Single-Cell Sequencing Reveals the Role of Radiation-Induced Stemness-Responsive Cancer Cells in the Development of Radioresistance.

Increased stemness of cancer cells exacerbates radioresistance, thereby greatly limiting the efficacy of radiotherapy. In order to study the changes in cancer cell stemness during radiotherapy, we established a radioresistance model of human non-small cell lung cancer A549 cells and obtained A549 radioresistant cells (A549-RR). We sampled the cells at different time points during the modeling process and investigated the heterogeneity of each group of cells using single-cell sequencing.

Doxorubicin-loaded PEGylated liposome modified with ANGPT2-specific peptide for integrative glioma-targeted imaging and therapy.

Liposomal nanocarriers are able to carry peptides for efficient and selective delivery of radioactive tracer and drugs into the tumors. Angiopoietin 2 (ANGPT2) is an excellent biomarker for precise diagnosis and therapy of glioma. The present study aimed to design ANGPT2-specific peptides to modify the surface of nanoliposomes containing doxorubicin (Dox) for integrative imaging and targeting therapy of glioma.

PEGylated Nanoliposomal Doxorubicin Conjugated with Specific TREM2 Peptides for Glioma-Targeting Therapy.

PEGylated liposomes can deliver anti-cancer drugs to brain tumors, and achieve enhanced permeability and retention effects. Triggering receptor expressed on myeloid cells 2 (TREM2) is an excellent biomarker for precise therapy of glioma. The present study is aimed at designing PEGylated nanoliposomal doxorubicin (PLD) conjugated with peptides targeting TREM2 for glioma-targeting therapy.

Polymeric nanoparticles in radiopharmaceutical delivery strategies.

The potential applications of polymer nanoparticles (NPs) in the biomedical field have been the subject of extensive research. Radiopharmaceuticals that combine radionuclides and drugs using polymer nanoparticles (NPs) as carriers can be externally labelled, internally labelled or interfacially labelled with radionuclides at different sites. Consequently, they can be employed as delivery agents for a range of diseases.

Exploration for cobalt/nitrogen-doped catalyst to creatinine degradation via peroxymonosulfate activation: toxicity evaluation, statistical modeling, and mechanisms study.

Developing multifunctional catalysts applied in diversiform modes via advanced oxidation processes (AOPs) is a promising and attractive approach for organic pollution degradation. Herein, a novel hollow bamboo-like structural cobalt/nitrogen-doped carbonized material (CoC/N) was employed as a catalyst for AOPs, in which CoC/N was prepared in situ through calcining a Co-based coordination polymer. When CoC/N was utilized as a peroxymonosulfate (PMS) activator, the catalyst stood out prominent activities for effective CA oxidation.

Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cells.

Background: Depletion of certain ribosomal proteins induces p53 activation, which is mediated mainly by ribosomal protein L5 (RPL5) and/or ribosomal protein L11 (RPL11). Therefore, RPL5 and RPL11 may link RPs and p53 activation. Thus, this study aimed to explore whether RPs interact with RPL11 and regulate p53 activation in lung adenocarcinoma (LUAD) cells.

2D MOFs-based Materials for the Application of Water Pollutants Removing: Fundamentals and Prospects.

Water quality can have serious impacts on human health. One crucial issue of water pollution seriously affects our safety due to the continually emerging of discovered anthropogenic pollutants. The water treatment technologies are persistent improvement to adapt such new contaminants, which accelerates the evolution of materials science to explore solving the problems.

Fe-Based Coordination Polymers as Battery-Type Electrodes in Semi-Solid-State Battery-Supercapacitor Hybrid Devices.

One two-dimensional Fe-based metal-organic framework (FeSC1) and one one-dimensional coordination polymer (FeSC2) have been solvothermally prepared through the reaction among FeSO·7HO, the tripodal ligand 4,4',4″--triazine-2,4,6-triyl-tribenzoate (HTATB), and flexible secondary building blocks p/m-bis((1H-imidazole-1-yl)methyl)benzene (bib). Given that their abundant interlayer spaces and different coordination modes, two compounds have been employed as battery-type electrodes to understand how void space and different coordination modes affect their performances in three-electrode electrochemical systems. Both materials exhibit outstanding but different electrochemical performances (including distinct capacities and charge-transfer abilities) under three-electrode configurations, where the charge storage for each electrode material is mainly dominated by the diffusion-controlled section ( ∝ ) through power-law equations.

