Identification and functional characterization of m1A-related genes in colorectal cancer: implications for prognosis, immune infiltration, and therapeutic strategies.

Introduction: Colorectal cancer (CRC), characterized by its complex genetic heterogeneity and varied responses to treatment, is a leading cause of cancer-related mortality worldwide. The role of N1-methyladenosine (m1A)-related genes in tumor biology remains underexplored. This study aimed to investigate the prognostic value of m1A-related genes in CRC, characterize their role in tumor molecular subtyping, and explore their influence on the tumor microenvironment (TME) and immune infiltration.

Biological Reinforced Concrete for Cartilage Repair With 3D Printing.

The development of biomimetic cartilage constructs (BCCs) with natural extracellular matrix (ECM) microenvironments and topological cues to accelerate the reconstruction of natural articular cartilage (NAC) after injury is challenging due to its complex structure, low cellular content, and less vascularity. Inspired by concrete rebar structure, a biomimetic cartilage named "biological reinforced concrete" is fabricated, with collagen fiber orientation transitioning from parallel to perpendicular, replicating the ECM microenvironments and complex construct of NAC. 3D-printed ultrafine fiber networks (UFNs) served as a degradable "biorebars", while a hybrid biohydrogel acted as "biocement".

Cation-Vacancy Engineering in Cobalt Selenide Boosts Electrocatalytic Upcycling of Polyester Thermoplastics at Industrial-Level Current Density.

The past decades have witnessed the increasing accumulation of plastics, posing a daunting environmental crisis. Among various solutions, converting plastics into value-added products presents a significant endeavor. Here, an electrocatalytic upcycling route that efficiently converts waste poly(butylene terephthalate) plastics into high-value succinic acid with high Faradaic efficiency of 94.

Remitting Seronegative Symmetrical Synovitis With Pitting Edema Syndrome With Fever as the First Clinical Manifestation:Report of One Case.

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a rare seronegative synovial inflammatory disease in which fever is a rare symptom.There are few case reports of RS3PE syndrome with fever as the first clinical manifestation in China.In this paper,we report a case of RS3PE syndrome with fever as the first symptom and diagnosed by systematic fever investigation.

Ultrasound guidance in the surgical removal of internal fixators after complete healing of limb fractures.

Purpose: The aim of this study was to determine whether ultrasound guidance can reduce the duration, blood loss volume and invasiveness of surgery for internal fixator removal.

Methods: The clinical data from 35 adults patients who underwent ultrasound-guided surgical removal of internal fixators after complete healing of limb fractures between June 2019 and April 2023 were retrospectively analysed and compared with those from 34 controls who underwent the procedure without ultrasound guidance. Data concerning the patients' demographic and clinical characteristics and surgical sites were collected.

Identification of PANoptosis-based signature for predicting the prognosis and immunotherapy response in AML.

Background: In recent years, the incidence of acute myeloid leukemia (AML) has increased rapidly with a suboptimal prognosis. In AML, cell death is independent of tumorigenesis, tumor invasion, and drug resistance. PANoptosis is a newly discovered form of cell death that combines pyroptosis, apoptosis, and necroptosis.

Nucleosome placement and polymer mechanics explain genomic contacts on 100kbp scales.

The 3d organization of the genome - in particular, which two regions of DNA are in contact with each other - plays a role in regulating gene expression. Several factors influence genome 3d organization. Nucleosomes (where ~ 100 basepairs of DNA wrap around histone proteins) also bend, twist and compactify chromosomal DNA, altering its polymer mechanics.

Oxidation of Polycyclic Aromatic Hydrocarbons (PAHs) Triggered by a Photochemical Synergistic Effect between High- and Low-Molecular-Weight PAHs.

Photooxidation of polycyclic aromatic hydrocarbons (PAHs), which are widely observed in atmospheric particulate matter (PM), largely determines their atmospheric fate. In the environment, PAHs are highly complex in chemical composition, and a great variety of PAHs tend to co-occur. Despite extensive investigation on the photochemical behavior of individual PAH molecules, the photochemical interaction among these coexisting PAHs is still not well understood.

Preliminarily exploring the intraoperative ultrasonography characteristics of patients with degenerative cervical myelopathy.

Background: How to quickly read and interpret intraoperative ultrasound (IOUS) images of patients with degenerative cervical myelopathy (DCM) to obtain meaningful information? Few studies have systematically explored this topic.

Purpose: To systematically and comprehensively explore the IOUS characteristics of patients with DCM.

Materials And Methods: This single-center study retrospectively included patients with DCM who underwent French-door laminoplasty (FDL) with IOUS guidance from October 2019 to March 2022.

FDAA: A feature distribution-aware transferable adversarial attack method.

In recent years, the research on transferable feature-level adversarial attack has become a hot spot due to attacking unknown deep neural networks successfully. But the following problems limit its transferability. Existing feature disruption methods often focus on computing feature weights precisely, while overlooking the noise influence of feature maps, which results in disturbing non-critical features.

Distinct Photochemistry of Odd-Carbon PAHs from the Even-Carbon Ones During the Photoaging and Analysis of Soot.

Polycyclic aromatic hydrocarbons (PAHs) are the primary organic carbons in soot. In addition to PAHs with even carbon numbers (PAH), substantial odd-carbon PAHs (PAH) have been widely observed in soot and ambient particles. Analyzing and understanding the photoaging of these compounds are essential for assessing their environmental effects.

Characteristics and mechanism of local scour reduction around spur dike using the collar in clear water.

To reduce the local scour around the spur dike, the U-shaped collar is proposed in this study. The influence of the collar's length, width, and porosity on the local scour reduction in clear water is studied by model tests and numerical simulations. Experimental studies show that the collar has a significant effect on reducing the local scour.

