Publications by authors named "Jiahui Luo"

Background: Chronic kidney disease (CKD) is a progressive condition that arises from diverse etiological factors, resulting in structural alterations and functional impairment of the kidneys. We aimed to establish the Anoikis-related gene signature in CKD by bioinformatics analysis.

Methods: We retrieved 3 datasets from the Gene Expression Omnibus (GEO) database to obtain differentially expressed genes (DEGs), followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) of them, which were intersected with Anoikis-related genes (ARGs) to derive Anoikis-related differentially expressed genes (ARDEGs).

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To elucidate the mechanism by which pre-aggregation and miscibility matching govern the active layer morphology in non-fullerene organic solar cells, chloroform (CF) and -xylene (OX) were used as solvents, while D18 and N2200 were incorporated as third components into the PM6:L8-BO system. The incorporation of D18 enhanced device performance, whereas the addition of N2200 reduced device performance. Based on surface energy analysis, the free energies of pure components and binary blends in different solvents were calculated, showing that the Gibbs free energies of D18, PM6 and L8-BO exhibited better pre-aggregation matching.

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We consider the periodic behavior of the generalized Chazy differential equation x⃛+|x|qx¨+k|x|qxx˙2=0, where q is a positive integer and k is a real number. We give a pure analysis on the existence of non-trivial periodic solutions for k=q+1 and the non-existence of them for k≠q+1. Our method is based on considering the projections of the orbits onto the phase plane (x,x˙).

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  • Industrial green and low-carbon transformation is essential for China's Carbon peaking and neutrality goals, facilitated by environmental regulation policies.* -
  • Three types of environmental regulation policies—command-type, investment-type, and expense-type—are analyzed using data from 30 provinces between 1997 and 2021 to assess their impact on industrial transformation.* -
  • The study finds that command and investment-type regulations initially promote, then hinder, green transformation, while expense-type regulations follow an opposite trend; combined effects of these regulations enhance transformation through innovation.*
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  • Improving feed efficiency and reproductive vitality in late-stage egg-laying hens is crucial for extending their productive cycle and enhancing egg quality, and a new flavonoid (KLF) was tested for its effects on this.
  • The study involved 360 Hy-Line Brown layer hens, split into control and varying KLF supplementation groups, to evaluate metrics like egg production, egg weight, and egg quality characteristics during treatment.
  • Results showed that KLF supplementation reduced deformed eggs and increased eggshell strength, particularly at 0.6% KLF, while also promoting beneficial probiotics and interacting with hypothalamic gene expressions related to egg quality.
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  • - The study analyzed the participation and detection rates of advanced colorectal neoplasms in multiple rounds of CRC screening using fecal immunochemical tests, synthesizing evidence from 19 studies involving over 2.2 million participants.
  • - Results showed that participation in screening increased over time, reaching approximately 78% for annual screenings, while detection rates also escalated, but the benefits diminished with each subsequent round.
  • - The research suggests that while participation trends are positive, the effectiveness of detecting CRC may plateau, indicating a need for tailored screening strategies to enhance efficiency and reduce costs.
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Adipose tissue macrophages (ATMs) play important roles in maintaining adipose tissue homeostasis and orchestrating metabolic inflammation. Given the extensive functional heterogeneity and phenotypic plasticity of ATMs, identification of the authentically pathogenic ATM subpopulation under obese setting is thus necessitated. Herein, we performed single-nucleus RNA sequencing (snRNA-seq) and unraveled a unique maladaptive ATM subpopulation defined as ATF4PDIA3ACSL4CCL2 inflammatory and metabolically activated macrophages (iMAMs), in which PDIA3 is required for the maintenance of their migratory and pro-inflammatory properties.

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  • The study investigates the rising incidence of early-onset colorectal cancer (EOCRC) compared to late-onset colorectal cancer (LOCRC) and the influence of blood glucose levels on these cancers, using data from over 500,000 participants across two cohorts.
  • Participants with higher blood glucose levels exhibited an increased risk of both EOCRC and LOCRC, with a significantly stronger association found for EOCRC, particularly at glucose levels above 7.0 mmol/L.
  • The findings suggest a need for better glucose management in younger populations to potentially reduce their risk of colorectal cancer.
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Background: Evidence on the long-term benefits and cost-effectiveness of colorectal cancer (CRC) screening strategies in China remains limited. This modelling study aims to address this issue for various CRC screening strategies in China between 2020 and 2060.

Methods: Using a previously developed microsimulation model (MIMIC-CRC) with Chinese epidemiological data, we evaluated four CRC screening strategies targeting population aged 45-74 years: no screening, colonoscopy every 10 years, biennial faecal immunochemical testing (FIT), and a roll-out FIT screening strategy.

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  • - The study focuses on the limbus's elasticity, which is important for eye health, but has not been thoroughly researched.
  • - Researchers used a technique called acoustic radiation force optical coherence elastography (ARF-OCE) to measure the limbus's biomechanical properties at different eye pressures and validated it with models.
  • - Findings revealed that ARF-OCE helps visualize the limbus's elasticity, which could improve the diagnosis of eye conditions by identifying variations in elasticity related to ocular diseases.
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Fluorescence detection has always suffered from high background fluorescence from real samples such as milk. Therefore, cumbersome pretreatments of samples were necessary to remove the fluorescent substances but led to long processing times and low efficiency. Time-resolved luminescence detection is a powerful technique for eliminating short-lived background fluorescence without additional pretreatments.

