Bullying victimization and self-harm in adolescents: The roles of emotion regulation and bullying peer norms.

Background: While prior research has suggested that experiencing bullying victimization increases the risk of self-harm, the exact role of intrapersonal emotion regulation and bullying peer norms in contributing to this association are not fully understood.

Objective: This study examined the mediating effects of cognitive reappraisal and expressive suppression and the moderating effects of bullying descriptive and popularity norms on the association between bullying victimization and self-harm.

Participants And Setting: A total of 3545 Chinese adolescents (52.

Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell-derived spinal cord progenitor cells.

Background: The emergence of induced pluripotent stem cells (iPSCs) offers a promising approach for replacing damaged neurons and glial cells, particularly in spinal cord injuries (SCI). Despite its merits, iPSC differentiation into spinal cord progenitor cells (SCPCs) is variable, necessitating reliable assessment of differentiation and validation of cell quality and safety. Phenotyping is often performed via label-based methods including immunofluorescent staining or flow cytometry analysis.

FeNi-Based Aerogels Containing FeNi Nanoclusters Embedded with a Crystalline-Amorphous Heterojunction as High-Efficiency Oxygen Evolution Catalysts.

In green hydrogen production via water electrolysis, catalysts with multiscale nanostructures synthesized by compositing micro-heterojunctions and nanoporous structures exhibit excellent electrocatalytic oxygen evolution reaction (OER) performance. Moreover, they are the most promising non-noble metal catalysts. Herein, FeNi-based aerogels with a three-dimensional nanoporous structure and amorphous matrix embedded with FeNi nanoclusters were synthesized via wet chemical reduction coprecipitation.

Radiosynthesis and evaluation of a novel F-labeled tracer for PET imaging of glycogen synthase kinase 3.

Glycogen synthase kinase 3 (GSK3) is a multifunctional serine/threonine kinase family that regulates diverse biological processes including glucose metabolism, insulin activity and energy homeostasis. Dysregulation of GSK3 is implicated in the development of several diseases such as type 2 diabetes mellitus, Alzheimer's disease (AD), and various cancer types. In this study, we report the synthesis and evaluation of a novel positron emission tomography (PET) ligand compound 28 (codenamed [F]GSK3-2209).

Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways.

The study aimed to investigate the impact of low-intensity pulsed ultrasound (LIPUS) on human urinary-derived stem cells (hUSCs) viability within three-dimensional (3D) cell-laden gelatin methacryloyl (GelMA) scaffolds. hUSCs were integrated into GelMA bio-inks at concentrations ranging from 2.5% to 10% w/v and then bioprinted using a volumetic-based method.

Development of a Candidate C-Labeled Selective Phosphodiesterase 1 Radioligand for Positron Emission Tomography.

Phosphodiesterases (PDEs) constitute a superfamily of phosphohydrolytic enzymes that regulate intracellular second messenger signaling by hydrolyzing cyclic adenosine monophosphate and cyclic guanosine monophosphate. Among the 11 subfamilies of PDEs, phosphodiesterase 1 (PDE1) stands out due to its broad implications in central and peripheral pathologies. There are three subtypes of PDE1: PDE1A, PDE1B, and PDE1C.

Discovery of 4-(4-(3-(1-(2-(piperidin-1-yl)ethyl)-1H-benzo[d]imidazole-2-yl)isoxazol-5-yl)phenyl)morpholine as a novel c-Myc inhibitor against lung cancer in vitro and in vivo.

The critical role of c-Myc as a driving factor in the development and progression of lung cancer establishes it as a pivotal target for anti-lung cancer therapeutic research. In our previous study, we reported on the discovery of D347-2761, a novel small-molecule inhibitor that specifically targets the unstable domain of c-Myc and disrupts the c-Myc/Max heterodimer. To enhance targeted therapies further, we conducted an extensive structural analysis and designed a series of innovative benzimidazole derivatives.

Self-assembled carrier-free formulations based on medicinal and food active ingredients.

The popularity of medicinal plants, which have a unique system and are mostly used in compound form for the prevention and treatment of a wide range of diseases, is growing worldwide. In recent years, with advances in chemical separation and structural analysis techniques, many of the major bioactive molecules of medicinal plants have been identified. However, the active ingredients in medicinal plants often possess chemical characteristics, including poor water solubility, stability and bioavailability, which limit their therapeutic applications.

The extract from Quzhou Aurantii Fructus attenuates cough variant asthma through inhibiting the TRPV1/Ca/NFAT/TSLP pathway and ferroptosis via TRPV1 mediation in ovalbumin-induced mice.

Ethnopharmacological Relevance: Cough variant asthma (CVA), a prevalent chronic inflammatory disease, is the most common cause of chronic cough. Over the years, the aqueous extract of Quzhou Aurantii Fructus (QAFA) has been widely used to treat respiratory diseases, particularly cough.

