Repurposed Fenoprofen Targeting SaeR Attenuates Virulence in Implant-Associated Infections.

Implant-associated infections (IAIs) caused by can result in serious challenges after orthopedic surgery. Due to biofilm formation and antibiotic resistance, this refractory infection is highly prevalent, and finding drugs to attenuate bacterial virulence is becoming a rational alternative strategy. In , the SaeRS two-component system (TCS) plays a key role in the production of over 20 virulence factors and the pathogenesis of the bacterium.

A General Map of Transcriptional Expression of Virulence, Metabolism, and Biofilm Formation Adaptive Changes of When Exposed to Different Antimicrobials.

Biofilm formation of is the major cause of implant-associated infections (IAIs). Antimicrobial treatment is one of the most effective therapeutic options for infections. However, it can also lead to adaptive transcriptomic changes due to extreme selective pressure, which may increase the risk of antimicrobial resistance.

Synergistic Effects of Photobiomodulation Therapy with Combined Wavelength on Diabetic Wound Healing and .

The difficulty in chronic diabetic wound healing remains the focus of clinical research. Photobiomodulation therapy (PBMT) with different wavelengths could exert different effects on wound healing, but the effects of combined red and blue light (BL) remained unclear. Diabetic rat wound model and diabetic wounded endothelial cell model were established to observe possible effects of PBMT using combined wavelengths for wound healing.

Novel piston technique versus Ilizarov technique for the repair of bone defect after lower limb infection.

Background: We aimed to compare the effectiveness and complications of a novel piston technique versus the Ilizarov technique for the repair of bone defects after lower limb infection.

Patients And Methods: We retrospectively reviewed 41 patients who had been treated at our department for lower extremity bone defects following osteomyelitis. There were 38 men and three women with a mean age of 43.

Thermonucleases Contribute to Biofilm Formation in Implant-Associated Infections-A Redundant and Complementary Story.

Biofilms formed by are one of the predominant causes of implant-associated infections (IAIs). Previous studies have found that nucleases and modulate biofilm formation. In this study, we found low / expression and high biofilm-forming ability among IAI isolates.

High-purity magnesium pin enhances bone consolidation in distraction osteogenesis via regulating Ptch protein activating Hedgehog-alternative Wnt signaling.

Magnesium alloys are promising biomaterials for orthopedic implants because of their degradability, osteogenic effects, and biocompatibility. Magnesium has been proven to promote distraction osteogenesis. However, its mechanism of promoting distraction osteogenesis is not thoroughly studied.