Service quality evaluation of integrated health and social care for older Chinese adults in residential settings based on factor analysis and machine learning.

Objective: To evaluate the service quality of integrated health and social care institutions for older adults in residential settings in China, addressing a critical gap in the theoretical and empirical understanding of service quality assurance in this rapidly expanding sector.

Methods: This study employs three machine learning algorithms-Backpropagation Neural Networks (BPNN), Feedforward Neural Networks (FNN), and Support Vector Machines (SVM)-to train and validate an evaluative item system. Comparative indices such as Mean Squared Error, Mean Absolute Error (MAE), Mean Absolute Percentage Error (MAPE), and predictive performance metrics were employed to assess the models.

Dyes-encapsulated metal-organic cage as fluorescence sensor array for the auxiliary differential diagnosis of MCD and FSGS in early renal disorders.

Both minimal change disease (MCD) and focal segmental glomerular sclerosis (FSGS) are the pathological types of primary nephrotic syndrome (PNS) and cannot be readily distinguished owing to their highly similar clinical presentations. Currently, methods for clinical MCD and FSGS diagnosis still rely on invasive renal biopsy which impede rapid and accurate diagnosis for timely treatment management. In this study, a novel diagnostic strategy by introducing the dyes with spironolactone structure into the metal-organic cage to construct three dye@MOCs composites has been developed and employed as fluorescence sensor array for assisting in the auxiliary differential diagnosis of MCD and FSGS based on the distinguishable biothiols in urine.

Combining Liposomal Photocatalysts with Whole-Cell Catalysts for One-pot Photobiocatalysis.

Cooperative photobiocatalytic processes have seen extensive potentials for the synthesis of both bulk and fine chemicals owing to their versatility, eco-friendliness, and cost-effectiveness. Nevertheless, developing a universal and effective synthetic strategy compatible with both catalytic systems remains challenging. In this study, we explored cationic liposomes as biocompatible photocatalyst encapsulation systems and combined them with bacteria overexpressing enzymes for two-step and three-step cascade reactions.

Direct Visualization of Hepatitis C Virus RNA in Living Cells and Mice.

RNA virus infection is a global health issue with a significant economic burden. Direct visualization of the viral RNA genome in living cells is crucial for virological research and early clinical diagnosis. Thus, the need to continue research to find imaging toolkits is urgent.

RBM15 facilitates osimertinib resistance of lung adenocarcinoma through m6A-dependent epigenetic silencing of SPOCK1.

Lung cancer is the leading cause of cancer-related mortality globally. N6-methyladenosine (m6A) is the most abundant modification in mammalian mRNA and is involved in the biological regulation of tumors, including lung cancer. However, the role of m6A-related proteins, such as RNA-binding motif protein 15 (RBM15), in lung cancer progression remains largely unknown.

An advanced hydrogel dressing system with progressive delivery and layer-to-layer response for diabetic wound healing.

Wound healing in diabetic patients presents a significant challenge due to delayed inflammatory responses, which obstruct subsequent healing stages. In response, we have developed a progressive, layer-by-layer responsive hydrogel, specifically designed to meet the dynamic requirements of diabetic wounds throughout different healing phases. This hydrogel initiates with a glucose-responsive layer formed by boronate ester bonds between 4-arm-poly (ethylene glycol) succinimidyl glutarate (4arm-PEG-SG) and 3-aminophenylboronic acid.

Ionic Liquid-Based Grapeseed Oil Emulsion for Enhanced Anti-Wrinkle Treatment.

Objectives: To address the poor efficacy and percutaneous penetration of grape seed oil, ionic liquids and nanotechnology were combined to prepare a grape seed oil emulsion.

Methods: A novel Menthol-CoQ10 ionic liquid and ionic liquid based grapeseed oil emulsion were prepared and confirmed.

Results: The average size of the grapeseed oil emulsion was 218 nm, and its zeta potential was -33.

