have frequent contact with unprocessed foods, but their carriage of Salmonella and potential influence on public health have not been comprehensively assessed. We investigated Salmonella carriage among food workers compared with non-food workers based on occupational health screening of 260,315 asymptomatic workers over an 8-year surveillance period in Yulin, China. We confirmed that healthy carriers serve as natural reservoirs for Salmonella, with higher carriage rates in food workers than non-food workers.
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- Elderly patients with first acute myocardial infarction (AMI) often experience worse outcomes, and this study aimed to assess how comorbidities affect their prognosis.
- The study analyzed 479 elderly AMI patients categorized into three groups based on the number of comorbidities, revealing that those with more comorbidities had higher rates of complications and worse prognoses.
- The findings suggest that clinicians should consider comorbidity levels to better identify high-risk elderly patients and improve their management after AMI.
Background: Antimicrobial resistance (AMR) is one of the most pressing global public health challenges; in particular, the rapid dissemination of carbapenem-resistant Enterobacterales (CRE) is emerging as a significant concern worldwide. Flies, serving as carriers of pathogens, pose a potential threat in the transmission of antibiotic-resistant bacteria (ARB) between animals and humans. The aim of this study was to evaluate and reveal the potential risk of AMR spread by flies.
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- Researchers are exploring the significant shape changes in thermosalient materials, which have potential uses in actuators and sensors, but the mechanisms behind these changes remain unclear.
- A study has identified the order parameter for the phase transition in a specific molecular crystal, revealing that the transition barrier disappears at its transition temperature.
- The research combines computational simulations and experimental methods, showing that specific vibrational modes relate to the phase transition, and suggests that applying a computational THz pulse can induce this phase change quickly.
Article Synopsis
- Shape-controlled alloy nanoparticle catalysts improve performance in oxygen reduction reactions (ORR) in liquid half-cells, but face challenges in fuel cell applications due to harsher operating conditions.* -
- A new strategy was developed to limit atomic diffusion in surface layers, allowing for the selective transformation of platinum-iron nanowires into stable intermetallic structures at low temperatures.* -
- This surface engineering approach enhances membrane electrode assembly (MEA) stability by reducing iron loss by 50% while maintaining high catalytic activity, showing promise for practical fuel cell applications with shape-controlled catalysts.*
Peripheral nerve injury occurs in a relatively large proportion of trauma patients, in whom it generally results in severe functional impairment and permanent disability. At present, however, there are no effective treatments available. Studies have shown that Schwann cells play an indispensable role in removing myelin debris and guiding axonal regeneration, and transplantation using autologous Schwann cells has shown good efficacy for patients with peripheral nerve injury.
View Article and Find Full Text PDFLow-Temperature Flexibility of Chiral Organic Crystals with Highly Efficient Second-Harmonic Generation.
Angew Chem Int Ed Engl
September 2024
Article Synopsis
- Flexible chiral Schiff-base crystals exhibit unique mechanical properties and efficient second harmonic generation (SHG) capabilities, making them promising for applications in optoelectronics and sensors.
- These crystals retain their flexibility at both room temperature and 77 K, with enantiomers generating SHG intensities up to 12 times that of standard potassium dihydrogenphosphate (KDP).
- The study highlights the first instance of low-temperature-resistant flexible organic single-crystalline materials with nonlinear optical properties, paving the way for innovative advancements in mechanically flexible NLO materials.
Article Synopsis
- Dendritic cells (DCs) are essential for regulating immune responses in tumors, especially in clear-cell renal-cell carcinoma (ccRCC), but current research has gaps in understanding their role in immune activation.
- The study identified key genes related to activated DCs using RNA-seq data and developed a prognostic model that includes five specific genes, validated using several external data sets.
- This model not only predicts patient outcomes in advanced ccRCC but also shows associations with tumor progression and how patients might respond to therapies like the BET inhibitor JQ1.
Dynamic twisting crystals, combining the features of dynamic crystals and twisting crystals, promise advanced applications in targeted drug delivery, biosensors, microrobots, and spiral optoelectronics. However, the determination of dynamic twisting crystals with specific directions remains a formidable challenge in practical applications. Herein, based on organic-inorganic hybrid metal halide (OIHMH) single crystals, we have realized the chirality-induced macroscopic twisting of single crystals driven by a thermo-induced topochemical dehydration reaction.
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- Acne vulgaris is a common skin condition that affects many people, especially teenagers, and can have lasting physical and emotional effects.
- Recent overuse of antibiotics for acne has resulted in antibiotic-resistant bacteria, prompting the need for alternative treatments.
- A new bacteriophage was discovered and studied, showing it could be a safe and effective antibacterial treatment for acne, enhancing current therapies without contributing to antibiotic resistance.
Article Synopsis
- Previous studies hint at connections between the TERT gene, shorter telomere length in white blood cells, and cerebrovascular disease, but the specific links haven't been confirmed.
- Researchers analyzed TERT gene variations in 307 cerebrovascular disease patients and 320 healthy individuals, using genetic models to assess the relationship between these variations and the disease.
