Transcriptomics and Metabolomics Explain the Crisping Mechanisms of Broad Bean-Based Crisping Diets on Nile Tilapia ().

To investigate the crisping mechanism of broad bean-based crisping diets on Nile Tilapia. Four crisping diets were designed to feed 360 fish for 90 days, and multiomics analyses were employed. Our results indicated that the designed crisping diets for Nile tilapia can effectively make tilapia muscle crispy.

Elucidating of the metabolic impact of risperidone on brain microvascular endothelial cells using untargeted metabolomics-based LC-MS.

Risperidone is useful for the treatment of schizophrenia symptoms; however, it also has side effects, and an overdose can be harmful. The metabolic effects of risperidone at high therapeutic doses and its metabolites have not been elucidated. Endogenous cellular metabolites may be comprehensively analyzed using untargeted metabolomics-based liquid chromatography-mass spectrometry (LC-MS), which can reveal changes in cell regulation and metabolic pathways.

Study of the magnetism of C-doped MgO based on first-principles calculations and the Ising model.

The electronic and magnetic properties of d dilute magnetic semiconductors formed by rock-salt structured magnesium oxide (MgO) doped with C are systematically studied based on first-principles calculations and the Ising model. It is shown that the electronic holes of p states are generated due to the impurity carbon replacing oxygen in MgO, and the magnetic moment of 2 is introduced by each C impurity. The polarization energy and formation energy of C-doped MgO are calculated, and the magnetization energy of C-doped MgO is also calculated which is used to obtain the exchange constant between C impurities.

Effects of Broad Bean Diet on the Growth Performance, Muscle Characteristics, Antioxidant Capacity, and Intestinal Health of Nile Tilapia ().

Four crisping diets were designed to conduct a feeding experiment to investigate the use of broad bean in the formulated feed of Nile tilapia and optimize its use. The growth performance, muscle characteristics, antioxidant capacity, and intestinal health of Nile tilapia with an initial body weight of 617.32 ± 1.

Metabolomic identification of biochemical changes induced by fluoxetine in an insulinoma cell line (MIN6).

Background And Purpose: The use of fluoxetine raises the risk of pancreatic beta-cell dysfunction. However, the specific mechanism behind its mechanism of action in beta cells is unknown. This study investigated the cellular response of MIN6 cells to fluoxetine using untargeted cell-based metabolomics.

Exploring the mechanisms of clozapine-induced blood-brain barrier dysfunction using untargeted metabolomics and cellular metabolism analysis.

Brain microvascular endothelial cells (BMVECs) from the blood- brain barrier form a highly selective membrane that protects the brain from circulating blood and maintains a stable microenvironment for the central nervous system. BMVEC dysfunction has been implicated in a variety of neurological and psychiatric disorders. Clozapine, a widely used antipsychotics, has been demonstrated to alter the permeability of BMVECs, but the underlying mechanisms of this effect are not fully understood.

Synthesis of Chiral 1,1,1-Trifluoro--disubstituted 2,4-Diketones via Palladium-Catalyzed Asymmetric Allylation.

Trifluoromethyl ketones are important enzyme inhibitors and versatile synthons for the preparation of trifluoromethylated heterocycles and complex molecules. An efficient methodology for the synthesis of chiral 1,1,1-trifluoro-α,α-disubstituted 2,4-diketones via palladium-catalyzed allylation with allyl methyl carbonates under mild conditions has been developed. This method surmounts the major obstacle of detrifluoroacetylation, and a chiral trifluoromethyl ketone library could be rapidly built up from simple substrates in good yields and enantioselectivities, thereby offering a new choice for scientists in pharmaceutical and material industries.

Parental Discipline Techniques and Changes in Observed Temper Tantrum Severity in Toddlers.

Although temper tantrums are considered a normal part of emotional development in toddlerhood, for some they foreshadow more serious behavioral and emotional problems. Parental discipline techniques may play a role in explaining why this behavior worsens for some children whereas for others it fades away. With this three-wave longitudinal study, we examined bidirectional associations between specific discipline techniques - ignoring, power assertion, and consistency - and intra-individual changes in the severity of tantrum behavior.