Computational studies on the clusters of HONO•(HO)n(n = 1-7): structures and enthalpy of formation.

Context: Nitrous acid (HONO) is often associated with many air pollution events, such as the ozone hole, acid rain, and human health. Herein, we performed the theoretical studies on the structures and enthalpy of formation for the hydrated clusters HONO∙(HO)(n = 1-7). Two different isomers of HONO including cis-HONO and trans-HONO were studied.

Microniche geometry modulates the mechanical properties and calcium signaling of chondrocytes.

In articular cartilage, the function of chondrocytes is strongly related to their zone-specific microniche geometry defined by pericellular matrix. Microniche geometry is critical for regulating the phenotype and function of the chondrocyte in native cartilage and tissue engineering constructs. However the role of microniche geometry in the mechanical properties and calcium signaling of chondrocytes remains unknown.