Publications by authors named "Jiajie Zhao"
Article Synopsis
- Mitochondrial dysfunction and oxidative stress are crucial factors in diabetic retinal damage, and the study investigates the antioxidant Honokiol (HKL) for its potential protective effects against diabetic retinopathy (DR).
- Using a type 2 diabetic mouse model, HKL was found to reduce retinal vascular leakage and capillary cell apoptosis, enhancing cell viability and decreasing oxidative stress when exposed to high glucose levels.
- The protective effects of HKL were linked to the activation of sirtuin 3 (SIRT3), suggesting that HKL improves mitochondrial function and offers a potential new treatment approach for DR.
Aging is a challenge to global development. This challenge is particularly significant for China because it has the largest elderly population worldwide. The proportion of aging population continues to increase, and solely relying on government efforts to meet the needs of the elderly is inadequate.
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