Publications by authors named "Jiahui Pei"

Article Synopsis
  • Excessive NADH levels in organisms are linked to several diseases, creating a need for efficient conversion to NAD.
  • Researchers developed multi-metal atom nanozymes (MANs) that mimic natural enzymes to facilitate this conversion, with a focus on the RhCo MAN demonstrating effective oxidase-like activity.
  • The RhCo MAN not only enhances NAD regeneration but also helps modulate macrophage polarization, potentially aiding in skin regeneration, while other variants show limited effectiveness in treating conditions like eczema.
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Neural electrodes are used for acquiring neuron signals in brain-machine interfaces, and they are crucial for next-generation neuron engineering and related medical applications. Thus, developing flexible, stable and high-resolution neural electrodes will play an important role in stimulation, acquisition, recording and analysis of signals. Compared with traditional metallic electrodes, electrodes based on graphene and other two-dimensional materials have attracted wide attention in electrophysiological recording and stimulation due to their excellent physical properties such as unique flexibility, low resistance, and high optical transparency.

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Natural enzymes are efficient and versatile biocatalysts but suffer in their environmental tolerance and catalytic stability. As artificial enzymes, nanozymes can improve the catalytic stability, but it is still a challenge to achieve high catalytic activity. Here, we employed atomic engineering to build the artificial enzyme named AuAg clusterzyme that hosts an ultrahigh catalytic activity as well as strong physiological stability via atom manipulation.

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Nanozymes have been widely used as highly active and stable arterial enzymes due to their controllable electronic transfer and unique catalytic reaction route. However, the development of nanozymes is hindered by their ambiguous structure, insufficient activity and inadequate substrate selectivity. In comparison, single-atom nanozymes (SAzymes) hold superior catalytic activity 10-100 times higher than conventional nanozymes by maximizing the utilization of metal atom dispersion, and exhibit versatile catalytic selectivity through precisely adjusting the atom spatial configuration.

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