Publications by authors named "Jiakui Ren"
Article Synopsis
- Neutrophils from skull bone marrow (N) infiltrate brain tissue rapidly and are characterized by high levels of osteocalcin (OCN) after traumatic brain injury (TBI).
- The transcription factor Fos-like 1 regulates specific genes in these neutrophils, impacting their antiapoptotic, proliferative, and immunosuppressive functions.
- The research suggests that targeting the CCRL2 gene could influence neutrophil recruitment and activity, highlighting their potential role in neuroprotection following TBI.
Article Synopsis
- Neutrophils play a complex role in traumatic brain injury (TBI), exhibiting both protective and damaging effects that vary over time.
- Researchers utilized advanced techniques such as single-cell transcriptomics and metabolomics to explore a specific neutrophil phenotype linked to TBI outcomes, revealing a significant involvement of the FOXO1 protein.
- FOXO1-expressing neutrophils were found to contribute to worsening inflammation and depression post-TBI by regulating apoptosis and disrupting iron balance in oligodendrocytes, indicating their dual role in brain injury management.
Blood-brain barrier (BBB) impairment and glutamate release are two pathophysiological features of traumatic brain injury (TBI), contributing to secondary brain damage and neuroinflammation. However, our knowledge of BBB integrity damage and dysfunction are still limited due to the diverse and fluctuating expression of glutamate receptors after trauma. Here, we confirmed the downregulation of metabotropic glutamate receptor 5 (mGluR5) on microvascular endothelial cell within the acute phase of TBI, and the recovered mGluR5 levels on BBB was positively associated with blood perfusion and neurological recovery.
View Article and Find Full Text PDFGiven the heterogeneity of solid tumors, single-target CAR-T cell therapy often leads to recurrence, especially in ovarian cancer (OV). Here, we constructed a Tandem-CAR targeting two antigens with secretory activity (IL-12) to improve the effects of CAR-T cell therapy. Twenty coexpressed upregulated genes were identified from the GEO database, and we found FOLR1 (folate receptor 1) and MSLN (mesothelin) were specifically and highly expressed in cancer tissues and only 11.
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