A Clinical Assessment of a Magnetic Resonance Computer-Aided Diagnosis System in the Detection of Pathological Complete Response After Neoadjuvant Chemotherapy in Breast Cancer.

Purpose: This study aimed to assess the diagnostic performance and the added value to radiologists of different levels of a computer-aided diagnosis (CAD) system for the detection of pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in patients with breast cancer. Besides, to investigate whether tumor molecular typing is associated with the efficiency of diagnosis of the CAD systems.

Methods: 470 patients were identified with breast cancers who underwent NAC and post MR imaging between January 2016 and March 2019.

Ghrelin promotes neural differentiation of adipose tissue-derived mesenchymal stem cell via AKT/mTOR and β-catenin signaling pathways.

Adipose tissue-derived mesenchymal stem cells (ADSCs) are multipotent cells that can differentiate into various cell types. This study aimed to investigate the effect of ghrelin on the neural differentiation of rat ADSCs and underlying molecular mechanisms. Rat ADSCs were isolated and third-passage ADSCs were used in this study.

Diagnosis of lymph node metastasis on rectal cancer by PET-CT computer imaging combined with MRI technology.

To compare the diagnostic efficacy and clinical application value of Positron Emission Tomography-Computed Tomography (PET-CT) metabolic computer Imaging imaging and Magnetic Resonance Imaging (MRI) diffusion imaging technology for regional lymph node metastasis in rectal cancer, 41 patients with rectal cancer confirmed by colonoscopy were collected and underwent 3.0T pelvic MRI and PET-CT examination, respectively. PET-CT/MRI fusion software was used to fuse magnetic resonance images and PET-CT images and accurately locate the rectal cancer lesions and lymph nodes, and image-operation-pathology control method was used to identify the lymph nodes around the rectum.

Upregulated circular RNA circ_0016760 indicates unfavorable prognosis in NSCLC and promotes cell progression through miR-1287/GAGE1 axis.

Non-small cell lung cancer (NSCLC) is an aggressive malignancy with increasing worldwide incidence and is characterized by dismal prognosis due to its early recurrence and metastasis. Accumulating evidence documented that aberrantly expressed circular RNAs (circRNAs) are critically involved in tumorigenesis. In the current study, we focused on a novel circRNA, circ_0016760 in NSCLC.