Publications by authors named "Jiafeng Wang"

Background: The structural brain alterations for subjective cognitive decline (SCD) and mild cognitive impairment (MCI) are poorly defined. We sought to characterize grey matter volume (GMV) and cortical thickness associated with SCD and MCI among rural-dwelling older adults in China.

Methods: This population-based cross-sectional study included 1072 dementia-free participants from the brain MRI sub-study of MIND-China (2018-2020).

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Sepsis is defined as life-threatening organ injury induced by infection, with high incidence and mortality. Sleep disorder is prevalent in septic patients and approximately 50% of patients with sepsis may develop atypical sleep patterns, but many of them may have been underdiagnosed by physicians. Sleep disorders and sepsis exhibit a close bidirectional relationship, with each condition significantly influencing the other.

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  • The study investigates how cognitive reserve (CR) influences the physical function of older adults in rural China, focusing on participants aged 60 and up who are free from dementia.
  • Using data from 4,714 individuals, researchers created a composite CR score based on education, occupational complexity, and social engagement, finding that higher CR correlates with better physical performance outcomes.
  • The results show significant associations, particularly in those aged 75 and older, highlighting that greater CR leads to improved physical function, with no differences noted between sexes.
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  • The study investigates the relationship between the choroid plexus (CP) volume and cardiovascular risk factors as well as cerebral small vessel disease in older adults.
  • It involved 1263 participants, with a focus on how CP volume changes with age, sex, and diabetes, finding that men and diabetics had larger CP volumes.
  • The findings show that a larger CP is linked to increased white matter hyperintensities and enlarged perivascular spaces in certain brain regions, suggesting potential implications for neurodegenerative diseases.
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Plant tissue culture is extensively employed in plant functional genomics research and crop genetic improvement breeding. The callus induction ability is critical for utilizing Agrobacterium-mediated genetic transformation. In this study, we conducted a genome-wide association study (GWAS) utilizing 368 rice accessions to identify traits associated with callus induction rate (CIR), resulting in the identification of a total of 104 significant SNP loci.

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  • - The study compared different clinical tests for measuring stereopsis in 34 children with untreated unilateral amblyopia during treatment over 6 months.
  • - It found that Titmus and Frisby stereopsis tests consistently outperformed Random-dot stereopsis, but there were no significant differences between Titmus and Frisby.
  • - Although different measurement methods yield varying results, all methods showed similar effectiveness when tracking therapeutic improvement in amblyopia over time.
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  • The study investigates the analgesic effects of a single preoperative dose of dexamethasone on the effective concentration of remifentanil during a specific medical procedure (P-ESWL) in 60 patients.
  • Results indicated that the group receiving dexamethasone needed a significantly lower dose of remifentanil compared to the placebo group (2.02 ng/mL vs 2.65 ng/mL), suggesting enhanced pain relief with dexamethasone.
  • Both groups showed similar hemodynamic parameters, but the placebo group experienced notable decreases in blood pressure and heart rate, and fewer adverse events were reported in the dexamethasone group.
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Objectives: This study aimed to investigate the association between preoperative red blood cell distribution width (RDW) levels and liver injury (LI) after cardiac surgery, to highlight RDW's usefulness in the early identification and intervention for patients at high risk of LI.

Design: A retrospective observational study.

Setting: A university-affiliated teaching hospital and tertiary referral center.

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A general decline in the osteogenic differentiation capacity of human bone marrow mesenchymal stem cells (hBMSCs) in the elderly is a clinical consensus, with diverse opinions on the mechanisms. Many studies have demonstrated that metformin (MF) significantly protects against osteoporosis and reduces fracture risk. However, the exact mechanism of this effect remains unclear.

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  • Follicular thyroid carcinoma (FTC) and follicular thyroid adenoma (FTA) are difficult to differentiate due to similar clinical and ultrasound features, prompting a study to create a machine learning model to improve FTC diagnosis.
  • The study analyzed data from 780 patients across two hospitals to develop and validate various ML algorithms, focusing on ultrasound characteristics and clinical parameters to identify FTC more accurately.
  • Key factors influencing FTC diagnosis included age, echogenicity, certain antibody levels, and various ultrasound characteristics, which were assessed through multiple diagnostic performance metrics to find the best predictive model.
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The enmein-type diterpenoids are a class of anticancer -Kaurane diterpnoids that have received much attention in recent years. Herein, a novel 1,14-epoxy enmein-type diterpenoid , was reported in this project for the first time. A series of novel enmein-type diterpenoid derivatives were also synthesized and tested for anticancer activities.

