Evaluation of protective immune response of live-attenuated candidate vaccines ΔcpxA and ΔcpxR against Vibrio alginolyticus in pearl gentian grouper.

The grouper farming industry was severely influenced by vibriosis. In this study, we developed two live-attenuated vaccine (LAV) candidates against Vibrio alginolyticus infection in pearl gentian groupers using cpxA or cpxR mutant strains of V. alginolyticus (ΔcpxA and ΔcpxR).