Publications by authors named "Jiali Gong"

Background: Adequate bowel preparation is crucial for effective colonoscopy, especially in elderly patients who face a high risk of inadequate preparation. This study develops and validates a machine learning model to predict bowel preparation adequacy in elderly patients before colonoscopy.

Methods: The study adhered to the TRIPOD AI guidelines.

View Article and Find Full Text PDF

Background: Programmed cell death 1/programmed death ligand-1 (PD-L1)-based immune checkpoint blockade is an effective treatment approach for non-small-cell lung cancer (NSCLC). However, immunohistochemistry does not accurately or dynamically reflect PD-L1 expression owing to its spatiotemporal heterogeneity. Herein, we assessed the feasibility of using a Ga-labeled anti-PD-L1 nanobody, Ga-NODAGA-NM-01, for PET imaging of PD-L1.

View Article and Find Full Text PDF

A novel molecular classification for small cell lung cancer (SCLC) has been established utilizing the transcription factors achaete-scute homologue 1 (ASCL1), neurogenic differentiation factor 1 (NeuroD1), POU class 2 homeobox 3 (POU2F3), and yes-associated protein 1 (YAP1). This classification was predicated on the transcription factors. Conversely, there is a paucity of information regarding the distribution of these markers in other subtypes of pulmonary neuroendocrine tumors (PNET).

View Article and Find Full Text PDF

Purpose: This study aimed to assess the feasibility and acceptability of a couple-based self-efficacy (SE) intervention, and to examine the effects of the intervention on health outcomes for CRC couples.

Methods: An assessor-blinded, two-armed, randomized controlled design was used. The study randomly assigned 144 patients hospitalized for colorectal cancer to receive either the SE intervention or the usual care.

View Article and Find Full Text PDF

Tumor immunotherapy represents a highly promising modality for the treatment of triple-negative breast cancer (TNBC). Nevertheless, its therapeutic efficacy has been profoundly impacted by challenges such as low drug uptake, hypoxia, and immunosuppression. To address these problems, the study develops a strategy combining sonodynamic therapy (SDT) and immunotherapy using biomimetic nanoparticles coated with hybrid membranes.

View Article and Find Full Text PDF

Plectin, a scaffolding protein overexpressed in tumor cells, plays a significant role in hepatocellular carcinoma (HCC) proliferation, invasion, and migration. However, the use of L-type peptides for targeting plectin is hindered by their limited stability and retention. We designed a D-type plectin-targeting peptide (PTP) and developed a novel single-photon emission computed tomography (SPECT) probe for HCC imaging.

View Article and Find Full Text PDF
Article Synopsis
  • This study explored the unclear causal relationship between immune cells and chronic lymphatic leukemia (CLL).
  • Researchers used extensive genetic data from public databases and employed advanced analytical methods, including Mendelian randomization techniques, to analyze potential links.
  • Results indicated significant causal connections between five specific immune cell types and CLL, confirming the importance of immune cells in the development of the disease.
View Article and Find Full Text PDF

Introduction: Individuals who develop new-onset diabetes have been identified as a high-risk cohort for pancreatic cancer (PC), exhibiting an incidence rate nearly 8 times higher than the general population. Hence, the targeted screening of this specific cohort presents a promising opportunity for early pancreatic cancer detection. We aimed to develop and validate a novel model capable of identifying high-risk individuals among those with new-onset diabetes.

View Article and Find Full Text PDF

A rise in blood glucose is an early warning sign of underlying pancreatic cancer (PC) and may be an indicator of genetic events in PC progression. However, there is still a lack of mechanistic research on pancreatic cancer-associated new-onset diabetes (PCAND). In the present study, we identified a gene SRI, which possesses a SNP with the potential to distinguish PCAND and Type 2 diabetes mellitus (T2DM), by machine learning on the basis of the UK Biobank database.

View Article and Find Full Text PDF

Background: In radiotherapy, the delineation of the gross tumor volume (GTV) in brain metastases using computed tomography (CT) simulation localization is very important. However, despite the criticality of this process, a pronounced gap exists in the availability of tools tailored for the automatic segmentation of the GTV based on CT simulation localization images.

Purpose: This study aims to fill this gap by devising an effective tool specifically for the automatic segmentation of the GTV using CT simulation localization images.

View Article and Find Full Text PDF

Neutralizing antibodies (NtAbs) against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are indicators of vaccine efficacy that enable immunity surveillance. However, the rapid mutation of SARS-CoV-2 variants prevents the timely establishment of standards required for effective XBB vaccine evaluation. Therefore, we prepared four candidate standards (No.

View Article and Find Full Text PDF

Purpose: To evaluate the clinical effects of a couple-focused dyadic coping intervention in colorectal cancer (CRC) couples.

