Publications by authors named "Jiajun Zhu"

Diabetic wounds are a leading cause of disability and mortality in patients with diabetes, and persistent low-grade inflammation plays a significant role in their pathogenesis. Methylglyoxal (MGO), an active product of glucose metabolism, often induces chronic inflammation and is considered a major risk factor in the healing of diabetic wounds. Efferocytosis, the process by which macrophages clear apoptotic cells, is crucial for terminating the inflammatory response and tissue repair.

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Film components have been progressively included in thermal battery due to their unique volume and performance superiority. With poor thermal stability, organic adhesives in film will decompose at operation temperature, generating gas within the battery shell. Considering structural integrity, organic adhesives in film components cannot be completely eliminated in prior reports.

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The heart is a vital muscular organ in vertebrate animals, responsible for maintaining blood circulation through rhythmic contraction. Although previous studies have investigated the heart proteome, the full hierarchical molecular network at cell-type and region resolved level, illustrating the specialized roles and crosstalk among different cell types and regions, remains unclear. Here, we presented an atlas of cell-type resolved proteome for mouse heart and region resolved proteome for both mouse and human hearts.

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Nanotechnology has become a groundbreaking innovation force in cancer therapy, offering innovative solutions to the limitations of conventional treatments such as chemotherapy and radiation. By manipulating materials at the nanoscale, researchers have developed nanocarriers capable of targeted drug delivery, improving therapeutic efficacy while reducing systemic toxicity. Nanoparticles like liposomes, dendrimers, and polymeric nanomaterials have shown significant promise in delivering chemotherapeutic agents directly to tumor sites, enhancing drug bioavailability and minimizing damage to healthy tissues.

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Background: An Andersson lesion (AL) is a late-stage lesion of ankylosing spondylitis (AS) that can be misdiagnosed. If the patient has unbearable pain or symptoms indicative of neurological damage, then posterior fusion can be considered. Compared with open surgical procedures, combining Unilateral biportal endoscopy (UBE) and 3D-printing technologies for endoscopic lumbar interbody fusion (LIF) can offer the advantages of minimal trauma and the same effect.

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Ampullary adenocarcinoma (AMPAC) is a rare and heterogeneous malignancy. Here we performed a comprehensive proteogenomic analysis of 198 samples from Chinese AMPAC patients and duodenum patients. Genomic data illustrate that 4q loss causes fatty acid accumulation and cell proliferation.

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This objective of this experiment was to compare and evaluate the performance, egg quality, and immune function of Tianfu green shell laying hens with varying feather growth rates, in order to provide a reference for their rational utilization. A total of 120 one-day-old healthy Tianfu green shell laying hens were classified into the early-feathering (EF) and late-feathering (LF) groups through phenotypic identification of feather length and qPCR molecular identification. Each group was subdivided into four replicates, with 30 chickens in each replicate.

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With global decarbonization urgency for sustainability, enhancing the service stability of liquid metals (LMs) and reducing their oxidation-induced failures are crucial. The oxidation of LMs can adversely affect the fluidity required for hydraulic transmission, thermal management, and other transport scenarios. Given the importance, we have fabricated an LM-based SiC/graphene-Mo nanofluid (LMNF) and compared the rheological behavior to pure LM under an oxidative atmospheric environment.

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Objective: To evaluate the clinical efficacy of large-channel endoscope-assisted posterior lumbar interbody fusion (Endo-PLIF), minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF), and open posterior lumbar interbody fusion in treatment of degenerative diseases of the lumbar spine.

Methods: Data of 110 patients with degenerative diseases of the lumbar spine were analyzed retrospectively: 31 patients underwent Endo-PLIF, 36 patients underwent MIS-TLIF, and 43 patients underwent modified TLIF. We compared operative duration, intraoperative blood loss, latent blood loss, intraoperative radiation dose, visual analog scale score, Oswestry Disability Index, anterior protrusion angle of the intervertebral space, postoperative ambulatory time, postoperative duration of hospital stay, and complications among the 3 groups.

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Multifunctional materials with outstanding performance have enormous potential applications in the next generation of nanodevices. Using first principles calculations, we design a series of multifunctional two-dimensional materials in monolayer αh-GeSe (, = 1, 2) that combine auxeticity and piezoelectricity. Due to the similar local structures of α-GeSe and h-GeSe, monolayer αh-GeSe can be designed through the combination of these two materials.

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CuInPS (CIPS) is an emerging 2D ferroelectric material known for disrupting spatial inversion symmetry due to Cu(I) position switching. Its ferroelectricity strongly relies on the Cu(I) atom/ion occupation ordering and dynamics. Nevertheless, the accurate Cu(I) occupations and correlated migration dynamics under the externally applied energy, which are key to unlocking ferroelectric properties, remain controversial and unresolved.

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Mass spectrometry (MS)-based proteomics has become instrumental in comprehensively investigating complex biological systems. Data-independent acquisition (DIA)-MS, utilizing hybrid spectral library search strategies, allows for the simultaneous quantification of thousands of proteins, showing promise in enhancing protein identification and quantification precision. However, low-quality profiles can considerably undermine quantitative precision, resulting in inaccurate protein quantification.

