[DNA microarray screening analysis in children with profound hearing impairment in Hubei province].

Objective: To investigate characteristics of molecular etiology of children with profound sensorineural hearing loss in Hubei province, and to provide reference for deafness treatment and genetic counseling.

Method: Three hundred and six children with profound sensorineural hearing loss in Hubei province were enrolled, their genomic DNA were extracted from peripheral blood and a deafness gene test chip was used to screen nine hot spot mutation in the GJB2, GJB3, SLC26A4, and mitochondria 12SrRNA gene. All patients with SLC26A4 gene mutation were given temporal bone CT scan.

[Electrophysiological findings for 106 cases with auditory neuropathy].

Objective: To analyses the clinical characteristics and electrophysiological finding of 106 patients with auditory neuropathy (AN). Investigate the differential curve type of pure tone audiogram and the abnormal ABR.

Methods: Review the history of patients, pure tone audiometry, middle ear acoustic reflexes, auditory brainstem response, distortion product otoacoustic emission and radiologic imaging studies of the brain of 106 patients with AN during December 2001 to May 2007 in retrospect.

[The study of 80 Hz auditory steady-state evoked potentials in patients with auditory neuropathy].

Objective: To investigate the character of 80 Hz auditory steady-state evoked potentials in auditory neuropathy (AN) patients and the correlation between it and ABR.

Method: The 80 Hz auditory steady-state evoked potentials and ABR to 95 dBnHL (1000 Hz) tone-pip stimuli were recorded from the scalp in patients with AN and normal subjects. The difference of the waveforms between AN ears and normal ears was compared.

[The ECochG in patients with auditory neuropathy].

Objective: The purpose of this study was to investigate the ECochG in subjects with auditory neuropathy (AN).

Method: The ECochG was recorded from ear canal electrode in patients with auditory neuropathy and normal subjects. The difference of their -SP amplitudes was compared.

[Integrated methods for assessing auditory nerve-auditory pathway integrity].

Objective: To evaluate the feasibility and value of integrated methods to assess auditory pathway integrity.

Method: Twenty-four cases of bilateral profoundly-deafened individuals who were considered as the candidates of cochlear implantation were included in this study. Auditory pathway integrity from these candidates of cochlear implantation were assessed with the integrated methods established by our team, which consist of 5 categories including 1.

[Benefit of bilateral cochlear implantation on congenital prelingually deafened Chinese-speaking children].

Objective: To evaluate the benefit of bilateral cochlear implants (BCIs) in prelingually deafened children on hearing rehabilitation as well as on speech and language development.

Method: Two cases of congenital profound deaf children, who received unilateral cochlear implantation (CI, MEDEL C40+) on the age of 2 and 7.5, respectively, were performed secondary CI in the contralateral ear on their age of 5 and 9.

[Audiological characteristics of auditory neuropathy].

Objective: To study the auditory electrophysiological characteristics of the auditory neuropathy.

Methods: Ten patients were diagnosed as auditory neuropathy. The history, pure tone audiometry, stapedial reflex, auditory brainstem response, electrocochleogram, distortion product otoacoustic emission and his contralateral suppression of white noise, middle latency response and slow cortical response were assessed.