Methods: The study was a single-blinded randomized controlled study which 226 CRC couples were recruited and randomized to either the intervention (N = 113) or the control (N = 113) group. All couples received usual care while the six-week dyadic coping intervention was provided to the intervened couples in psycho-education and skill training methods through face-to-face combined with telephone formats.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how genetic characteristics of bone metastasis (BM) in non-small-cell lung cancer (NSCLC) affect patients' outcomes and identifies potential therapeutic targets.
  • The research involved analyzing genomic data from primary tumors and BMs in a group of patients, utilizing next-generation sequencing (NGS) to identify differences in genetic composition.
  • Results showed an increase in gene amplification in BMs and a correlation between high gene expression and poorer survival rates, highlighting the need for further research into targeted therapies.
View Article and Find Full Text PDF

Background: Under the guidance of a preliminary Live with Love Conceptual Framework, a Caring for Couples Coping with Colorectal Cancer (4Cs: CRC) programme was designed specifically for colorectal cancer couples. The objectives of this study included examining the efficacy of the programme for couples adapting to colorectal cancer and comparing the effects of different intervention delivery modes (online, face-to-face and blended) on couple outcomes.

Methods: A four-arm randomized controlled trial was conducted among Chinese colorectal cancer couples.

View Article and Find Full Text PDF

Objectives: To explore the dyadic interdependence of self-efficacy, benefit finding, anxiety, depression, and QOL in cancer patient (CP) and family caregiver (FC) dyads, and to ascertain the dyadic effects of self-efficacy on quality of life (QOL) in CP-FC dyads.

Methods: Conducted from November 2014 to December 2015, participants comprised 772 CP-FC dyads. The study surveyed participant characteristics, self-efficacy, benefit finding, anxiety, depression, and QOL.

View Article and Find Full Text PDF

Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a recently described smoking-related malignancy. The pathogenesis of SMARCA4-UT is the mutational inactivation and loss of expression of a subunit encoding the mammalian switch/sucrose nonfermenting ATPase-dependent chromatin remodeling complex (which can be mobilized using adenosine triphosphate hydrolysis nucleosomes and regulate other cellular processes including development, differentiation, proliferation, and apoptosis), in particular SMARCA4 and SMARCA2. The dynamic activity of this complex plays an important role in regulating the activation and repression of gene expression programs.

View Article and Find Full Text PDF

Purpose: The unique structure of nanobodies is advantageous for the development of radiopharmaceuticals for nuclear medicine. Nanobodies targeted to human epidermal growth factor receptor 2 (HER2) can be used as tools for the imaging and therapy of HER2-overexpressing tumors. In this study, we aimed to describe the generation of a I-labeled anti-HER2 nanobody as a targeted radionuclide therapy (TRNT) agent for HER2-positive breast cancer.

View Article and Find Full Text PDF

Peanut ( L.) is an important cash crop and oil crop around the world. In August 2021, symptoms of leaf spot were found on nearly 50% of peanut plants in the peanut planting base of Xuzhou Academy of Agriculture Sciences, Jiangsu, China.

View Article and Find Full Text PDF
Article Synopsis
  • This study explores a couples-based dyadic coping intervention for colorectal cancer couples, examining its feasibility, acceptability, and preliminary efficacy.
  • The intervention consisted of six sessions and showed strong recruitment and retention rates, indicating it is feasible and participants were satisfied with it.
  • Results showed small-to-medium effects on improving dyadic coping and cancer adaptation, suggesting the intervention may be effective, but larger trials are needed to confirm these findings.
View Article and Find Full Text PDF

Objective: This study aims to understand the experiences of colorectal cancer (CRC) patients and their spousal caregivers during the COVID-19 pandemic and to refine a self-efficacy (SE) intervention for these couples.

Methods: A descriptive phenomenological approach was used in this study. Data were collected from 11 CRC couples.

View Article and Find Full Text PDF

Pulmonary mucoepidermoid carcinoma (PMEC) is the most common malignant salivary gland tumor in the lungs and accounts for 0.1-0.2% of all lung malignancies in adults.

View Article and Find Full Text PDF

Postgraduate students are required to undertake a series of research assignments. Research self-efficacy is regarded as the sense of faith in their ability to accomplish research tasks. However, it is unclear how research self-efficacy plays a role in second-year nursing postgraduate students who have been enrolled for a period of time and have not yet met graduation requirements.

View Article and Find Full Text PDF

Objective: Both cancer survivors and caregivers often experience a range of problems and unmet needs during the post-treatment survivorship. Web-based dyadic interventions may be critical for cancer survivors and their caregivers. This article aims to systematically explore existing web-based dyadic interventions for post-treatment cancer survivors and caregivers in terms of intervention focus, content, delivery, and outcomes and to provide valuable recommendations for future research.

View Article and Find Full Text PDF
Article Synopsis
  • Certain receptors, like plectin, are often overexpressed in tumors and are linked to cancer progression, making them valuable targets for cancer imaging.
  • Researchers developed a plectin-targeted peptide (PTP) labeled with [Tc]Tc for use as a SPECT imaging probe and tested its effectiveness in mouse models.
  • The [Tc]Tc-HYNIC-PTP showed good compatibility, effective tumor targeting, stable imaging properties, and a correlation between its accumulation in tumors and plectin expression levels, indicating its potential as a cancer imaging tool.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionuj75ddsif84sbofdsqpg67p4057epdlk): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once