Enzymatic nanomotors with chemotaxis for product-based cancer therapy.

The development of an intelligent nanomotor system holds great promise for enhancing the efficiency and effectiveness of antitumor therapy. Leveraging the overexpressed substances in the tumor microenvironment as propellants and chemotactic factors for enzyme-powered nanomotors represents a versatile and compelling approach. Herein, a plasma amine oxidase (PAO)-based chemotactic nanomotor system has been successfully developed, with the ability to enzymatically produce toxic acrolein and HO from the upregulated polyamines (PAs) in the tumor microenvironment for active tumor therapy.

Magnetically Powered Microrobotic Swarm for Integrated Mechanical/Photothermal/Photodynamic Thrombolysis.

Current thrombolytic drugs exhibit suboptimal therapeutic outcomes and potential bleeding risks due to their limited circulation time, inadequate thrombus penetration, and off-target biodistribution. Herein, a photosensitizer-loaded, red cell membrane-encapsuled multiple magnetic nanoparticles aggregate is successfully developed for integrated mechanical/photothermal/photodynamic thrombolysis. Red cell membrane coating endows magnetic particles with prolonged blood circulation and superior biocompatibility.

Distinguishing preeclampsia using the falling scaled slope (FSS) --- a novel photoplethysmographic morphological parameter.

Background: Preeclampsia (PE) presence could lead to hemodynamic changes. Previous research suggested that morphological parameters based on photoplethysmographic pulse waves (PPGW) could help diagnose PE.

Aim: To investigate the performance of a novel PPGPW-based parameter, falling scaled slope (FSS), in distinguishing PE.

Self-regulated immobilization behavior of multiple heavy metals via zeolitization towards a novel hydrothermal technology for soil remediation.

More efficient soil remediation technologies are highly anticipated to treat large quantities of heavy metal-polluted urban sites nowadays. Herein, a novel hydrothermal technology of converting heavy metal-polluted soils into zeolites for in-situ immobilizing heavy metals was proposed. The zeolites (analcime and cancrinite) could be synthesized hydrothermally with certain Na/Si and Al/Si ratios.

Effect of Laryngeal Mask Airway Insertion on Parameters Derived From Catacrotic Phase of Photoplethysmography Under Different Concentrations of Remifentanil.

Background: Some parameters have been extracted from photoplethysmography (PPG) with a good relativity with nociception, but without encouraging results in qualifying the balance of nociception-anti-nociception (NAN). The features of PPG have not been thoroughly depicted and more prospective univariate parameters deserve to be explored. The aim of this study was to investigate the ability of parameters derived from catacrotic phase of PPG to grade the level of analgesia.

Comparison of Three Normalization Methods in Monitoring Analgesic Depth with Photoplethysmographic Diastolic Interval.

The purpose of the present study was to investigate the ability of three different normalization methods, namely root mean square (RMS) value, mean value, and maximum which referred to pulse beat interval (PBI), based on photoplethysmographic diastolic interval (DI) in response to laryngeal mask airway (LMA) insertion under various remifentanil concentrations during general anesthesia. Sixty patients were randomly allocated to one of the four groups to receive a possible remifentanil effect-compartment target concentration (Ce) of 0, 1, 3, or 5 ng/ml, and an effect-compartment target controlled infusion of propofol to maintain the state entropy (SE) at 40~60. Three normalized measures DI, DI, and DIPBI were compared with the DI values without normalization.

[Emotion Recognition Based on Multiple Physiological Signals].

Emotion is a series of reactions triggered by a specific object or situation that affects a person's physiological state and can, therefore, be identified by physiological signals. This paper proposes an emotion recognition model. Extracted the features of physiological signals such as photoplethysmography, galvanic skin response, respiration amplitude, and skin temperature.

Photoplethysmography-derived approximate entropy and sample entropy as measures of analgesia depth during propofol-remifentanil anesthesia.

The ability to monitor the physiological effect of the analgesic agent is of interest in clinical practice. Nonstationary changes would appear in photoplethysmography (PPG) during the analgesics-driven transition to analgesia. The present work studied the properties of nonlinear methods including approximate entropy (ApEn) and sample entropy (SampEn) derived from PPG responding to a nociceptive stimulus under various opioid concentrations.

Photoplethysmography Response to Laryngeal Mask Airway Insertion during Propofol-Remifentanil Anethesia.

The present study was aimed to evaluate the abilities of photoplethysmography (PPG)-derived parameters, including sample entropy of PPG (SampEn), amplitude of PPG (PPGA), pulse beat interval (PBI) and diastolic interval (DI) extracted by nonlinear or linear methods, to monitor the balance between nociception and antinociception. 26 ASA I or II patients were randomized into one of the three groups to receive a remifentanil effect-compartment target controlled infusion (Ce) of 1, 3 and 5 ng/ml and an effect-compartment target controlled propofol infusion (Ce) to keep the state entropy (SE) at 50 (40~60). Laryngeal mask airway (LMA) insertion was applied as a noxious stimulus.

An injectable thermosensitive hydrogel loaded with an ancient natural drug colchicine for myocardial repair after infarction.

Localized administration of anti-inflammatory agents benefits patients after myocardial infarction (MI) by repressing/modulating inflammatory response of the MI region and thus accelerating repair of the impaired tissues. Colchicine (Col), an ancient natural drug, has excellent anti-inflammatory effects; however, its utilization is strictly limited due to its severe systemic toxicity and narrow therapeutic window. In this study, we developed an intramyocardial delivery system of Col using an injectable, thermosensitive poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) (PLGA-PEG-PLGA) polymer hydrogel as the vehicle for the treatment of MI while minimizing its systemic toxicity.

A novel parameter derived from photoplethysmographic pulse wave to distinguish preeclampsia from non-preeclampsia.

Objective: To describe the comparative hierarchical area ratio (CHAR), a novel parameter derived from the photoplethysmographic (PPG) pulse wave and differences in CHAR values in parturients with and without preeclampsia (PE).

Methods: A total of 59 parturients (37 without and 22 with PE) was conducted at the Women's Hospital, Zhejiang University, School of Medicine in Hangzhou, China. We calculated the CHAR values derived from the PPG pulse wave and compared them in parturients with and without PE.

A novel hydrothermal method to convert incineration ash into pollucite for the immobilization of a simulant radioactive cesium.

The Fukushima nuclear accident in Japan on March 11, 2011 produced huge amounts of Cs-polluted incineration ashes; conventional solidification methods seem unsuitable for the treatment of large amounts of Cs-polluted ashes. A novel hydrothermal method was developed to directly convert Cs-polluted incineration ash (rice husk ash) into pollucite to immobilize Cs in its crystal structure in situ. Results revealed that pollucite could be synthesized readily over a wide range of added Cs (Cs/Si=0.