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High salt (HS) consumption is a risk factor for multiple autoimmune disorders via disturbing immune homeostasis. Nevertheless, the exact mechanisms by which HS exacerbates rheumatoid arthritis (RA) pathogenesis remain poorly defined. Herein, we found that heightened phosphorylation of PDPK1 and SGK1 upon HS exposure attenuated FoxO1 expression to enhance the glycolytic capacity of CD4 T cells, resulting in strengthened Th17 but compromised Treg program.

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Quantifying the biomechanical properties of the tongue is significant for early diagnosis of tongue carcinoma. Therefore, an intraoral optical coherence elastography system based on a miniature probe was proposed here to evaluate the viscoelasticity of tongue for the first time. Results of experiments with Sprague-Dawley rats indicate that considerable elasticity diversity occurred between cancerous and normal tongues, and the corresponding ratio of their Young's modulus was evaluated to be 3.

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Due to their compact size and exceptional sensitivity at room temperature, magnetoresistance (MR) sensors have garnered considerable interest in numerous fields, particularly in the detection of weak magnetic signals in biological systems. The "magnetrodes", integrating MR sensors with needle-shaped Si-based substrates, are designed to be inserted into the brain for local magnetic field detection. Although recent research has predominantly focused on giant magnetoresistance (GMR) sensors, tunnel magnetoresistance (TMR) sensors exhibit a significantly higher sensitivity.

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Dysregulated T cell activation underpins the immunopathology of rheumatoid arthritis (RA), yet the machineries that orchestrate T cell effector program remain incompletely understood. Herein, we leveraged bulk and single-cell RNA sequencing data from RA patients and validated protein disulfide isomerase family A member 3 (PDIA3) as a potential therapeutic target. PDIA3 is remarkably upregulated in pathogenic CD4 T cells derived from RA patients and positively correlates with C-reactive protein level and disease activity score 28.

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Objectives: This study aimed to identify symptom clusters in lung cancer patients undergoing chemotherapy and the central and bridge symptoms within each symptom cluster.

Methods: In this cross-sectional study, 1,255 patients with lung cancer were recruited through convenience sampling at Nanfang Hospital. Patient symptom burden was assessed using the M.

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Background: With social transformation, rapid economic development and deepening awareness of psychological health in China, people's demand for psychological health services is becoming increasingly urgent. A key challenge for Chinese medical organizations is to train enough qualified psychological care nurses. A greater understanding of psychological care competences (PCC) can help in clinical nurse selection, training, and assessment.

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At present, percutaneous surgery is widely used to treat thoracolumbar fractures. However, the actual safety, feasibility, and effectiveness of percutaneous surgery are not clear. Through systematic review and meta-analysis, we compared the efficacies of percutaneous pedicle screw fixation and open pedicle screw fixation in the treatment of thoracolumbar fractures without nerve root symptoms.

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Background: Patients with advanced cancer may experience symptom clusters during treatment (eg, fatigue, pain, sleep disturbance, depression). Understanding the characteristics and factors associated with symptom cluster classes among this patient population is essential for effective symptom management.

Objective: The aims of this study were to identify symptom cluster (fatigue-pain-sleep disturbance-depression) classes and explore influencing factors in patients with advanced cancer during the treatment.

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Spinal gout is a rare occurrence, and the combination of gout with lumbar spondylolysis has not been reported. We present a unique case involving a 29-year-old male who complained of low back pain for 1 month. Computed tomography and magnetic resonance imaging revealed articular subchondral erosions and a mass in the left L5-S1 facet joints.

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Three new cadinene sesquiterpenoids -, were isolated from the aerial sections of using various chromatographic techniques. Their structures were characterised by comprehensive spectroscopic investigations (including 1D, 2D-NMR and HRMS), and single crystal X-ray diffraction. The cytotoxic activity of new compounds - were evaluated by testing tumour growth inhibitory rate against five human tumour cell lines, HL-60, A-549, SMMC-7721, MDA-MB-231, and SW480.

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The scleral elasticity is closely related with many ocular diseases, but the relevant research is still insufficient. Here, we utilized optical coherence elastography to carefully study biomechanical properties of the sclera at different positions and under different intraocular pressures. Meanwhile, elastic wave velocity and Young's modulus of each position were obtained using a phase velocity algorithm.

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Independent component analysis (ICA) is widely used in the extraction of fetal ECG (FECG). However, the amplitude, order, and positive or negative values of the ICA results are uncertain. The main objective is to present a novel approach to FECG recognition by using a deep learning strategy.

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Hydrogen sulfide (HS) is one of the most irritant gases present in rearing stalls that suppress broilers' healthy growth, which is seriously required an effective alleviation method. In this study, Lactobacillus was supplemented to investigate the alleviative effects on broilers reared under consecutive HS exposure. A total of 180 healthy 1-day-old male AA broilers with similar body weight (40.

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Synopsis of recent research by authors named "Jiahui Luo"

  • - Jiahui Luo's research focuses on the intersection of environmental policies, health, and biomedicine, exploring topics ranging from industrial transformations related to green practices to the biological mechanisms of disease and treatment.
  • - Recent studies include a systematic review on colorectal cancer screening efficacy, identifying optimal strategies for population health, and investigating the physiological impacts of gut-brain interactions on egg quality in poultry.
  • - Luo's work also delves into adipose tissue macrophage behavior in obesity, providing insights into inflammatory processes, and employs advanced imaging technologies to assess the biomechanical properties of ocular structures, enhancing understanding of disease states and treatment responses.

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