Association between plasma CC16 levels and lung function changes in coke oven workers: A cohort study from 2014 to 2023.

Club cell secretory protein (CC16) is considered a biological marker indicating lung epithelial and lung permeability. The joint effect of polycyclic aromatic hydrocarbons (PAHs) exposure on CC16 levels and the association between CC16 levels and long-term lung function changes lacks epidemiological evidence. To investigate the effect of PAHs exposure on plasma CC16 levels and the association between CC16 levels and long-term lung function changes, this study enrolled 307 coke oven workers in 2014, measured their baseline concentrations of urinary PAHs metabolites and plasma CC16, with follow-up after nine years.

A prognostic model for interventional thrombectomy in patients with acute ischemic stroke based on a BP neural network, random forest model and decision tree model.

Objective: To investigate the predictive effect of a Back propagation (BP) neural network model, a random forest (RF) model and a decision tree model on the prognosis of interventional thrombolectomy for acute ischemic stroke (AIS) patients.

Methods: A total of 255 patients with AIS admitted to the Department of Neurology, Beiliu People's Hospital of Guangxi from March 2018 to February 2022 were retrospectively included, all of whom received interventional thromposectomy. Patients' prognosis was determined by the modified Rankin Scale (mRs) at 3 months after surgery, including the good prognosis group (mRs≤2 points) and the poor prognosis group (mRs 3-6 points).

Galectin-1 Regulates RNA Expression and Alternative Splicing of Angiogenic Genes in HUVECs.

Background: Angiogenesis is essential for tissue development, and therefore its dysregulation can cause various diseases, including cerebrovascular disease. Galectin-1, encoded by the lectin galactoside-binding soluble-1 gene (), has critical roles in the regulation of angiogenesis, but the underlying mechanisms need further clarification.

Methods: was silenced in human umbilical vein endothelial cells (HUVECs) and whole transcriptome sequencing (RNA-seq) was then performed to investigate potential targets for galectin-1.

Focusing on testosterone levels in male: A half-longitudinal study of polycyclic aromatic hydrocarbon exposure and diastolic blood pressure in coke oven workers.

Polycyclic aromatic hydrocarbons (PAHs) can interfere with testosterone levels, and low levels of testosterone are associated with increased cardiovascular events. To explore the role of testosterone in PAHs exposure and cardiovascular health, we used data from the 2011-2016 National Health and Nutrition Examination Survey (NHANES) and a longitudinal database of 332 male coke oven workers from China. The urine PAHs, tobacco metabolites and plasma testosterone levels of coke oven workers were measured.

Feasibility of automated in-vehicle technologies on volunteers' driving performance.

Background: Automated in-vehicle technologies, specifically in-vehicle information systems (IVIS) and advanced driver assistance systems (ADAS), are increasingly common in today's cars. Previous studies illustrate benefits of using IVIS and ADAS to improve safety, convenience, and comfort in healthy older drivers. However, research is sparse on the feasibility of such technologies for medically at-risk drivers, such as those with Parkinson's disease (PD).

Different observation period of exercise training in amyotrophic lateral sclerosis patients: A meta-analysis.

Objective: The purpose of this meta-analysis was to evaluate the effect of more intensive exercise training on the functional ability of patients with amyotrophic lateral sclerosis.

Methods: Randomized controlled trials on exercise training in amyotrophic lateral sclerosis patients were retrieved from PubMed, Embase, Web of Science, Cochrane Library and other databases, and meta-analysis was conducted using a fixed effect model or random effect model. Sensitivity analysis was used as a means to study heterogeneity.

Effect of Club cell secretory proteins on the association of tobacco smoke and PAH co-exposure with lung function decline: A longitudinal observation of Chinese coke oven workers.

Background: Exposure to polycyclic aromatic hydrocarbons (PAH) and tobacco smoke is associated with epithelial damage and reduced lung function. Club cell secretory protein (CC16) is a known biomarker for lung epithelial cells. However, the potential relationships between PAH and tobacco smoke exposure, CC16 levels, and reduced lung function remain unclear.

Facile preparation of FeO@Pt nanoparticles as peroxidase mimics for sensitive glucose detection by a paper-based colorimetric assay.

A simple strategy to rapidly detect glucose was developed by utilizing core (FeO)-shell (Pt) magnetic nanoparticles (FeO@Pt NPs) as a nanoenzyme and a paper-based colorimetric sensor. In the presence of HO, FeO@Pt NPs catalyze the redox reaction of 3,3',5,5'-tetramethylbenzidine (TMB) and generate a colour change from colourless to blue. On this basis, a colorimetric glucose sensing method assisted by glucose oxidase (GOx) was developed.

RCT protocol for driving performance in people with Parkinson's using autonomous in-vehicle technologies.

Introduction: Driving is an essential facilitator of independence, community participation, and quality of life. Drivers with Parkinson's Disease (PD) make more driving errors and fail on-road evaluations more than healthy controls. In-vehicle technologies may mitigate PD-related driving impairments and associated driving errors.

Severe Guillain-Barré syndrome associated with chronic hepatitis B: A case report and literature review.

Rationale: Guillain-Barré syndrome (GBS) is a postinfectious autoimmune peripheral neuropathy characterized by acute paralysis of the limbs. Clinically, extrahepatic manifestations of neurologic involvement in chronic hepatitis B (CHB) are uncommon. Little attention has been paid to the relationship between GBS and CHB viral infection.

