Publications by authors named "Jiali Rao"
Article Synopsis
- Haematitum, a mineral medicine known to be toxic, was studied for its effects on organ damage in mice, highlighting that long-term or high-dose use can harm various organs, particularly the intestine, liver, spleen, and lungs.
- The study divided mice into groups based on different doses of Haematitum and calcined Haematitum, noting that low doses of Haematitum showed no toxicity, while high doses resulted in significant damage and calcined Haematitum was less toxic overall.
- Metabolomics technology revealed disruptions in lipid metabolism pathways, particularly related to lung toxicity, and indicated that high doses of Haematitum precipitated various organ damage, while low doses were safe.
Ethnopharmacological Relevance: Haematitum, a time-honored mineral-based Chinese medicine, has been used medicinally in China for over 2000 years. It is now included in the Chinese Pharmacopoeia and used clinically for treating digestive and respiratory diseases. The Chinese Materia Medica records that it is toxic and should not be taken for a long period, but there are few research reports on the toxicity of Haematitum and its potential toxicity mechanisms.
View Article and Find Full Text PDFThis study aimed to explore the active components and the effect of Hedyotis diffusa (HD) against Alzheimer's disease (AD) via network pharmacology, molecular docking, and experimental evaluations. We conducted a comprehensive screening process using the TCMSP, Swiss Target Prediction, and PharmMapper databases to identify the active components and their related targets in HD. In addition, we collected potential therapeutic targets of AD from the Gene Cards, Drugbank, and OMIM databases.
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