W-band photonic-aided reconfigurable multichannel vector mm-wave transmission enabled by the digital subcarrier multiplexing technique.

As multimedia service demands rise, radio-over-fiber (RoF) systems necessitate a flexible wireless resource allocation in multi-user scenarios. Optical wavelength division multiplexing (WDM) can meet multi-user application scenarios but has the problems of high hardware cost and complexity. In this Letter, we propose a photonic-aided reconfigurable multichannel vector millimeter-wave (mm-wave) transmission scheme in the RoF system enabled by the digital subcarrier multiplexing (DSCM) technique.

W-band photonic-aided mm-wave ISAC system enabled by a shared OFDM signal waveform and a two-stage carrier frequency recovery algorithm.

Integrated sensing and communication (ISAC) systems will play a potential role in the upcoming six-generation (6G) networks. The reason is that ISAC systems can effectively solve the spectrum resource shortage problem and decrease the cost of deploying hardware equipment for simultaneously realizing communication and sensing. In this Letter, we successfully realize a W-band photonic-aided millimeter-wave (mm-wave) ISAC system enabled by a shared orthogonal-frequency-division-multiplexing (OFDM) signal waveform and two-stage carrier frequency recovery (CFR) algorithm.

Simultaneous wireless mm-wave transmission of both SC-modulated and OFDM-modulated high-order QAM signals enabled by bandpass delta-sigma modulation.

The application of dual vector millimeter-wave (mm-wave) signals in radio-over-fiber (RoF) systems represents a significant opportunity to enhance spectrum efficiency, transmission capacity, and access flexibility. In addition, facing the increasingly intricate application scenarios, the comprehensive exploitation of high-order quadrature-amplitude-modulation (QAM) signals with hybrid single-carrier (SC) and orthogonal-frequency-division-multiplexing (OFDM) modulation is also vital to rich systematic connotation. Based on bandpass delta-sigma modulation (BP-DSM) and heterodyne detection, we propose what we believe to be a novel scheme for the simultaneous wireless mm-wave transmission of both SC-modulated and OFDM-modulated high-order QAM signals.

Hybrid transmission of PS-GS4QAM and QPSK data in the form of a PS-16QAM mm-wave signal enabled by optical asymmetrical dual-SSB modulation.

The independent optical dual-single-sideband (dual-SSB) signal generation and detection can be achieved by an optical in-phase/quadrature (I/Q) modulator and one single photodiode (PD). The dual-SSB signal is able to carry two different information. After PD detection, the optical dual-SSB signal can be converted into an electrical millimeter-wave (mm-wave) signal.

Dual high-order QAM-modulated mm-wave signal transmission in the Q-band enabled by simple IM/DD architecture and bandpass delta-sigma modulation.

The intensity-modulation (IM)/direct-detection (DD) systems have been proven effective and low-cost due to their simple system architecture. However, the Mach-Zehnder modulator (MZM) of the IM/DD systems only reserves its driving signal intensity. Therefore, the IM/DD systems are generally unable to transmit vector signals and have a restricted spectrum efficiency and channel capacity.

Dual vector millimeter-wave signal generation based on optical carrier suppression modulation and direct detection with one photodetector.

We propose a novel, to the best of our knowledge, scheme for dual vector millimeter-wave (mm-wave) signal generation and transmission, based on optical carrier suppression (OCS) modulation, precoding, and direct detection by a single-ended photodiode (PD). At the transmitter side, two independent vector radio frequency (RF) signals with precoding, generated via digital signal processing (DSP), are used to drive an in-phase/quadrature (I/Q) modulator operating at the optical OCS modulation mode to simultaneously generate two independent frequency-doubling optical vector mm-wave signals, which can reduce the bandwidth requirement of transmitter's components and enhance spectral efficiency. With the aid of the single-ended PD and subsequent DSP at the receiver side, two independent frequency-doubling vector mm-wave signals can be separated and demodulated without data error.

Photonic-aided W-band dual-vector RF signal generation and detection enabled by bandpass delta-sigma modulation and heterodyne detection.

We propose a photonic-aided dual-vector radio-frequency (RF) signal generation and detection scheme enabled by bandpass delta-sigma modulation and heterodyne detection. With the aid of the bandpass delta-sigma modulation, our proposed scheme is transparent to the modulation format of the dual-vector RF signals and can support the generation, wireless transmission, and detection of both single-carrier (SC) and orthogonal-frequency-division-multiplexing (OFDM) vector RF signals with high-level quadrature-amplitude-modulation (QAM) modulation. With the aid of the heterodyne detection, our proposed scheme can support up to W-band (75-110 GHz) dual-vector RF signal generation and detection.

An injectable superior depot of Telratolimod inhibits post-surgical tumor recurrence and distant metastases.

The clinical success of Toll-like receptor (TLR) agonists is based on their capacity to efficiently mobilize both innate and adaptive immunity. However, rapid distribution of TLR agonists into the systemic circulation may result in systemic cytokine storms. Telratolimod (Tel) is a TLR 7/8 agonist whose structure has a hydrophobic long chain that helps to prolong its release.

ClickGene: an open cloud-based platform for big pan-cancer data genome-wide association study, visualization and exploration.

Tremendous amount of whole-genome sequencing data have been provided by large consortium projects such as TCGA (The Cancer Genome Atlas), COSMIC and so on, which creates incredible opportunities for functional gene research and cancer associated mechanism uncovering. While the existing web servers are valuable and widely used, many whole genome analysis functions urgently needed by experimental biologists are still not adequately addressed. A cloud-based platform, named CG (ClickGene), therefore, was developed for DIY analyzing of user's private in-house data or public genome data without any requirement of software installation or system configuration.

A quantitative method for assessing smoke associated molecular damage in lung cancers.

Background: While tobacco exposure is the cause of the vast majority of lung cancers, an important percentage arise in lifetime never smokers. Documenting the precise extent of tobacco induced molecular changes may be of importance. Also, the contribution of environmental tobacco smoke (ETS) is difficult to assess.

Genome-wide copy number variation pattern analysis and a classification signature for non-small cell lung cancer.

The accurate classification of non-small cell lung carcinoma (NSCLC) into lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) is essential for both clinical practice and lung cancer research. Although the standard WHO diagnosis of NSCLC on biopsy material is rapid and economic, more than 13% of NSCLC tumors in the USA are not further classified. The purpose of this study was to analyze the genome-wide pattern differences in copy number variations (CNVs) and to develop a CNV signature as an adjunct test for the routine histopathologic classification of NSCLCs.