Publications by authors named "Jiafei Zhan"

Obesity is a major health hazard, suppressing the immune system and complicating inflammatory symptoms treatment. Traditional Chinese medicine emphasizes holistic principles and syndrome-based diagnosis/therapy. Its primary focus is on enhancing overall well-being, rather than solely aiming for weight loss.

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Age-associated impairment in antioxidant defense is an important cause of oxidative stress, and elderly individuals are usually associated with gut microbiota (GM) changes. Studies have suggested a potential relationship between the GM and changes in antioxidant defense in aging animals. Direct evidence regarding the impact of aging-associated shifts in GM on the antioxidant defense is lacking.

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Article Synopsis
  • The study focuses on adenylate kinases (EgADK1 and EgADK8) in Echinococcus granulosus, exploring their molecular characteristics and potential immunological roles.
  • Both enzymes were cloned and expressed, showing high sequence similarity, multiple phosphorylation sites, and B-cell epitopes, indicating their significance in ATP metabolism and parasite development.
  • Although EgADK1 and EgADK8 were found in various stages of the parasite, they are not effective as diagnostic antigens for cystic echinococcosis due to recognition by sera from other infected animals.
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The larval stage of sensu lato, resulting in cystic echinococcosis, a parasitic zoonosis, causes huge economic losses to the livestock industry and poses a threat to public health. Inhibitor of apoptosis proteins (IAPs) is a class of endogenous anti-apoptotic family, which plays a significant functional role in the regulation of organism's development. Herein, to explore potential functions of IAPs in , two members of IAPs from (Eg-IAP and Eg-BIRP) were cloned, expressed, and molecularly characterized.

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We report a sheep infected with Echinococcus canadensis G8 tapeworm in China in 2018. This pathogen was previously detected in moose, elk, muskox, and mule deer in Europe and North America; our findings suggest a wider host range and geographic distribution. Surveillance for the G8 tapeworm should be conducted in China.

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The larval stages of the tapeworm Echinococcus granulosus (Cestoda: Taeniidae) are the causative agent of cystic echinococcosis, one of the most important parasitic zoonoses worldwide. E. granulosus has a complete pathway for the tricarboxylic acid cycle (TCA), in which citrate synthase (CS) is the key enzyme.

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, the metacestode of , causes coenurosis, a disease severely affecting goat, sheep, cattle and yak farming and resulting in huge economic losses annually. Annexins bind calcium ions and play an important role in flatworm parasite development. To explore potential functions of annexins in , three homologous genes, namely, , and , were screened from the transcriptome dataset, amplified from cDNA and subjected to bioinformatics analysis.

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Cystic echinococcosis, a parasitic zoonosis that causes significant economic losses and poses a threat to public health, is caused by larvae of the tapeworm . Infection causes infertile cysts in intermediate hosts that cannot produce protoscoleces (PSCs) or complete the life cycle. Herein, we cloned, expressed, and characterised mitochondrial fission protein 1 () and programmed cell death protein 6 () from , and explored their functions related to infertile cysts.

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Taenia multiceps is a tapeworm that leads to the death of livestock, resulting in major economic losses worldwide. The adult stage of this parasite invades the small intestine of dogs and other canids. In the present study, we developed a direct PCR assay to detect T.

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