In-line hemofiltration minimized extracorporeal membrane oxygenation-related inflammation in a porcine model.

We evaluated a pattern for connecting a hemofiltration apparatus after the ECMO oxygenator and observed the effects on the levels of inflammatory cytokines. All animals were anesthetized and ventilated, were randomly divided into 3 groups and observed for 24 h: S group (n = 6) received cannulation and heparin infusion; E group (n = 6) received venovenous (VV)-ECMO and heparin infusion; E+H group (n = 6) received hemofiltration with VV-ECMO placed after the oxygenator and heparin infusion. Hemodynamics, gas exchange parameters and plasma cytokine levels were measured simultaneously.

Effects of continuous renal replacement therapy on renal inflammatory cytokines during extracorporeal membrane oxygenation in a porcine model.

Background: Extracorporeal membrane oxygenation (ECMO) has been recommended for the treatment of patients with acute, potentially reversible, life-threatening respiratory failure which unresponsive to conventional therapy. But it is unclear about how ECMO affects renal tissue.

Methods: Twenty-four piglets weighing 25 to 32 kg were used in this experiment.