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JMJD1C, a member of the lysine demethylase 3 (KDM3) family, is universally required for the survival of several types of acute myeloid leukemia (AML) cells with different genetic mutations, representing a therapeutic opportunity with broad application. Yet how JMJD1C regulates the leukemic programs of various AML cells is largely unexplored. Here we show that JMJD1C interacts with the master hematopoietic transcription factor RUNX1, which thereby recruits JMJD1C to the genome to facilitate a RUNX1-driven transcriptional program that supports leukemic cell survival.

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Article Synopsis
  • Multi-omics studies have enhanced our understanding of breast ductal carcinoma (BRDC) biology and helped develop targeted therapies, but the sequence of key biological events during disease progression remains unclear.
  • A comprehensive analysis of 224 samples from 168 patients revealed that mutations in tumor protein P53 and overexpression of estrogen receptor 1 are critical for transitioning from ductal hyperplasia to ductal carcinoma in situ.
  • The study identifies specific molecular factors and pathways, including AKR1C1 as a potential therapeutic target, and highlights the effectiveness of aspirin and dydrogesterone against tumor cells, paving the way for treatment options throughout different stages of BRDC.
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Article Synopsis
  • Skull-base chordoma is a rare and aggressive bone cancer known for its high recurrence, and the study aims to understand its molecular characteristics and potential treatments through comprehensive analysis of 187 tumors.
  • The research identifies chromosome instability as a significant predictor of prognosis and a possible target for therapy, particularly highlighting RPRD1B in cases resistant to radiotherapy.
  • The study also characterizes tumor subtypes, revealing an immune cold subtype linked to poorer clinical outcomes, while showing that specific chromosomal gains and mitochondrial functions correlate with increased invasiveness in certain tumors.
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Background: Adjacent segment disease (ASD) after fusion surgery is frequently manifests as a cranial segment instability, disc herniation, spinal canal stenosis, spondylolisthesis or retrolisthesis. The risk factors and mechanisms of ASD have been widely discussed but never clearly defined.

Aim: To investigate the risk factors and clinical significance of retrograde movement of the proximal vertebral body after lower lumbar fusion.

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Understanding the input and output of data wrangling scripts is crucial for various tasks like debugging code and onboarding new data. However, existing research on script understanding primarily focuses on revealing the process of data transformations, lacking the ability to analyze the potential scope, i.e.

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Objective: This study aims to investigate the potential functions of miR-19a-3p in HCC.

Method: We collected serum samples to analyze miR-19a-3p expression. We utilized CCK8 and Transwell assays to access miR-19a-3p's influence on HCC cells malignancy.

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Article Synopsis
  • - The study investigates immune-mediated damage in the pancreas during COVID-19, revealing a buildup of harmful proinflammatory macrophages in human autopsy samples.
  • - Researchers employed advanced techniques, including single-cell RNA sequencing and human pluripotent stem cell-derived organoids, to study how these macrophages trigger β cell pyroptosis in response to SARS-CoV-2 and coxsackievirus B4.
  • - The findings identified a specific interaction (TNFSF12-TNFRSF12A) that mediates this damage, positioning the derived vascularized macrophage-islet organoids as crucial tools for further research on immune responses in viral infections.
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There is a paucity of human models to study immune-mediated host damage. Here, we utilized the GeoMx spatial multi-omics platform to analyze immune cell changes in COVID-19 pancreatic autopsy samples, revealing an accumulation of proinflammatory macrophages. Single cell RNA-seq analysis of human islets exposed to SARS-CoV-2 or Coxsackievirus B4 (CVB4) viruses identified activation of proinflammatory macrophages and β cell pyroptosis.

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Wilms' tumor is a malignant neoplasm where current medical advancements have significantly improved survival rates; however, challenges persist such as the resistance of the tumor to chemotherapy drugs like doxorubicin. This necessitates higher dosages, leading to decreased sensitivity. However, using high doses of doxorubicin can have late effects on the heart.

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This work aimed to develop and characterize a novel bi-layer film (BIF) for monitoring the freshness of salmon. The indicator layer consists of carrageenan (Car), pectin (PEC) and purple sweet potato anthocyanin (PSPA), and the antibacterial layer consists of Car and magnolol (Mag). The results showed that the Car/Mag2 had the optimal water resistance: the static water contact angle of 80.

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Background: : Hypertension is an important contributing factor to atherosclerotic cardiovascular disease (ASCVD), and multiple risk factors, many of which are implicated in metabolic disorders, contribute to the cause of hypertension. Despite the promise of multimodal data-driven prediction model, no such prediction model was available to predict the risk of ASCVD in Chinese individuals with new-onset hypertension and no history of ASCVD.

Methods: : A total of 514 patients were randomly allocated to training and verification cohorts (ratio, 7 : 3).

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While the world struggles to recover from the devastation wrought by the widespread spread of COVID-19, monkeypox virus has emerged as a new global pandemic threat. In this paper, a high precision and lightweight classification network MpoxNet based on ConvNext is proposed to meet the need of fast and safe detection of monkeypox classification. In this method, a two-branch depth-separable convolution residual Squeeze and Excitation module is designed.

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Objective: This study aims to assess the combined predictive value of C-reactive protein (CRP) and albumin (ALB) for major adverse cardiovascular events (MACE) post-percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI).

Methods: We analyzed data from continuously enrolled AMI patients who underwent emergency PCI at the First Affiliated Hospital of Xinjiang Medical University over six years, employing logistic regression to derive a predictive equation for in-hospital mortality and out-of-hospital MACE events. Primary endpoints: In-hospital death and out-of-hospital major adverse cardiovascular events.

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