Faults locating of power distribution systems based on successive PSO-GA algorithm.

As the terminal of the power system, the distribution network is the main area where failures occur. In addition, with the integration of distributed generation, the traditional distribution network becomes more complex, rendering the conventional fault location algorithms based on a single power supply obsolete. Therefore, it is necessary to seek a new algorithm to locate the fault of the distributed power distribution network.

Quantitative evaluation of the impact of indoor relative humidity on deposition of aerosols generated during tooth grinding in a real-world clinical setting.

Objectives: Exposure to aerosol particles generated from tooth grinding has a negative impact on the health of dental personnel. The aim of this study was to quantitatively analyze the impact of indoor relative humidity (IRH) on the deposition of these suspended particles in a well-controlled dental environment.

Materials And Methods: In this study, a humidity control system was employed to effectively regulate and maintain indoor relative humidity (IRH).

Effect of a magnetic field on droplet freezing and frost formation on cold surfaces.

The effect of a magnetic field on condensed droplet freezing and frost formation was investigated using visualized experimental devices in this study. The size, shape, freezing time of droplets, and frost shape on the magnetic field considerably differ from those on the nonmagnetic surface. Moreover, the magnetic field could suppress droplet freezing and frost formation.

Nano-friction behavior and deformation study of hydroxyapatite in ultra-precision polishing process.

Context: In order to study the effect of ultra-precision machining on the surface quality of hydroxyapatite semiconductor materials as well as the material removal mechanism of hydroxyapatite, the mechanical polishing behaviors of hydroxyapatite at different polishing depths were studied by molecular dynamics method. The results show that the subsurface damage of hydroxyapatite increases with increasing polishing depth. The polishing temperature and the polishing force showed a positive correlation with the polishing depth, and the variation of the polishing force was related to the accumulation-release effect of the potential energy of hydroxyapatite material.

Study of aerosol dispersion and control in dental practice.

Objectives: In this study, we investigated the dispersion patterns of aerosols and droplets in dental clinics and developed a suction device to evaluate its effectiveness in reducing aerosols during dental procedures.

Materials And Methods: Firstly, the continuous images of oral aerosols and droplets were photographed with a high-speed camera, and the trajectories of these particles were recognized and processed by Image J to determine key parameters affecting particle dispersion: diffusion velocity, distance, and angle. Secondly, based on the parameter data, the flow field of aerosol particles around the oral cavity was simulated using computational fluid dynamics (CFD), and the flow field under adsorption conditions was simulated to demonstrate the aerodynamic characteristics and capture efficiencies of the single-channel and three-channel adsorption ports at different pressures.

Visualisation of Droplet Flow Induced by Ultrasonic Dental Cleaning.

Introduction: During dental treatment procedures ultrasonic scalers generate droplets containing microorganisms such as bacteria and viruses. Hence, it is necessary to study the dynamic properties of generated droplets in order to investigate the risks associated with the spread of infection. The aim of this study was to visualise the flow state of droplets and to evaluate the impact of droplets generated during the use of an ultrasonic scaler during an oral surgical procedure.

Numerical simulation and experimental verification of fatigue crack propagation in high-strength bolts based on fracture mechanics.

To investigate the fatigue crack propagation behavior of high-strength bolts for high-speed train brake discs, the fatigue crack propagation of high-strength bolts with initial defects under various load ratios was numerically simulated and experimentally verified based on fracture mechanics in this paper. Firstly, the fracture mechanics model of a three-dimensional hexahedral mesh with initial root defects was established using ABAQUS-FRANC3D interactive technology. Then the stress intensity factor (SIF) of the crack front was calculated by the stress superposition of the crack surface to simulate the coupling effect of preload and axial cyclic load.

Gelatin-Based Metamaterial Hydrogel Films with High Conformality for Ultra-Soft Tissue Monitoring.

Implantable hydrogel-based bioelectronics (IHB) can precisely monitor human health and diagnose diseases. However, achieving biodegradability, biocompatibility, and high conformality with soft tissues poses significant challenges for IHB. Gelatin is the most suitable candidate for IHB since it is a collagen hydrolysate and a substantial part of the extracellular matrix found naturally in most tissues.

Analysis of the response subsidence and grouting treatment in the goaf of multi-layer inclined coal seam.

Based on existing researches, field drillings and numerical simulations are carried out in this paper to analyze the problems of subsidence control in the goaf of multi-layer inclined coal seam. Midas/GTS NX is used to build a three-dimensional calculation model of the goaf. A new method of using borehole data to check simulation parameters is proposed.

Publication trends in nutrition research for sarcopenic obesity: A 20-year bibliometric analysis.

Background: We used bibliometric methods to evaluate publications on the role of nutrition in sarcopenic obesity and analyzed the current situation and developmental trends over the past 2 decades.

Methods: Publications from 2002 to 2022 related to the role of nutrition in sarcopenic obesity were extracted from the Web of Science Core Collection database. CiteSpace, VOSviewer, and the Bibliometrix R package were applied to build relevant network diagrams.

Energy-saving and product-oriented hydrogen peroxide electrosynthesis enabled by electrochemistry pairing and product engineering.

Hydrogen peroxide (HO) electrosynthesis through oxygen reduction reaction (ORR) is drawing worldwide attention, whereas suffering seriously from the sluggish oxygen evolution reaction (OER) and the difficult extraction of thermodynamically unstable HO. Herein, we present an electrosynthesis protocol involving coupling ORR-to-HO with waste polyethylene terephthalate (PET) upcycling and the first HO conversion strategy. Ni-Mn bimetal- and onion carbon-based catalysts are designed to catalyze ORR-to-HO and ethylene glycol electrooxidation with the Faradaic efficiency of 97.