- Results showed two gene variations significantly associated with the disease, and further analysis suggested that shorter telomeres could be causally linked to a higher risk of cerebrovascular disease.
Article Synopsis
- The integration of spirocycles with buckybowls leads to the creation of unique three-dimensional curved π-systems with enhanced physicochemical properties due to the curved structure of buckybowls.
- Researchers synthesized carbon-bridged spiro-type heterosumanenes (spiro-HSEs) using 9,9'-spirobifluorene and dichalcogenasumanenes (DCSs), finding that spiro-conjugation significantly affects their geometric and electronic characteristics.
- The study explored selective transformations of spiro-HSEs based on the chalcogen atoms used (S, Se, Te), leading to functional enhancements such as improved emissive properties and the
Article Synopsis
- The tumor microenvironment (TME) significantly influences tumor behavior, and this study investigates how DNA methylation impacts TME in clear-cell renal cell carcinoma (ccRCC).
- Researchers identified four key methylation-driven genes (TME-MDGs) through DNA methylation and RNA-seq analysis, confirming their downregulation in tumor samples.
- The findings suggest these genes are linked to patient response to immunotherapy and targeted treatments like pazopanib, offering potential new targets for ccRCC therapies.
Objective: To investigate the prognostic performance of radiomics analysis of lesion-specific pericoronary adipose tissue (PCAT) for major adverse cardiovascular events (MACE) with the guidance of CT derived fractional flow reserve (CT-FFR) in coronary artery disease (CAD).
Materials And Methods: The study retrospectively analyzed 608 CAD patients who underwent coronary CT angiography. Lesion-specific PCAT was determined by the lowest CT-FFR value and 1691 radiomic features were extracted.
The further practical applications of Li-rich layered oxides are impeded by voltage decay and redox asymmetry, which are closely related to the structural degradation involving irreversible transition metal migration. It has been demonstrated that the superstructure ordering in O2-type materials can effectively suppress voltage decay and redox asymmetry. Herein, we elucidate that the absence of this superstructure ordering arrangement in a Ru-based O2-type oxide can still facilitate the highly reversible transition metal migration.
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- Microbial communities in river systems are key indicators of healthy ecosystems, yet there's a knowledge gap about how antibiotic resistance genes (ARGs) and human pathogens interact with the microbes found in these areas.
- This study used enrichment-based culturomics and metagenomics to explore the microbial diversity and ARG distribution in the Lancang River Source Basin, isolating 674 bacterial strains, including 30 that are relevant to human health.
- Findings revealed that the main antibiotic found was bacitracin, with a low-risk assessment for ARGs posing threats to human health, highlighting the effectiveness of culturomics in discovering rare bacteria.
Article Synopsis
- The study focuses on identifying and characterizing three new aerobic bacterial strains isolated from the baijiu fermentation environment, which includes many unexplored microorganisms.
- Strain REN20 and REN29 are Gram-negative bacteria, while strain REN33 is Gram-positive, with varying tolerances to temperature, pH, and salt concentration.
- The research suggests that these strains do not meet established genetic criteria for existing species, leading to the proposal of three new bacterial species based on comprehensive taxonomic analysis.
Background: Coronary artery disease (CAD) in type 2 diabetes mellitus (T2DM) patients often presents diffuse lesions, with extensive calcification, and it is time-consuming to measure coronary artery calcium score (CACS).
Objectives: To explore the predictive ability of deep learning (DL)-based CACS for obstructive CAD and hemodynamically significant CAD in T2DM.
Methods: 469 T2DM patients suspected of CAD who accepted CACS scan and coronary CT angiography between January 2013 and December 2020 were enrolled.
Article Synopsis
- * A new mechanism through charge transfer (CT) excited states from metal halide polyhedra to organic ligands is proposed to improve NLO performance significantly.
- * The study demonstrates that the model lead halide (CHN)PbBr achieves impressive second harmonic generation, with NLO coefficients that are much higher than traditional materials, paving the way for designing advanced chiral HOMH materials for photonic uses.
Article Synopsis
- Stimuli-responsive optical materials are key for developing advanced optoelectronic devices, with organic-inorganic hybrid metal halides as a promising base due to their structural diversity.* -
- A crown ether was used to modify a chiral antimony halide, enhancing its ability to produce self-trapped excitons, resulting in high photoluminescence (over 85%) and effective circularly polarized luminescence.* -
- These antimony halide enantiomers exhibit sensitive luminescent responses to changes in excitation wavelength and temperature, enabling reversible color switching from blue to white to orange, with potential applications in innovative lighting and sensing technologies.*
Article Synopsis
- Flexible crystals are gaining popularity due to their impressive flexibility and adaptability, which open up many research and application opportunities.
- The main challenges in this field involve the design, preparation, and optimization of these crystals, emphasizing the need for a better understanding of what makes them flexible.
- The article reviews the progress made in the last two decades, discusses the relationship between crystal elasticity and plasticity, and highlights new experimental methods for studying molecular interactions essential for advancing the understanding of crystal flexibility.