Perforated imprinting on high moisture meat analogue confers long range mechanical anisotropy resembling meat cuts.

Meat cuts, when cooked and masticated, separate into fibrous structures because of the long-range mechanical anisotropy (LMA) exhibited by muscle fascicles, which is not fully recapitulated in alternative proteins produced using molecular alignment technology like high moisture extrusion. We have developed a scalable perforated micro-imprinting technology to greatly enhance LMA in high moisture meat analogue (HMMA). By imprinting 1 mm thick HMMA sheets with perforated patterns (optimized by AI), we observed up to 5 × more anisotropic separation of fibrous structures in a one-dimensional pulling LMA analysis, to match the fibrousness of the cooked chicken breast, duck breast, pork loin and beef loin.

Structural-color meta-nanoprinting embedding multi-domain spatial light field information.

Recently, multifunctional metasurface has showcased its powerful functionality to integrate nanoprinting and holography, and display ultracompact meta-images in near- and far-field simultaneously. Herein, we propose a tri-channel metasurface which can further extend the meta-imaging ranges, with three independent images located at the interface, Fresnel and Fourier domains, respectively. Specifically, a structural-color nanoprinting image is decoded right at the interface of the metasurface, enabled by varying the dimensions of nanostructures; a Fresnel holographic image and another Fourier holographic image are present at the Fresnel and Fourier (far-field) domains, respectively, enabled by geometric phase.

Total parietal peritonectomy and multivisceral resection for extensive cytoreductive surgery in pseudomyxoma peritonei: En bloc "Rolled-up carpet" technique and perioperative and oncologic outcomes.

Background: Patients diagnosed with pseudomyxoma peritonei (PMP) of appendiceal origin typically present with high tumor burden and require extensive cytoreductive surgery (CRS) to achieve optimal cytoreduction. This study describes an en bloc "rolled-up carpet" surgical technique for total parietal peritonectomy and multivisceral resection while also analyzing the perioperative and tumor outcomes of this technique.

Methods: The study reviewed the data of 7 patients underwent en bloc "rolled-up carpet" extensive CRS between August 2020 and April 2023.

Surface Involvement in the Boosting of Chiral Organocatalysts for Efficient Asymmetric Catalysis.

Nanostructures with curved surfaces and chiral-directing residues are highly desirable in the synthesis of asymmetric chemicals, but they remain challenging to synthesize without using unique templates due to the disfavored torsion energy of twisted architectures toward chiral centers. Here, a strategy for the facile fabrication of highly cured capsule-shaped catalysts with chiral interiors by the amplification of molecular chirality via the irreversible cross-linking of 2D asymmetric laminates is presented. The key to the success of these irregular 2D layers is the use of hierarchical assembly of chiral macrocycles, which can exactly regulate the cured nanostructures as well as asymmetric catalysis.

Laser weld spot detection based on YOLO-weld.

Laser weld point detection is crucial in modern industrial manufacturing, yet it faces challenges such as a limited number of samples, uneven distribution, and diverse, irregular shapes. To address these issues, this paper proposes an innovative model, YOLO-Weld, which achieves lightweight design while enhancing detection accuracy. Firstly, a targeted data augmentation strategy is employed to increase both the quantity and diversity of samples from minority classes.

Mycobacterium tuberculosis short mutant H37Rv-S with reduced growth adaptability is more readily recognized by the host immune system.

Mycobacterium tuberculosis (Mtb) is the bacterium responsible for causing Tuberculosis (TB) and understanding its mechanisms of virulence, persistence, and pathogenesis is a global research priority. Attenuated strains of Mtb are valuable tools for investigating the genes and proteins involved in these processes. In this study, we identified an Mtb mutant, H37Rv-S, which exhibits a shorter mycelium, smoother colony, slower growth, and reduced antibiotics resistance compared to the wild-type strain H37Rv.

Low molecular weight fucoidan induces M2 macrophage polarization to attenuate inflammation through activation of the AMPK/mTOR autophagy pathway.

Fucoidan, a sulfated polysaccharide with a complex structure, has gradually become the focus of biomedical research due to its remarkable biological activity and low toxicity. In this research, it was noted that low molecular weight fucoidan (LMWF) exhibited significant antimicrobial effects on Methicillin-resistant Staphylococcus aureus (MRSA) and promoted polarization towards M2 macrophages, leading to a substantial reduction in inflammatory responses within the lipopolysaccharide (LPS)-activated macrophages. We further explored the mechanism underlying the anti-inflammation activity.

Upper limit on the polarization-assisted amplitude modulation capability of cascaded single-cell wave-plate-like metasurfaces.

The Jones matrix method offers a robust framework for designing polarization multiplexed metasurfaces (PMMs). Traditional PMMs design involves initially defining functions and working channels, then mapping feature functions to adjustable parameters of metasurfaces. However, this approach makes it difficult to predict how working channels affect metasurface features.

Comparative Genomics Provides Insights into Adaptive Evolution and Demographics of Bats.

Bats possess a range of distinctive characteristics, including flight, echolocation, impressive longevity, and the ability to harbor various zoonotic pathogens. Additionally, they account for the second-highest species diversity among mammalian orders, yet their phylogenetic relationships and demographic history remain underexplored. Here, we generated de novo assembled genomes for 17 bat species and 2 of their mammalian relatives (the Amur hedgehog and Chinese mole shrew), with 12 genomes reaching chromosome-level assembly.