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  • - A new electrochemical sensor has been developed for quick detection of foodborne pathogens like E. coli, S. aureus, and Salmonella typhimurium, which is important for food safety.
  • - This sensor uses a unique combination of aptamer and two-dimensional materials (TiCT and Zn-MOF) that enhances pathogen detection by capturing them and measuring changes in current.
  • - It can accurately quantify bacteria levels at very low concentrations (as low as 5-6 CFU/mL) and has proven effective in testing real food samples, making it very useful for ensuring food safety.
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Background: Sepsis, a complex and life-threatening disease, poses a significant global burden affecting over 48 million individuals. Recently, it has been reported that programmed death-ligand 1 (PD-L1) expressed on neutrophils is involved in both inflammatory organ dysfunction and immunoparalysis in sepsis. However, there is a dearth of strategies to specifically target PD-L1 in neutrophils in vivo .

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Background: This study aimed to assess the feasibility and safety of performing cholangiopancreatoscopy-assisted endoscopic mucosal resection (CA-EMR) for biliopancreatic intraductal lesions.

Methods: Special electrocautery snares and injection needles that can pass through the working channel of a single-operator cholangiopancreatoscope were developed. Between November 2023 and April 2024, we performed CA-EMR for two patients with gallbladder polyps, one patient with a neoplastic lesion in the common bile duct (CBD), and one patient with a neoplastic lesion in the main pancreatic duct.

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Background: Acute kidney injury (AKI) represents a significant complication following cardiac surgery, associated with increased morbidity and mortality rates. Despite its clinical importance, there is a lack of universally applicable and reliable methods for the early identification and diagnosis of AKI. This study aimed to examine the incidence of AKI after cardiac surgery, identify associated risk factors, and evaluate the prognosis of patients with AKI.

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Introduction: We sought to characterize cognitive profiles associated with enlarged perivascular spaces (EPVS) among Chinese older adults.

Methods: This population-based study included 1191 dementia-free participants (age ≥60 years) in the MIND-China MRI Substudy (2018-2020). We visually evaluated EPVS in basal ganglia (BG) and centrum semiovale (CSO), white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs), and cortical superficial siderosis.

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Ethnopharmacological Relevance: The Qinglongyi-Buguzhi herbal pair (QB) is one of commonly used herbal combinations for treating vitiligo in traditional Chinese medicine, consisting of the exocarp of the immature fruit of Juglans regia L. or Juglans mandshurica Maxim., and dried, mature fruit of Psoralea corylifolia L.

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Objectives: Cerebral small vessel disease (CSVD) visible on MRI can be asymptomatic. We sought to develop and validate a model for detecting CSVD in rural older adults.

Methods: This study included 1,192 participants in the MRI sub-study within the Multidomain Interventions to Delay Dementia and Disability in Rural China.

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Objectives: This study aimed to investigate the associations between changes in blood pressure (BP) and cerebral small vessel disease (CSVD).

Methods: This study included 401 participants in the magnetic resonance imaging (MRI) sub-study conducted between 2018 and 2020 as a part of the Multidomain Interventions to Delay Dementia and Disability in Rural China project. MRI markers of CSVD were assessed based on international criteria.

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Background: Salidroside (SAL) is the most effective component of , a traditional Chinese medicine. Cryptotanshinone (CT) is the main fat-soluble extract of , exhibiting considerable potential for application in osteogenesis. Herein, a polycaprolactone/gelatin nanofiber membrane loaded with CT and SAL (PSGC membrane) was successfully fabricated via coaxial electrospinning and characterized.

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  • Poly(ethylene glycol) (PEG) is commonly used for drug delivery but can lead to problems like rapid blood clearance and reduced effectiveness due to complement activation.
  • Researchers developed amphiphilic block copolymers, specifically PMSEA-PSN38 micelles, which combine hydrophilic sulfoxides with the hydrophobic drug SN38, showing improved blood circulation and intratumoral drug accumulation.
  • These PMSEA-PSN38 micelles also inhibit complement activation and reduce inflammation-related issues, promising better anti-cancer efficacy and lower side effects compared to traditional PEG-based formulations.
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Objective: We investigated the horizontal migration and transformation of nitrogen in soil with oxalic acid and inhibitors (e.g., nitrification inhibitors, DMPP, urease inhibitors, and NBPT) under different soil water contents to provide a basis for the efficient utilization of nitrogen fertilizer in agricultural production in karst areas.

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Amino acid epimerization, a process of converting -amino acids to -amino acids, will lead to modification in the protein structure and, subsequently, its biological function. This modification causes no change in protein m/z and may be overlooked during protein analysis. Aspartic Acid Epimerization (AAE) is faster than other amino acids and could be accelerated by free radicals and peroxides.

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