Publications by authors named "Jiajun Fan"

Phytophthora nicotianae is a highly destructive soil-borne plant pathogen that leads to significant economic losses in agriculture. Chitooligosaccharides (COS) are popular biostimulant which can promote plant growth and responses to biotic and abiotic stresses. However, the role of COS in resisting the black-shank disease (BSD, caused by P.

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Pressure garment therapy is a common strategy for controlling hypertrophic scars; however, insufficient pressure due to reduced elasticity or joint movement limits its effectiveness around joints. The FlexiForce B201 pressure sensor offers precise pressure measurements, thereby demonstrating a promising solution. This study used a Bama pig scar model with an untreated group, a pressure garment group, and a pressure monitoring group that was treated with FlexiForce B201 sensors and pressure garments.

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Coal mining has resulted in pollution of groundwater in mining areas, which poses a risk to human health. However, understanding of groundwater evolution in mining areas and the associated implications remains insufficient. This study collected 13 groundwater samples from an abandoned coal mine in southwestern China.

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Immune checkpoint inhibitors (ICIs) have significantly advanced the field of cancer immunotherapy. However, clinical data has shown that many patients have a low response rate or even resistance to immune checkpoint inhibitor alone. The underlying reasons for its poor efficacy include the deficiency of immune infiltration and effective CD28/CD80 costimulatory signal in tumor.

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Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic liver disorder worldwide, and effective therapeutic strategies for its treatment remains limited. In this article, we introduced Glipo-siRubi, a hepatocytes-targeting RNA interference (RNAi) nanoliposome for suppression of Rubicon expression, aiming to achieve precise regulation of autophagy in NAFLD. Autophagy activation induced by Rubicon suppression resulted in reduced endoplasmic reticulum stress and intracellular lipid accumulation in vitro.

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Acute myeloid leukemia (AML) is a severe blood cancer with an urgent need for novel therapies for refractory or relapsed patients. Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), an immune suppressive receptor expressed on immune cells and AML blasts but minimally on hematopoietic stem cells (HSCs), represents a potential therapeutic target. But there has been limited research on therapies targeting LAIR1 for AML and no published reports on LAIR1 antibody-drug conjugate (ADC).

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In this study, a frustum-shaped addition was made to a cylindrical absorber unit, utilizing 1-ethyl-3-methylimidazolium dicyanamide ionic liquid (IL) to create a transparent all-dielectric liquid metamaterial absorber (A-D ILMMA). The A-D ILMMA achieved over 90% absorption efficiency across 4.86-50.

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Atherosclerosis (AS) ultimately cause major adverse cardiovascular events (MACEs). While traditional strategies by lipid-reducing have reduced MACEs, many patients continue to face significant risks. It might attribute to the upregulation of CD47 expression in AS lesions, that mediated anti-efferocytosis of macrophages.

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Article Synopsis
  • Researchers are focusing on developing new materials to effectively adsorb heavy metals for environmental cleanup, specifically using a novel composite called covalent organic framework-modified biochar (RH-COF).
  • The study shows that modifying biochar with COF significantly increases its nitrogen and oxygen content, which boosts its ability to adsorb cadmium (Cd) from 4.20 mg/g to 58.62 mg/g, a fourteen-fold enhancement.
  • The adsorption process for Cd on RH-COF follows specific models, is largely unaffected by pH within a certain range, and involves various mechanisms like surface complexation, electrostatic interactions, and more, indicating its potential for environmental remediation.
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Lignin valorisation into chemicals and fuels is of great importance in addressing energy challenges and advancing biorefining in a sustainable manner. In this study, on the basis of the high microwave absorption performance of carbon nanotubes (CNTs), a series of copper-oxide-loaded CNT catalysts (CuO/CNT) were developed to facilitate the oxidative depolymerization of lignin under microwave heating. This catalyst can promote the activation of hydrogen peroxide and air, effectively generating a range of reactive oxygen species (ROS).

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Er-doped glasses and fibers with broadband near infrared (NIR) emission have been widely applied in EDFA. Limited by optical gain band of Er-doped glasses and fibers, it was hardly meet to the demands of broadband amplification in the C + L band. In this work, six glass matrixes were employed for discussing the influence of glass matrix on the Stark splitting of Er and the wavelength of laser output and amplification.

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Article Synopsis
  • The study investigates how the microbiota influences gene expression and physiological functions in mice, focusing on mRNA landscapes in brain and cecum tissues.
  • Using nanopore direct RNA sequencing, it reveals that the microbiome affects RNA modifications, isoform generation, and transcript abundance, demonstrating significant control over post-transcriptional processes.
  • The findings highlight a tissue-specific impact of the microbiome on host gene expression regulation, advancing understanding of microbial contributions to gene expression mechanisms.
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Objective: Blood lipid levels play a critical role in the progression of atherosclerosis. However, even with adequate lipid reduction, significant residual cardiovascular risk remains. Therefore, it is necessary to seek novel therapeutic strategies for atherosclerosis that can not only lower lipid levels but also inhibit inflammation simultaneously.

