Itaconic acid facilitates inflammation abatement and alleviates liver ischemia-reperfusion injury by inhibiting NF-κB/NLRP3/caspase-1 inflammasome axis.

Background: Ischemia-reperfusion injury (IRI) severely limits the efficacy and donor source of liver transplantation, and the crucial step in alleviating it is to control inflammation. Itaconic acid is a metabolite produced by intrinsic immune cells (especially macrophages) in the inflammatory state and can promote inflammation subsidence. However, its role in liver ischemia-reperfusion is insufficiently clarified.

Comparison of Two Donor Liver Procurement Methods for Treatment of Pediatric Acute Liver Failure.

Background: To evaluate the difference and efficacy of two donor liver procurement methods for treatment of pediatric acute liver failure (PALF) by living donor liver transplantation (LDLT).

Methods: A total of 17 patients (12 men, 5 women) with PALF who underwent LDLT in our hospital between October 2016 and October 2020, and prognostic efficacy of donors and recipients using two donor liver procurement methods were analyzed.

Results: The donors and recipients were both divided into laparoscopic (7 cases) and open (10 cases) donor liver procurement groups.

He . 2018 is a later heterotypic synonym of Park . 2018.

L53 was compared with MM-14 to examine the taxonomic relationship between the two type strains. The 16S rRNA gene sequence of L53 had complete similarity (100.0%) to that of MM-14.

Qu . 2020 is a later heterotypic synonym of Klykleung . 2020.

WYY166 was compared with PA1-10 to examine the taxonomic relationship between the two type strains. The 16S rRNA gene sequence of WYY166 had high similarity (99.9 %) to that of PA1-10.

sp. nov., a marine bacterium isolated from a tidal sediment.

A Gram-stain-positive, endospore-forming, motile and rod-shaped bacterium, designated as strain DSL-17, was isolated from a tidal sediment of the East China Sea and characterized phylogenetically and phenotypically. The strain could grow at 16-47 °C (optimum 37 °C), at pH 6.0-10.

sp. nov., a novel piezophile isolated from hadopelagic water of the Mariana Trench and reclassification of as a later heterotypic synonym of .

A novel marine Gram-stain-negative, non-motile, aerobic and rod-shaped bacterium, designated as strain MT-229, was isolated from the deep seawater in the Mariana Trench and characterized phylogenetically and phenotypically. Bacterial optimal growth occurred at 30 °C (ranging 10-40 °C), pH 6 (ranging 3-11) and with 11 % (w/v) NaCl (ranging 0-17 %). Strain MT-229 was a piezophile, growing optimally at 20 MPa (range 0.

sp. nov., isolated from the junction between the ocean and a freshwater lake and emended description of the genus .

A novel marine Gram-stain-negative, non-motile, aerobic and rod-shaped bacterium, designated strain DSL-48, was isolated from tidal flat sediment sampled from the East China Sea and characterized phylogenetically and phenotypically. Bacterial optimal growth occurred at 35 °C (range, 4-37 °C), pH 6 (pH 5-10) and with 4 % (w/v) NaCl (0-7 %). The nearest phylogenetic neighbour was KCTC 52638 with 16S rRNA gene similarity of 97.

Marinomonas shanghaiensis sp. nov., isolated from the junction between an ocean and a freshwater lake.

A Gram-stain-negative, motile with single polar flagellum, rod-shaped bacterium, designated as strain DSL-35, was isolated from the location where the ocean and Dishui lake meet at Shanghai on the East China Sea and characterized phylogenetically and phenotypically. Optimal growth occurred at 35 °C (range, 4-40 °C), pH 8 pH 5-11) and with 3-4 % (w/v) NaCl (0-12 %). Phylogenetic analysis based on its 16S rRNA gene sequence showed that strain DSL-35 was related to members of the genus Marinomonas and shared the highest sequence identities with Marinomonasarctica 328 (98.

Comparison of Corticosteroid and Vincristine in Treating Kaposiform Hemangioendothelioma and Tufted Angioma: A Systematic Review and Meta-Analysis.

Objective:  To evaluate the outcome and safety of corticosteroids and vincristine (VCR) in the treatment of kaposiform hemangioendothelioma (KHE) and tufted angioma (TA).

Materials And Methods:  Clinical studies involving corticosteroids and VCR therapies in treating KHE/TA were identified by using PubMed, Cochrane Library, OVID, EBSCO, CNKI, VIP, and Wanfang databases from their establishment date to December 2017. Randomized controlled trials, case-control, or case series with more than five cases were included.

Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms and biliary atresia susceptibility in Chinese children.

Biliary atresia (BA) is a devastating liver disease of complex pathogenesis in neonates, characterized by an inflammatory and fibrosing obstruction of extrahepatic bile ducts. Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) is expressed on the surface of a subset of regulatory T cells (Treg) and down regulates the human immune response. To investigate the possible association between CTLA4 gene polymorphisms and BA susceptibility, we conducted a case-control study in the Chinese children.