Boosting Fast Charging of Lithium-Metal Batteries via Weak Interactions Between Non-Solvating Solvents and Anions in High-Safety Eutectic Electrolytes.

Proper design of the solvation structure is crucial for the development of lithium metal batteries (LMBs). In this paper, the use of 1,2-Dimethoxyethane (DME) as a non-solvating cosolvent in amide-based eutectic electrolytes is proposed to address challenges related to high viscosity, high polarization, and low conductivity, thus enhancing the compatibility with lithium metal anodes. Through physical characterization combined with simulation calculations the existence of a weak interaction between DME and anions is confirmed, which promotes the dissociation of lithium salts and increases the Li transference number and diffusion coefficient, thus improving the fast charging performance of eutectic electrolytes.

Ionic liquid combined with cationic liposome co-delivers microphthalmia-associated transcription factor small interfering RNA to regulate melanogenesis.

Suppressing allele-specific genes using small interfering RNAs (siRNAs) can effectively whiten skin by influencing cellular gene and protein expression. Topical delivery of siRNA is a promising alternative to injections for RNA interference. However, the barrier function of the skin hinders the effective penetration of siRNA.

Topical Transdermal Administration of Supramolecular Self-Assembled Carnosine for Anti-Melanin and Anti-Aging.

The structure of natural proteins has inspired the hypothesis that L-carnosine (LC), acetyl carnosine (AC), and decarboxy carnosine (DC) self-assemble into highly bioactive carnosine with supramolecular structures. These structures are proposed to combat skin pigmentation and aging through the coordination of weak interactions between molecules. Simulations are conducted to ascertain the precise free energies of the potential supramolecular structures and to identify the equilibrium structure.

CircRNA: A new target for ischemic stroke.

Ischemic stroke, a clinical emergency and disease with a poor prognosis, has a negative impact on the survival index of patients. It is frequently precipitated by a multitude of risk factors, including trauma. Currently, there is a paucity of predictive indicators for early intervention.

Balancing Edge Defects and Graphitization in a Pt-Fe/Carbon Electrocatalyst for High-Power-Density and Durable Flow Seawater-Al/Acid Hybrid Fuel Cells and Zn-Air Batteries.

Overcoming the trade-off between the graphitization of the carbon substrate and enhanced electronic metal-support interaction (EMSI) and intrinsic activity of Pt-C catalysts remains a major challenge for ensuring the durable operation of energy conversion devices. This article presents a hybrid catalyst consisting of PtFe nanoparticles and single Pt and Fe atoms supported on N-doped carbon (PtFe@PtFe-N-C), which exhibits improved activities in hydrogen evolution and oxygen reduction reactions (HER and ORR, respectively) and has excellent durability owing to the high graphitization, rich edge defects, and porosity of the carbon in PtFe@PtFe-N-C, as well as strong EMSI between the PtFe nanoparticles and edge-defective carbon embedded with Pt and Fe atoms. According to theoretical calculations, the strong EMSI optimizes the H* adsorption-desorption and facilitates the adsorption OOH*, accelerating the HER and ORR processes.

Strong, tough, and freeze-tolerant all-natural cellulose-based ionic conductor enabled by multiscale cellulose networks.

Soft ionic conductors are widely used in flexible electronics. However, the simultaneous enhancement of their mechanical properties and ionic conductivity remains challenging. This paper reports the successful development of a strong and tough cellulose-based ionic conductor with exceptional mechanical properties and high ionic conductivity by in situ dissolution and reorganization of the fiber matrix of filter paper to create a multiscale structure.

Anti-inflammatory and antioxidant effects on skin based on supramolecular hyaluronic acid-ectoin.

We addressed the damage caused by internal and external factors on the skin, as well as the aging phenomenon caused by delayed repair after damage. We prepared supramolecular hyaluronic acid-ectoin (HA-ECT) by combining theoretical calculations and experimental research, using intermolecular forces between hyaluronic acid and ectoin. This supramolecule has good stability, safety, and skin permeability and can penetrate the stratum corneum of the skin, reaching the epidermis and dermis of the skin.