Aim Of The Study: This study aimed to elucidate the therapeutic effect of QAFA on allergen-induced CVA, providing deep insights into the underlying mechanisms.

Vitamin C intake and osteoarthritis: findings of NHANES 2003-2018 and Mendelian randomization study.

Background: The role of vitamin C in osteoarthritis (OA) is still a subject of debate. Our aim was to combine the National Health and Nutrition Examination Survey (NHANES) and MR studies to explore the relationship between vitamin C intake and OA.

Methods: Clinical information on participants during NHANES 2003-2018 was collected and the relationship between vitamin C intake and OA risk was assessed using logistic regression modelling.

Highly Efficient Organic/Silicon Hybrid Solar Cells with a MoO Capping Layer.

Organic/Si hybrid solar cells have attracted considerable attention for their uncomplicated fabrication process and superior device efficiency, making them a promising candidate for sustainable energy applications. However, the efficient collection and separation of charge carriers at the organic/Si heterojunction interface are primarily hindered by the inadequate work function of poly (3,4-ethylenedioxythiophene): poly (styrenesulfonate) (PEDOT:PSS). Here, the application of a high-work-function MoO film onto the n-Si/PEDOT:PSS surface leads to a notable enhancement in the device's built-in potential.

Scalable Fabrication of High-Performance Perovskite Solar Cell Modules by Mediated Vapor Deposition.

Perovskite solar cells (PSCs) can enable renewable electricity generation at low levelized costs, subject to the invention of an economically feasible technology for their large-scale fabrication, like vapor deposition. This approach is effective for the fabrication of small area (<1 cm) PSCs, but its scale-up to produce high-efficiency larger area modules has been limited by a severe imbalance between the vapor-solid reaction kinetics and the mass-transport of the volatile ammonium salt precursor. In this study, an amidine-based low-dimensional perovskite is introduced as an intermediate of the solid-vapor reaction to help resolve this limitation.

Fluorogenic target competitors for developing label-free and sensitive folding-unswitching aptamer sensors.

Background: Aptamers have aroused tremendous applications in sensors, drug deliveries, diagnosis, and therapies. In particular, target-induced global structure switching of aptamers has been widely used to develop selective sensors. However, fluorophore and/or quencher modification, sequence elongation, and nano-interface adsorption are required to design such global structure-switching aptamer sensors (SSAS) in order to signal target binding events.

A Dual-Branch Cross-Modality-Attention Network for Thyroid Nodule Diagnosis Based on Ultrasound Images and Contrast-Enhanced Ultrasound Videos.

Contrast-enhanced ultrasound (CEUS) has been extensively employed as an imaging modality in thyroid nodule diagnosis due to its capacity to visualise the distribution and circulation of micro-vessels in organs and lesions in a non-invasive manner. However, current CEUS-based thyroid nodule diagnosis methods suffered from: 1) the blurred spatial boundaries between nodules and other anatomies in CEUS videos, and 2) the insufficient representations of the local structural information of nodule tissues by the features extracted only from CEUS videos. In this paper, we propose a novel dual-branch network with a cross-modality-attention mechanism for thyroid nodule diagnosis by integrating the information from tow related modalities, i.

IPHM: Incremental periodic high-utility mining algorithm in dynamic and evolving data environments.

Periodic high-utility itemset (PHUI) mining can extend beyond the conventional approach of high-utility itemset mining by uncovering recurring customer purchase behaviors common in real-life scenarios (e.g., buying apples and oranges every three days or weekly).

Dual-channel discrimination of two lethal chemical warfare agents using an ESIPT-ICT-based fluorescent probe.

Among all kinds of chemical warfare agents, only cyanide and nerve agents can cause massive mortality at low concentrations. In this work, a dual-channel fluorescent probe CWAs-Thia capable of detecting cyanide and nerve agents is presented. The two reactive recognition units, pyridine and the thiazole-2-carbonyl group, of the probe for cyanide and nerve agents, respectively, produced red and blue fluorescent responses, respectively, which were attributed to excited-state intramolecular proton transfer and intramolecular charge transfer.

Why rejection sensitivity leads to adolescents' loneliness: Differential exposure, reactivity, and exposure-reactivity models.

Introduction: Rejection sensitivity is considered a risk factor for loneliness; however, the underlying mechanisms remain unknown. Adopting the constructs of exposure, reactivity, and exposure-reactivity from the personality framework, this study investigated three models of rejection sensitivity, bullying victimization, and loneliness to reveal why rejection sensitivity leads to loneliness among Chinese early adolescents.

Methods: Using a longitudinal design, three-wave data were obtained (with approximately 6-month intervals) from 2381 Chinese early adolescents (51.