Enhancing the Performance of a Battery-Supercapacitor Hybrid Energy Device Through Narrowing the Capacitance Difference Between Two Electrodes via the Utilization of 2D MOF-Nanosheet-Derived Ni@Nitrogen-Doped-Carbon Core-Shell Rings as Both Negative and Positive Electrodes.

Narrowing the capacitance gap between the positive and negative electrodes for the enhancement of the energy densities of battery-supercapacitor hybrid (BSH) devices is urgent and very important. Herein, a new strategy to synchronously improve the positive-negative system and reduce the capacitance discrepancies between two electrodes through the utilization of the same MOF-based precursors ([Ni(ATA)(HO)](HO)) has been proposed. Nickel/nitrogen codoped carbon (Ni@NC) materials, serving as positive electrodes, deliver battery-type behavior with the enhancement of capacities, which are even superior to those of pristine carbon-based materials with large surface areas.

From Ag Zr(IO ) to LaZr(IO ) F : A Case of Constructing Wide-band-gap Birefringent Materials through Chemical Cosubstitution.

Two mixed-metal zirconium iodates were prepared and studied as a case of chemical cosubstitution. The structure of Ag Zr(IO ) (P2 /c) features 0D [Zr(IO ) ] anion group and 1D [Ag(IO ) ] anionic chain, with the [Zr(IO ) ] anion groups interconnected by Ag ions into 3D network; LaZr(IO ) F (P2 /n) features 0D [Zr(IO ) F ] anion group and 2D [La(IO ) ] anionic layer, with the [Zr(IO ) F ] groups interlinked by La ions into 3D structure. Notably, LaZr(IO ) F is the first zirconium iodate fluoride reported.

Conjugate Polymer-clothed TiO@VO nanobelts and their enhanced visible light photocatalytic performance in water remediation.

An organic/inorganic core-shell nanobelt, TiO@VO-Polypyrrole (PPy) exhibiting high photocatalytic performance and water-stability was successfully prepared. The heterojunction between the TiO nanobelt and VO nanosheets improves both the ability to absorb visible light and the separation efficiency of the photogenerated carrier. When covered with the conjugated polymer PPy, the organic/inorganic nanocomposite absorbs throughout the whole visible light region and exhibits enhanced photocatalytic performance.

An Efficient Photocatalyst Based on Black TiO Nanoparticles and Porous Carbon with High Surface Area: Degradation of Antibiotics and Organic Pollutants in Water.

Porous carbon (PC) materials with high surface area can separate electron-hole pairs and adsorb organic pollutants more effectively. A series of nanocomposites were prepared by anchoring black TiO nanoparticles (BTN) onto PC through a calcination process. Chemical and structural features of samples were examined by X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, powder X-ray diffraction (P-XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses.

A self-penetrated three-dimensional zinc(II) coordination framework based on 4,4',4''-(1,3,5-triazine-2,4,6-triyl)tribenzoic acid and 1,3-bis[(imidazol-1-yl)methyl]benzene ligands: synthesis, structure and properties.

With the rapid development of metal-organic frameworks (MOFs), a variety of MOFs and their derivatives have been synthesized and reported in recent years. Commonly, multifunctional aromatic polycarboxylic acids and nitrogen-containing ligands are employed to construct MOFs with fascinating structures. 4,4',4''-(1,3,5-Triazine-2,4,6-triyl)tribenzoic acid (HTATB) and the bidentate nitrogen-containing ligand 1,3-bis[(imidazol-1-yl)methyl]benzene (bib) were selected to prepare a novel Zn-MOF under solvothermal conditions, namely poly[[tris{μ-1,3-bis[(imidazol-1-yl)methyl]benzene}bis[μ-4,4',4''-(1,3,5-triazine-2,4,6-triyl)tribenzoato]trizinc(II)] dimethylformamide disolvate trihydrate], {[Zn(CHNO)(CHN)]·2CHNO·3HO} (1).

Hyperbranched thiourea-grafted electrospun polyacrylonitrile fibers for efficient and selective gold recovery.

Research on the recovery of precious metals (including gold, Au), attracts attention of scientists worldwide. This paper reports synthesis of a novel fiber adsorbent consisting of hyperbranched thiourea-grafted electrospun polyacrylonitrile (HS-PAN) for Au(III) ion recovery. High-density functional groups of the hyperbranched structure allowed HS-PAN fibers to exhibit much higher affinity and selectivity towards Au(III) than towards Pt(IV), Cr(VI), Pb(II), Ni(II), Co(II), Fe(III), Mg(II), Cu(II) and Na(I).