Food-derived DPP4 inhibitors: Drug discovery based on high-throughput virtual screening and deep learning.

Dipeptidyl peptidase-4 (DPP-4) is a critical target for the treatment of type 2 diabetes. This study outlines the development of six compounds derived from food sources and modified to create promising candidates for the treatment of diabetes. These compounds were identified through a combination of virtual screening, deep learning algorithms, ADMET characterization assessment, and molecular dynamics simulations.

Identification of DDR1 Inhibitors from Marine Compound Library Based on Pharmacophore Model and Scaffold Hopping.

Ulcerative colitis (UC) is a chronic inflammatory condition that affects the intestines. Research has shown that reducing the activity of DDR1 can help maintain intestinal barrier function in UC, making DDR1 a promising target for treatment. However, the development of DDR1 inhibitors as drugs has been hindered by issues such as toxicity and poor binding stability.

Kushenol O Regulates GALNT7/NF-κB axis-Mediated Macrophage M2 Polarization and Efferocytosis in Papillary Thyroid Carcinoma.

Background: The incidence of papillary thyroid carcinoma (PTC) is on the rise globally. It is frequently associated with early lymphatic metastasis, and the poor prognosis tends to be poor once metastasis or recurrence occurs, even with current treatment modalities. Kushenol O, a novel extract derived from Sophora flavescens, has shown remarkable anticancer properties.

Identification of Marine-Derived SLC7A11 Inhibitors: Molecular Docking, Structure-Based Virtual Screening, Cytotoxicity Prediction, and Molecular Dynamics Simulation.

The search for anticancer drugs that target ferroptosis is a promising avenue of research. SLC7A11, a key protein involved in ferroptosis, has been identified as a potential target for drug development. Through screening efforts, novel inhibitors of SLC7A11 have been designed with the aim of promoting ferroptosis and ultimately eliminating cancer cells.

Pulse-doubling perovskite nanowire lasers enabled by phonon-assisted multistep energy funneling.

Laser pulse multiplication from an optical gain medium has shown great potential in miniaturizing integrated optoelectronic devices. Perovskite multiple quantum wells (MQWs) structures have recently been recognized as an effective gain media capable of doubling laser pulses that do not rely on external optical equipment. Although the light amplifications enabled with pulse doubling are reported based on the perovskite MQWs thin films, the micro-nanolasers possessed a specific cavity for laser pulse multiplication and their corresponding intrinsic laser dynamics are still inadequate.

Continuous-wave quasi-single-mode random lasing in CHNHPbBr perovskite films on patterned sapphire substrates.

We report intriguing continuous-wave quasi-single-mode random lasing in methylammonium lead bromide (CHNHPbBr) perovskite films synthesized on a patterned sapphire substrate (PSS) under excitation of a 532-nm laser diode. The random laser emission evolves from a typical multi-mode to a quasi-single-mode with increasing pump fluences. The full width at half-maximum of the lasing peak is as narrow as 0.

Emerging Trends in Electron Transport Layer Development for Stable and Efficient Perovskite Solar Cells.

Perovskite solar cells (PSCs) stand at the forefront of photovoltaic research, with current efficiencies surpassing 26.1%. This review critically examines the role of electron transport materials (ETMs) in enhancing the performance and longevity of PSCs.

Lasing properties and carrier dynamics of CsPbBr perovskite nanocrystal vertical-cavity surface-emitting laser.

All-inorganic lead halide perovskite nanocrystals (NCs) have been widely investigated as highly promising optical gain materials due to their compelling electrical and optical properties. Although many efforts have been carried out, a deep understanding of perovskite NC vertical-cavity surface-emitting lasers (VCSELs) is elusive, which is very important in the development of photoelectronic integrated circuits. Along these lines, in this work, a low lasing threshold (22 μJ/cm) single-mode VCSEL consisting of CsPbBr NCs film and two distributed Bragg reflectors was successfully constructed.

Process Accumulated 8% Efficient Cu ZnSnS -BiVO Tandem Cell for Solar Hydrogen Evolution with the Dynamic Balance of Solar Energy Storage and Conversion.

A process accumulated record solar to hydrogen (STH) conversion efficiency of 8% is achieved on the Cu ZnSnS -BiVO tandem cell by the synergistic coupling effect of solar thermal and photoelectrochemical (PEC) water splitting with the dynamic balance of solar energy storage and conversion of the greenhouse system. This is the first report of a Cu ZnSnS -BiVO tandem cell with a high unbiased STH efficiency of over 8% for solar water splitting due to the greenhouse device system. The greenhouse acts as a solar thermal energy storage cell, which absorbs infrared solar light and storage as thermal energy with the solar light illumination time, while thermoelectric device (TD) converts thermal energy into electric power, electric power is also recycled and added onto Cu ZnSnS -BiVO tandem cell for enhanced overall water splitting.

Effects of working pressure on the material and defect properties of SbS thin-film solar cells achieved by the VTD method.

Antimony sulfide (), an emerging material for photovoltaic devices, has drawn growing research interest due to its inexpensive and high-throughput device production. In this study, the material and defect properties of thin films prepared by the vapor transport deposition (VTD) method at different working pressures were studied. Solar cells based on a structure of //// were fabricated.

Effects of Copper Dopants on the Magnetic Property of Lightly Cu-Doped ZnO Nanocrystals.

To explore the origin of magnetism, the effect of light Cu-doping on ferromagnetic and photoluminescence properties of ZnO nanocrystals was investigated. These Cu-doped ZnO nanocrystals were prepared using a facile solution method. The Cu and Cu ions were incorporated into Zn sites, as revealed by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).

Effects of working pressure and power on photovoltaic and defect properties of magnetron sputtered SbSe thin-film solar cells.

Antimony selenide (${\text{Sb}_2}{\text{Se}_3}$SbSe) is an emerging material with potential applications in photovoltaics, while magnetron sputtering is an important method in material growth. In this study, ${\text{Sb}_2}{\text{Se}_3}$SbSe thin films, prepared by the magnetron sputtering technique with varied working pressures and sputtering powers, were fabricated into solar cells with a structure of $\text{glass}/\text{ITO}/\text{CdS}/{\text{Sb}_2}{\text{Se}_3}/\text{Au}$glass/ITO/CdS/SbSe/Au. The current density versus voltage measurements and x-ray diffraction were introduced to compare the photovoltaic and structural properties of the cell samples.

Effects of substrate temperature on material and photovoltaic properties of magnetron-sputtered SbSe thin films.

We studied the material and photovoltaic properties of SbSe thin films fabricated by a magnetron-sputtering method at different substrate temperatures. The films had good crystallinity at substrate temperatures over 300°C. The band-gap energies between 1.

Efficient and Hole-Transporting-Layer-Free CsPbI Br Planar Heterojunction Perovskite Solar Cells through Rubidium Passivation.

Recently, inorganic perovskite CsPbI Br has gained much attention for photovoltaic applications owing to its excellent thermal stability. However, low device performance and high open-voltage loss, which are the result of its intrinsic trap states, are hindering its progress. Herein, planar CsPbI Br solar cells with enhanced performance and stability were demonstrated by incorporating rubidium (Rb) cations.