Research progress of nitroxide radical-based MRI contrast agents: from structure design to application.

Magnetic resonance imaging (MRI) remains a cornerstone of diagnostic imaging, offering unparalleled insights into anatomical structures and pathological conditions. Gadolinium-based contrast agents have long been the standard in MRI enhancement, yet concerns over nephrogenic systemic fibrosis have spurred interest in metal-free alternatives. Nitroxide radical-based MRI contrast agents (NO-CAs) have emerged as promising candidates, leveraging their biocompatibility and imaging capabilities.

Hyperbranched Polymeric F MRI Contrast Agents with Long Relaxation Time Based on β-Cyclodextrin and Phosphorycholine.

F magnetic resonance imaging (F MRI) is gaining attention as an emerging diagnostic technology. Effective F MRI contrast agents (CAs) for in vivo applications require a long transverse (or spin-spin) relaxation time (), short longitudinal (or spin-lattice) relaxation time (), high fluorine content, and excellent biocompatibility. Here, we present a novel hyperbranched polymeric F MRI CA based on β-cyclodextrin and phosphorylcholine.

A polymeric H/F dual-modal MRI contrast agent with a snowman-like Janus nanostructure.

Magnetic resonance imaging (MRI) has emerged as a pivotal tool in contemporary medical diagnostics, offering non-invasive and high-resolution visualization of internal structures. Contrast agents are essential for enhancing MRI resolution, accurate lesion detection, and early pathology identification. While gadolinium-based contrast agents are widely used in clinics, safety concerns have prompted exploration of metal-free alternatives, including fluorine and nitroxide radical-based MRI contrast agents.

Biomedical Application of Porphyrin-Based Amphiphiles and Their Self-Assembled Nanomaterials.

Porphyrins have been vastly explored and applied in many cutting-edge fields with plenty of encouraging achievements because of their excellent properties. As important derivatives of porphyrins, porphyrin-based amphiphiles (PBAs) not only maintain the advanced properties of porphyrins (catalysis, imaging, and energy transfer) but also possess self-assembly and encapsulation capability in aqueous solution. Accordingly, PBAs and their self-assembles have had important roles in diagnosing and treating tumors and inflammation lesions , but not limited to these.