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Background: The main challenge against patients with cancer to derive benefits from immune checkpoint inhibitors targeting PD-1/PD-L1 appears to be the immunosuppressive tumor microenvironment (TME), in which IL-33/ST2 signal fulfills critical functions. However, whether IL-33 limits the therapeutic efficacy of anti-PD-L1 remains uncertain.

Methods: Molecular mechanisms of IL-33/ST2 signal on anti-PD-L1 treatment lewis lung carcinoma tumor model were assessed by RNA-seq, ELISA, WB and immunofluorescence (IF).

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Solution-processed silver nanowire (AgNW) networks have been considered as promising electrode candidates for next-generation electronic devices. However, they suffer from poor thermal and electrical stability and low mechanical properties, hindering their practical applications. In this work, graphene nanosheets are successfully introduced into AgNW via a facile one-step solvothermal process.

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Non-alcoholic fatty liver disease (NAFLD) is a prominent cause of various chronic metabolic hepatic diseases with limited therapeutics. Rubicon, an essential regulator in lysosomal degradation, is reported to exacerbate hepatic steatosis in NAFLD mice and patients, indicating its probability of being a therapeutic target for NAFLD treatment. In this study, the therapeutic potential of Rubicon blockage is investigated.

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Acute liver failure (ALF) is a serious inflammatory disorder with high mortality rates, which poses a significant threat to human health. The IL-33/ST2 signal is a crucial regulator in inflammation responses associated with lipopolysaccharide (LPS)-induced macrophages. The IL-17A signaling pathway promotes the release of chemokines and inflammatory cytokines, recruiting neutrophils and T cells under LPS stimulation, thus facilitating inflammatory responses.

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Article Synopsis
  • Gut microbiota affects host gene expression and physiology through metabolites, particularly influencing the transcriptome and mA epitranscriptome.
  • Research using mouse models reveals that antibiotics can disrupt gut microbiota, leading to significant changes in bile acid metabolism and its related microbiota.
  • The study highlights a link between bile acid metabolism and mA writer protein expression, illustrating how dysbiosis can reshape host gene expression and epitranscriptomic landscapes.
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Article Synopsis
  • - The study examines how the COVID-19 pandemic has affected the mental health of college students, highlighting the need for universities to adopt measures to alleviate these effects.
  • - A survey of 1,445 college students revealed key factors contributing to mental health challenges, including academic stress from COVID-related research and varying mental health statuses based on information-sharing habits.
  • - The findings suggest that playing games can be an effective coping strategy, and the research advocates for institutions to implement proactive and diverse approaches to support student mental health.
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Research and development on Nectin-4 antibody-drug conjugates (ADC) have been greatly accelerated since the approval of enfortumab vedotin to treat uroepithelial cancer. During the course of this study, we identified that autophagy serves as a cytoprotective mechanism during Nectin-4-MMAE treatment and proposed a strategy to enhance the antitumor effects of Nectin-4-MMAE in bladder cancer. Nectin-4-MMAE rapidly internalized into bladder cancer cells in 30 minutes and released MMAE, inducing the onset of caspase-mediated apoptosis and leading to the inhibition of tumor cell growth.

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The activation of T lymphocytes is a crucial component of the immune response, and the presence of CD80, a membrane antigen, is necessary for T-cell activation. CD80 is usually expressed on antigen-presenting cells (APCs), which can interact with cluster of differentiation 28 (CD28) or programmed cell death ligand 1 (PD-L1) to promote T-cell proliferation, differentiation and function by activating costimulatory signal or blocking inhibitory signal. Simultaneously, CD80 on the APCs also interacts with cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) on the surface of T cells to suppress the response of specific effector T cells, particularly in the context of persistent antigenic stimulation.

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Microwave hydrothermal (MHT) conversion is emerging as a promising technology for the disposal and reutilization of biowastes. This study investigated the fundamental properties and phosphorus transformation mechanism of soybean straw during the MHT conversion process. The oxygen-containing functional groups in soybean straw were stripped, and a trend of dehydration was observed as the temperature increased during the MHT process.

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Introduction: Several studies have examined the risk factors for post-percutaneous kyphoplasty (PKP) refractures and developed many clinical prognostic models. However, no prior research exists using the Random Forest (RF) model, a favored tool for model development, to predict the occurrence of new vertebral compression fractures (NVCFs). Therefore, this study aimed to investigate the risk factors for the occurrence of post-PKP fractures, compare the predictive performance of logistic regression and RF models in forecasting post-PKP fractures, and visualize the logistic regression model.

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Macrophages are the origin of most foam cells in the early stage of atherosclerotic plaques. However, the mechanism involved in the formation of macrophage-derived foam cell formation remains unclear. Here, we revealed that the hedgehog (Hh) signaling is critical in autophagy-lysosome pathway regulation and macrophage-derived foam cell formation.

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