A New High-Performance Porous Carbon-Coated MnO/NaCO Cathode for Suppressing MnDissolution in Aqueous Zinc Ion Batteries.

Manganous-manganic oxide (MnO), akin to other manganese-based oxides, faces several critical challenges such as substantial capacity fading and limited rate performance due to its inferior electrical conductivity, in addition to the inevitable dissociation of Mn. To address these issues, we introduce for the first time a novel carbon-coated MnO/NaCO (MnO/NaCO/C) composite material. Comprehensive characterizations indicate that NaCO effectively curtails Mndissolution, enhances carbon encapsulation throughout charging/discharging cycles, and exposes additional active sites on the MnO/NaCO/C composite.

Transdermal delivery of elastin peptide assisted by betaine-based deep eutectic solvent to ameliorate skin photoaging.

The unique amino acid composition of elastin peptide (EP) makes it an excellent resource to obtain antioxidant peptides. It exhibits high elastase inhibitory activity with the potential to resist skin aging and is currently used in a many cosmetic products. However, the inherent low permeability of the skin limits its ability to penetrate the skin.

Development of an angle-adjustable photonic crystal fluorescence platform for sensitive detection of oxytetracycline.

We pioneered an angle-adjustable photonic crystal fluorescence platform (APC-Fluor) that integrates PCs, an angular resolution spectrometer and a strategically aligned laser source. This configuration, featuring a coaxial rotating swing arm, allows for precise control over the angles of incidence and emission. The presence of photonic crystal microcavities facilitates the dispersion of fluorescent materials and promotes the transition of electrons from the excited state to the lowest vibrational energy level.

Mitochondrial‑associated endoplasmic reticulum membrane interference in ovarian cancer (Review).

The mitochondria‑associated endoplasmic reticulum (ER) membrane (MAM), serving as a vital link between the mitochondria and ER, holds a pivotal role in maintaining the physiological function of these two organelles. Its specific functions encompass the participation in the biosynthesis and functional regulation of the mitochondria, calcium ion transport, lipid metabolism, oxidative stress and autophagy among numerous other facets. Scientific exploration has revealed that MAMs hold potential as effective therapeutic targets influencing the mitochondria and ER within the context of cancer therapy.

A new scale for older resident satisfaction with residential integrated care in China: Development and validation.

The factors that affect resident satisfaction with emerging residential integrated care for older people in China have been unclear due to a lack of validated instruments. Based on psychometric assessment procedures, we developed a new scale for older resident satisfaction with residential integrated care (SORSRIC). The scale was developed using a two-step process and a sample of 16 Chinese institutions and 333 residents.

Eutectogel Electrolyte Constructs Robust Interfaces for High-Voltage Safe Lithium Metal Battery.

Dramatic growth of lithium dendrite, structural deterioration of LiCoO (LCO) cathode at high voltages, and unstable electrode/electrolyte interfaces pose significant obstacles to the practical application of high-energy-density LCO||Li batteries. In this work, a novel eutectogel electrolyte is developed by confining the nonflammable eutectic electrolyte in a polymer matrix. The eutectogel electrolyte can construct a robust solid electrolyte interphase (SEI) with inorganic-rich LiF and LiN, contributing to a uniform Li deposition.

Self-adjuvanting polymeric nanovaccines enhance IFN production and cytotoxic T cell response.

Vaccines represent one of the most powerful and cost-effective innovations for controlling a wide range of infectious diseases caused by various viruses and bacteria. Unlike mRNA and DNA-based vaccines, subunit vaccines carry no risk of insertional mutagenesis and can be lyophilized for convenient transportation and long-term storage. However, existing adjuvants are often associated with toxic effect and reactogenicity, necessitating expanding the repertoire of adjuvants with better biocompatibility, for instance, designing self-adjuvating polymeric carriers.