An efficient leakage power optimization framework based on reinforcement learning with graph neural network.

Threshold voltage ( ) assignment is convenient for leakage optimization due to the exponential relation between leakage power and by swapping logic cells without routing effort. However, it poses great challenge in large scale circuit design as an NP-hard problem. Machine learning-based approaches have been proposed to solve this problem, aiming to achieve well tradeoff between leakage power reduction and runtime speed up without new induced timing violation.

Time course of visual attention in rats by atomic magnetometer.

Atomic magnetometer (AM) is utilized to non-invasively detect event-related magnetic fields (ERMFs) evoked by visual stimuli in rats. The aim of this study was to investigate the relationship between N2-like amplitude and visual attention. To achieve this, we combined the AM with a visual stimulation system and employed the passive single-stimulus paradigm.

Wearable Multifunctional Hydrogel for Oral Microenvironment Visualized Sensing Coupled with Sonodynamic Bacterial Elimination and Tooth Whitening.

Bacterial-driven dental caries and tooth discoloration are growing concerns as the most common oral health problems. Current diagnostic methods and treatment strategies hardly allow simultaneous early detection and non-invasive treatment of these oral diseases. Herein, a wearable multifunctional double network hydrogel combined with polyaniline and barium titanate (PANI@BTO) nanoparticles is developed for oral microenvironment visualized sensing and sonodynamic therapy.

Gut-Liver Axis: Modulating the Gut Microbiota and Its Metabolic Products as a Potential Therapeutic Strategy for the Treatment of Hepatic Ischemia-Reperfusion Injury.

Hepatic ischemia-reperfusion injury (HIRI) is a major complication reported in various clinical scenarios such as liver transplantation (LTx), hepatectomy, and acute hepatic insult. This condition affects the restoration of hepatic functionalities post-LTx. Contemporary scientific inquiries have highlighted the involvement of intestinal microbiota and their metabolic by-products in the initiation and progression of HIRI.

Insights into the intestinal microbiota of and in the Yangtze River estuary.

The gut microbiota plays a crucial role in food webs, carbon cycling, and related elements. and are two important forage species in the Yangtze River estuary with extremely similar living habits and morphological characteristics. Exploring the microorganisms in the guts of these two shrimp species can help us understand the survival status of forage species and gut microbiota in the Yangtze River estuary.

Identifying Mechanism of RSV for the Treatment of COVID-19 and Idiopathic Pulmonary Fibrosis via Suppressing Inflammation Response Through IL-17 Signaling Pathway from the Perspectives of in silico Study.

Background: Both coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis (IPF) could cause severe pulmonary injury and have extremely dismal prognoses with a high risk of mortality. Resveratrol (RSV), a natural polyphenol, has promising potential in the treatment of viral infection and pulmonary fibrosis.

Objective: The purpose of this research was to investigate the unclear mechanism of RSV as an anti-COVID-19 and IPF therapy.

Siwu tablet attenuates high fructose-induced glomerular podocyte senescence in rats through increasing Nup155 to promote INO80 mRNA nuclear export.

Ethnopharmacological Relevance: Siwu tablet (SWT), derived from a traditional Chinese medicinal formula named Siwu decoction, is widely used for blood deficiency syndrome. Siwu decoction and its derived formulas have been proven to improve renal anemia and prevent senescence. Whether SWT prevents glomerular podocyte senescence and the underlying molecular mechanism remains unknow.

AUV SLAM method based on SO-CFAR and ADT feature extraction.

Due to the exceptional detection capabilities, the forward-looking sonar could be adopted in simultaneous localization and mapping (SLAM) for autonomous underwater vehicle (AUVs). This paper primarily investigates the application of the factor graph optimization SLAM algorithm based on feature maps in AUV. It achieves this by combining the smallest of constant false alarm rate (SO-CFAR) and adaptive threshold (ADT) to filter noise from the forward-looking sonar and extract feature point clouds.

Ionic Liquid/Deep Eutectic Solvent-Mediated Calcining Synthesis of Cobalt-Based Electrocatalysts for Water Splitting.

The recent advancements of ionic liquids (ILs) and deep eutectic solvents (DESs) in the synthesis of cobalt-based catalysts for water splitting is reviewed. ILs and DESs possess unique physical and chemical properties, serving as solvents, templates, and reagents. Combined with calcination techniques, their advantages can be fully leveraged, enhancing the stability and activity of resulted catalysts.

Self-Assembled Monolayer Suppresses Interfacial Reaction between NiO and Perovskite for Efficient and Stable Inverted Inorganic Perovskite Solar Cells.

Inorganic NiO has attracted tremendous attention in organic-inorganic hybrid perovskite solar cells (PSCs) in recent years but is relatively less used in all-inorganic PSCs. In this study, we have discovered and confirmed the detrimental interfacial reaction between NiO and DMAI-containing CsPbI inorganic perovskites. Thus, a self-assembled monolayer, Br-2PACz, is employed to modify the NiO surface to obstruct the adverse interfacial reaction and further improve the device performance.