Publications by authors named "Jiaju Yang"
Objective: Knee osteoarthritis (KOA) is characterized by structural changes. Aging is a major risk factor for KOA. Therefore, the objective of this study was to examine the role of genes related to aging and circadian rhythms in KOA.
View Article and Find Full Text PDFObjective: This meta-analysis evaluates the comparative efficacy of lateral unicompartmental arthroplasty (UKA) versus medial UKA in treating unicompartmental knee osteoarthritis (KOA).
Methods: We systematically searched Cochrane, PubMed, Embase, and Web of Science databases from January 2000 to September 2024. Literature screening, quality assessment, and data extraction were conducted based on predefined inclusion and exclusion criteria.
Background: Patellofemoral joint (PFJ) diseases are chronic degenerative conditions that contribute to knee joint symptoms. Unicompartmental knee arthroplasty (UKA) is widely regarded as an effective treatment for knee osteoarthritis (KOA); however, its specific indications remain a subject of debate.
Hypothesis: Patients with PFJ disease are expected to experience outcomes post-UKA comparable to those of patients without PFJ disease.
Article Synopsis
- The study investigates the link between spontaneous osteonecrosis of the knee (SONK) and associated meniscus tears, aiming to clarify their relationship and underlying causes.
- Researchers analyzed eight English articles, encompassing 405 patients to calculate the odds ratios and confidence intervals for meniscus lesions in relation to SONK.
- Findings reveal a significant association between SONK and the prevalence of meniscus and root tears, suggesting that SONK might be better defined as subchondral insufficiency fracture of the knee.
Article Synopsis
- A meta-analysis was conducted to compare the effectiveness of Oxford unicompartmental knee arthroplasty (OUKA) for treating spontaneous osteonecrosis of the knee (SONK) and medial knee osteoarthritis (MKOA).
- The analysis included 9 studies with 1544 total knees, where the results indicated no significant differences in various postoperative outcomes between SONK and MKOA groups, such as knee function scores, mobility, and pain.
- The study concluded that OUKA treatment for both conditions yields similar satisfaction levels among patients.
Background: Traumatic brain injury (TBI) is one of the most serious types of trauma and imposes a heavy social and economic burden on healthcare systems worldwide. The development of emerging biotechnologies is uncovering the relationship between TBI and gut flora, and gut flora as a potential intervention target is of increasing interest to researchers. Nevertheless, there is a paucity of research employing bibliometric methodologies to scrutinize the interrelation between these two.
View Article and Find Full Text PDFUnicompartmental knee arthroplasty (UKA) is an established treatment option for anteromedial osteoarthritis, and popliteal cysts are a common finding in the knee among patients with chronic osteoarthritis pain. The two are so closely related that popliteal cysts are commonly discovered during the unicompartmental knee arthroplasty preoperative examination. However, only a few reports exist on the management and outcome of popliteal cysts in the patients receiving UKA for knee osteoarthritis (OA) and popliteal cysts.
View Article and Find Full Text PDFFree fatty acid 1 (FFA1/GPR40) has attracted extensive attention as a novel target for the treatment of type 2 diabetes for its role in the enhancement of insulin secretion with glucose dependency. Aiming to develop novel potent FFA1 agonists, a new series of phenylpropionic acid derivatives were designed and synthesized on the basis of the modification of chemical cement of TAK-875, AMG-837, and LY2881835. Among them, most promising compounds 7, 14, and 15 were obtained with EC values of 82, 79, and 88 nM, exhibiting a powerful agonistic activity compared to TAK-875 (95.
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