Antibiofilm Effects of Epigallocatechin Gallate Against Wild-Type and Ampicillin-Induced Strains.

is an opportunistic pathogen associated with nosocomial infections and foodborne diseases. The resistance and biofilm formation of have been a great concern. In this study a multidrug-resistant strain 012 was exposed to a lethal dose of ampicillin (10 mg/mL, 2.

Ratiometric fluorescent probe for the on-site monitoring of coexisted Hg and F in sequence.

The monitoring of mercury and fluoride ions (Hg and F) has aroused wide concerns owing to the high toxicity of Hg and the duplicitous nature of F to human health. As far as we known, more than 100 million people in poverty-stricken areas are still at high risk of being over-exposed to Hg and F via drinking water. Simple and cost-effective luminescent methods are highly promising for on-site water monitoring in rural areas.

One-Step Microwave-Assisted Synthesis of PtNiCo/rGO Electrocatalysts with High Electrochemical Performance for Direct Methanol Fuel Cells.

Platinum (Pt) is widely used as an activator in direct methanol fuel cells (DMFCs). However, the development of Pt catalyst is hindered due to its high cost and CO poisoning. A multi-metallic catalyst is a promising catalyst for fuel cells.

Galectin-1-RNA interaction map reveals potential regulatory roles in angiogenesis.

Hyperactive angiogenesis contributes to the immunosuppressive microenvironment important for immunotherapy. Galectin-1, encoded by LGALS1, can trigger the vascular signaling programs and mediate the anti-angiogenic treatment response. However, the mechanism through which galectin-1 regulates angiogenesis is poorly understood.

Clinical characteristics of a group of deaths with COVID-19 pneumonia in Wuhan, China: a retrospective case series.

Background: With the widespread outbreak of novel coronavirus diseases 2019(COVID-19), more and more death cases were reported, however, limited data are available for the patients who died. We aimed to explore the clinical characteristics of deaths with COVID-19 pneumonia.

Methods: We abstracted and analyzed epidemiological, demographic, clinical, and laboratory data from 83 death cases with COVID-19 pneumonia in East Hospital of Wuhan University Renmin Hospital, between January 26, 2020, and February 28, 2020.

Isolation of Trametes hirsuta La-7 with high laccase-productivity and its application in metabolism of 17β-estradiol.

Estrogens, which are extensive in the eco-environments, are a category of high-toxic emerging contaminants that induce metabolic disorders and even carcinogenic risks in wildlife and humans. Here we investigate whether fungus-secreted laccase can be used as a green catalyst to eliminate a representative estrogen, 17β-estradiol (E2). A white-rot fungus Trametes hirsuta La-7 with high laccase-productivity, was isolated from pig manure-contaminated soil.

Low-Temperature Solution-Processed Zinc Tin Oxide Film as a Cathode Interlayer for Organic Solar Cells.

In this study, Sn-doped ZnO (ZTO) is prepared by a sol-gel method and is employed as an electron transport material for organic solar cells (OSCs). After Sn modification, the fabricated ZTO films exhibited better charge transport properties and smoother surface morphology, especially for those processed at a low temperature of 120 °C. By incorporation of the high-temperature (200 °C) processed ZTO films, inverted OSCs showed the highest power conversion efficiency (PCE) of 9.

Interfacial Materials for Organic Solar Cells: Recent Advances and Perspectives.

Organic solar cells (OSCs) have shown great promise as low-cost photovoltaic devices for solar energy conversion over the past decade. Interfacial engineering provides a powerful strategy to enhance efficiency and stability of OSCs. With the rapid advances of interface layer materials and active layer materials, power conversion efficiencies (PCEs) of both single-junction and tandem OSCs have exceeded a landmark value of 10%.

Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway.

For the aging populations of any nation, Dementia is becoming a primary problem and Alzheimer’s dementia (AD) is the most common type. However, until now, there is no effective treatment for AD. Tanshinone IIA (Tan IIA) has been reported for neuroprotective potential to against amyloid β peptides (Aβ)-induced cytotoxicity in the rat pheochromocytoma cell line PC-12, which is widely used as AD research model, but the mechanism still remains unclear.

The neuroprotective effects of cyclin-dependent kinase-5 inhibition in mice with Niemann-Pick disease type C.

In order to investigate the neuroprotective effects of cyclin-dependent kinase-5 (cdk-5) inhibition in mice with Niemann-Pick disease type C (NPC) (npc(-/-)), recombinant adeno-associated virus (rAAV) carrying the small interfering RNA (siRNA) specific for cdk-5 gene was injected into 3-day-old npc(-/-) mice intracerebroventricularly. The rAAV-GFP-injected age-matched npc(-/-) mice and non-surgery age-matched npc(-/-) mice were employed as controls (n=6-10/group). From the 4th to 8th week after the treatment, mice were weighed, and evaluated for limb motor activity by using the coat hanger test once a week.

Packaging and functional identification of recombinant adeno-associated virus encoding cdc2-siRNA.

Cyclin dependent kinases (cdks) play an important role in the pathogenesis of multiple neurodegenerative diseases. To explore the possibility of cdks-related gene therapy for neurodegenerative diseases, we packed recombinant adeno-associated virus (rAAV) encoding cdc2-siRNA. The expressing plasmid pAAV-MCS-EGFP-U6-cdc2-siRNA was constructed by using molecular biological techniques.