Optimizing surface active sites via burying single atom into subsurface lattice for boosted methanol electrooxidation.

The precise fabrication and regulation of the stable catalysts with desired performance still challengeable for single atom catalysts. Here, the Ru single atoms with different coordination environment in NiFeN lattice are synthesized and studied as a typical case over alkaline methanol electrooxidation. The NiFeN with buried Ru atoms in subsurface lattice (NiFeN-Ru) exhibits high selectivity and Faradaic efficiency of methanol to formate conversion.

Asymmetric synthesis of atropisomers featuring cyclobutane boronic esters facilitated by ring-strained B-ate complexes.

The strain-release-driven reactions of bicyclo[1.1.0]butanes (BCBs) have received significant attention from chemists.

Evaluating spatial effect of transportation planning factors on taxi CO emissions.

In recent years, the impact of transportation activities on carbon (CO) emissions has gained global attention. In China, the severity of CO emissions from transportation is a pressing issue, necessitating the development of effective emission reduction strategies. This study uses taxi GPS data from Xi'an, China, to explore the spatial patterns and influencing factors of CO2 emissions.

Enhancer Enh483 regulates myoblast proliferation and differentiation of buffalo myoblasts by targeting FAXC.

A detailed understanding of the precise regulatory mechanisms governing buffalo skeletal muscle is crucial for improving meat quality and yield. Proper skeletal muscle fate decisions necessitate the accurate regulation of key enhancers. This study screened nine potential enhancers linked to muscle development by analysing ATAC-seq data from buffalo myoblasts during the proliferative and differentiative phases.

Efficacy, safety, and somatosensory comparison of pulsed-field ablation and thermal ablation: outcomes from a 2-year follow-up.

Background: Pulsed-field ablation (PFA), as a nonthermal ablative approach for atrial fibrillation, has attracted much attention in recent years. And there are few comparative studies on PFA versus conventional thermal ablation, including radiofrequency ablation (RFA) and cryoballoon ablation (CBA). The efficacy, safety, and somatic sensation of PFA and thermal ablation need to be further compared.

PTPN22 and the pathogenesis of ulcerative colitis: Insights into T cell differentiation and the JAK/STAT signaling pathway.

70 % of the ulcerative colitis (UC) linked gene loci are associated with other autoimmune or immunodeficient diseases. The phosphatase activity of PTPN22 can regulate the development of T cells and contribute to regulate the level of inflammation in autoimmune diseases. We produced PTPN22-CS thymus-specific transgenic mice, which suppressed PTPN22 enzyme activity in the thymocytes.

The role of telomere shortening in ambient ozone exposure-related insulin resistance.

Background: Ozone (O) exposure and telomere shortening are associated with insulin resistance (IR). However, the role of telomere shortening in ambient O exposure-related IR is largely unclear.

Methods: The Henan Rural Cohort recruited participants and performed a random forest method to estimate residential O concentration.

Instant oxidase- and peroxidase-mimic activities of in-situ reductive coordinated Cu(I)-polytrithiocyanuric acid for HS colorimetric detection and antibacterial.

Integrating preparation and utilization of nanozymes in a "one-pot" approach offers advantages over conventional discrete synthesis and application methods by eliminating laborious syntheses, reducing energy consumption, and minimizing chemical waste. Herein, we revealed the instant oxidase- and peroxidase-mimic (OD-/POD-mimic) activities of in-situ formed Cu(I)-polytrithiocyanuric acid (i:Cu(I)-pTTCA) polymers. The polymers were assembled through reductive coordination between Cu and trithiocyanuric acid and immediately exhibited intrinsic OD- or POD-mimic activities.

Near-Infrared-II-Activated Transition Metal(II)-Coordinated Ligand Radical Primes Robust Anticancer Immunity.

Photoactivatable metallodrugs combining tumor cell eradication and immune stimulation hold immense promise for targeted cancer therapy. However, limitations such as oxygen dependence, narrow visible light responsiveness, and poor immunogenicity hinder their efficacy in deep solid tumors with hypoxic and immunosuppressive microenvironments. Herein, we present a novel design strategy for transition metal(II)-coordinated ligand radicals exhibiting intense near-infrared-II (NIR-II) absorption, unique endoplasmic reticulum-targeting capability, and oxygen-independent photothermal performance, effectively addressing these constraints.

Biomimetic Microstructure with Anti-Slip and Anti-Adhesion for Efficient Handling of Brittle Material Surfaces in High-Temperature Environments.

Non-destructive handling such as wafer handling usually requires a high-temperature environment, however, most bionic materials fail in high temperatures due to material decomposition. In this study, inspired by the unique microstructure of locust toe pads with low adhesion and high friction, bionic high-temperature friction pads are designed and fabricated, selecting high-temperature-resistant silicone rubber as the material. The interfacial mechanical properties at high temperatures are analyzed.

Epigenetic modifications involving ncRNAs in digestive system cancers: focus on histone modification.

In recent years, epigenetic modifications have been strongly linked to tumor development, with histone modifications representing a key epigenetic mechanism. In addition, non-coding RNAs (ncRNAs) play a critical role in regulating cancer-related pathways. The abnormal interaction between histone modifications and ncRNAs, both pivotal epigenetic regulators, has been widely observed across various cancer types.

A Case Study on Assessing AI Assistant Competence in Narrative Interviews.

Background: Researchers are leading the development of AI designed to conduct interviews. These developments imply that AI's role is expanding from mere data analysis to becoming a tool for social researchers to interact with and comprehend their subjects. Yet, academic discussions have not addressed the potential impacts of AI on narrative interviews.

Serine Hydroxymethyltransferase 2 Deficiency in the Hematopoietic System Disrupts Erythropoiesis and Induces Anemia in Murine Models.

Serine and folate metabolism play critical roles in erythroid development in both embryonic and adult mice; however, the precise roles of these metabolic pathways in erythropoiesis and the pathophysiology of anemia remain inadequately characterized in the literature. To delineate the contributions of serine and folate metabolism to erythroid differentiation, we focused on serine hydroxymethyltransferase 2 (SHMT2), a key regulatory enzyme within these metabolic pathways. Using gene-editing techniques, we created fetal and adult mouse models with targeted deletion of in the hematopoietic system.

The role of PAR2 in regulating MIF release in house dust mite-induced atopic dermatitis.

Atopic dermatitis (AD) is a chronic disease characterized by relapsed eczema and intractable itch, and is often triggered by house dust mites (HDM). PAR2 is a G-protein coupled receptor on keratinocytes and may be activated by HDM to affect AD processes. We first established a HDM-derived AD mouse model in wild-type (WT) and mice.

Benzo(a)anthracene Targeting SLC1A5 to Synergistically Enhance PAH Mixture Toxicity.

Human exposure to polycyclic aromatic hydrocarbons (PAHs) as mutagenic and carcinogenic pollutants in the environment often occurs in the form of mixtures. Although the mixture effects of PAHs have been previously recognized, the toxicological mechanisms to explain them still remain quite unclear. This study combined metabolomics and chemical proteomics methods to comprehensively understand the mixture effects of a PAH mixture including benzo(a)anthracene (BaA), benzo(b)fluoranthene (BbF), benzo(a)pyrene (BaP), and chrysene (CHR).

Association between high-density lipoprotein-related inflammation index and periodontitis: insights from NHANES 2009-2014.

Background: Periodontitis, a persistent inflammatory condition, significantly impairs individuals' overall quality of life. Lymphocyte-to-high-density lipoprotein cholesterol ratio (LHR), monocyte-to-high-density lipoprotein cholesterol ratio (MHR), neutrophil-to-high-density lipoprotein cholesterol ratio (NHR), and platelet-to-high-density lipoprotein cholesterol ratio (PHR) are new convenient and economical biomarkers. However, whether the above high-density lipoprotein-related inflammatory biomarkers are associated with periodontitis has rarely been investigated.

Disulfidptosis and ferroptosis related genes define the immune microenvironment and NUBPL serves as a potential biomarker for predicting prognosis and immunotherapy response in bladder cancer.

Background: Ferroptosis and disulfidptosis are regulatory forms of cell death that play an important role in tumorigenesis and progression. However, few biomarkers about disulfidptosis and ferroptosis related genes (DFRGs) have been developed to predict the prognosis of bladder cancer (BC).

Methods: We conducted a bioinformatics analysis using public BC datasets to examine the prognostic significance of differentially expressed DFRGs.

Targeting senescence-associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes.

Tumour cell senescence can be induced by various factors, including DNA damage, inflammatory signals, genetic toxins, ionising radiation and nutrient metabolism. The senescence-associated secretory phenotype (SASP), secreted by senescent tumour cells, possesses the capacity to modulate various immune cells, including macrophages, T cells, natural killer cells and myeloid-derived suppressor cells, as well as vascular endothelial cells and fibroblasts within the tumour microenvironment (TME), and this modulation can result in either the promotion or suppression of tumorigenesis and progression. Exploring the impact of SASP on the TME could identify potential therapeutic targets, yet limited studies have dissected its functions.

Manufacturing of Bionic Adhesion Microstructure with Expanded Ends Based on Electroplating in the Restricted Area.

The organisms of animals with full spatial motion ability present fine and complex 3D structures, showing reliable adhesion ability to the substrate. As core issues, the design and manufacture of complex morphology are essential in bionic adhesion technology. Specifically, the end-expanded microstructure array of high adhesion under low preload has widespread potential in the nondestructive fixation and handling of fragile objects.

In Situ Formed 3,3',5,5'-Tetramethylbenzidine-Cu(I/II) Charge-Transfer Complex Intermediates Promoting Colorimetric Assay of Cr.

Developing a synthesis-free, multifunctional, and effective colorimetric assay system based on 3,3',5,5'-tetramethylbenzidine (TMB) oxidation is attractive yet challenging. Herein, we established a synergetic Cu/Cr-promoting strategy for TMB-based colorimetric detection of Cr. By introducing Cu, critical TMB····Cu(I/II)···TMB charge transfer complex (TMC) intermediates were in situ formed to reduce the activation energy of TMB oxidation, thereby accelerating Cr-mediated TMB oxidation.

CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant.

Functional enhancer annotation is critical for understanding tissue-specific transcriptional regulation and prioritizing disease-associated non-coding variants. However, unbiased enhancer discovery in disease-relevant contexts remains challenging. To identify enhancers pertinent to diabetes, we conducted a CRISPR interference (CRISPRi) screen in the human pluripotent stem cell (hPSC) pancreatic differentiation system.

Mitochondria-targeted sonodynamic modulation of neuroinflammation to protect against myocardial ischemia‒reperfusion injury.

Sympathetic hyperactivation and inflammatory responses are the main causes of myocardial ischemia‒reperfusion (I/R) injury and myocardial I/R-related ventricular arrhythmias (VAs). Previous studies have demonstrated that light-emitting diodes (LEDs) could modulate post-I/R neuroinflammation, thus providing protection against myocardial I/R injury. Nevertheless, further applications of LEDs are constrained due to the low penetration depth (<1 cm) and potential phototoxicity.