Effect of amubarvimab-romlusevimab for treatment of severe COVID-19 in intensive care units: A retrospective cohort study.

Amubarvimab-romlusevimab is a commonly recommended antiviral treatment in China for adult patients with mild or moderate SARS-CoV-2 infections, especially for patients with a high risk factor for progression to severe COVID-19. However, its exact efficacy in patients with severe Covid-19 is not yet known.This is a single-center retrospective cohort study, in which we collected the general data, laboratory tests, radiological characteristics, viral conversion status, and prognosis of the disease from patients with COVID-19 hospitalized, from December 2022 to March 2023 in the Department of Critical Care Medicine.

Customized Lanthanide Nanobiohybrids for Noninvasive Precise Phototheranostics of Pulmonary Biofilm Infection.

A noninvasive strategy for diagnosis and precise treatment of bacterial biofilm infections is highly anticipated but still a great challenge. Currently, no biofilm-targeted theranostic agent is available. Herein, we fabricated intelligent theranostic alginate lyase (Aly)-NaNdF nanohybrids with a 220 nm sunflower-like structure (NaNdF@DMS-Aly) through an enrichment-encapsulating strategy, which exhibited excellent photothermal conversion efficiency and the second near-infrared (NIR-II) luminescence.

Optimizing cell voltage dependence on size of carbon nanotube-based electrodes in Na-ion and K-ion batteries.

Sodium-ion batteries (NIBs) and potassium-ion batteries (KIBs) are gaining extensive attention as promising alternatives to lithium-ion batteries owing to their superior energy density and cost-effectiveness. However, the larger ionic radius of Na and K ions in comparison to Li ions poses a challenge in designing anode materials characterized by enduring structures and elevated voltage to facilitate the efficacy of high-performance NIBs and KIBs. Carbon nanomaterials, particularly carbon nanotubes (CNTs), have emerged as a potential candidate in anode materials.

Using a cyclocarbon additive as a cyclone separator to achieve fast lithiation and delithiation without dendrite growth in lithium-ion batteries.

Carbon materials are widely used for reversible lithium uptake in the anode of lithium-ion batteries. Nevertheless, the challenge of uncontrollable dendrite deposition during fast charge-discharge cycles remains a grand hurdle. Various strategies have been explored to prevent detrimental heterogeneous dendrite metal deposits, such as interface engineering and electrolyte modification, but they often compromise the reverse diffusion freedom of Li ions during discharging and are incompatible with the most mainstream use of graphite as an anode material.

Autophagic degradation of MVBs in LSECs promotes Aldosterone induced-HSCs activation.

Background And Aims: The important role of extracellular vesicles (EVs) in liver fibrosis has been confirmed. However, EVs derived from liver sinusoidal endothelial cells (LSECs) in the activation of hepatic stellate cells (HSCs) and liver fibrosis is still unclear. Our previous work demonstrated that Aldosterone (Aldo) may have the potential to regulate EVs from LSECs via autophagy pathway.

Caveolin-1 depletion attenuates hepatic fibrosis via promoting SQSTM1-mediated PFKL degradation in HSCs.

The key glycolytic enzyme phosphofructokinase (PFK) is responsible for maintaining glycolytic stability and an important energy source for activating hepatic stellate cells (HSCs). However, its regulation in activated HSCs remains unclear. Caveolin-1 (Cav1), a major constituent of caveolae, has emerged as a key target for triggering glycolysis.

Sacubitril/valsartan alleviates sepsis-induced acute lung injury via inhibiting GSDMD-dependent macrophage pyroptosis in mice.

Sepsis-induced acute lung injury (ALI) is a life-threatening disorder with intricate pathogenesis. Macrophage pyroptosis reportedly plays a vital role in ALI. Although it has been established that angiotensin receptor blockers (ARBs) can reduce sepsis-induced organ injury, the efficacy of sacubitril/valsartan (SV) for sepsis has been largely understudied.

Multistate Circularly Polarized Luminescence Switching through Stimuli-Induced Co-Conformation Regulations of Pyrene-Functionalized Topologically Chiral [2]Catenane.

Aiming at the construction of novel circularly polarized luminescence (CPL) switches with multiple switchable emission states and high dissymmetry factors (g ), topologically chiral [2]catenanes were employed as the key platform to construct a novel multistate CPL switching system. Taking advantage of the precise co-conformation regulations of the resultant pyrene-functionalized [2]catenanes under different external stimuli, reversible transformations between three emission states with different CPL performances, i.e.

Two-photon fluorescence imaging and ratiometric quantification of mitochondrial monoamine oxidase-A in neurons.

Herein, we designed and developed a single two-photon ratiometric fluorescence probe (TMF2P) for selective and accurate determination of mitochondrial MAO-A in live neurons. It was discovered that the increases in MAO-A levels under oxidative stress resulted in an elevated influx of Ca flow into mitochondria through the transient receptor potential melastatin 2 (TRPM2) channels.

Enhanced self-activated far-red photoluminescence from SrLiSbO phosphors by Gd doping for plant growth.

SrLiSbO phosphors were prepared by high temperature solid state reaction method. The crystal phase, morphology and optical properties were characterized by X-ray powder diffraction spectroscopy, scanning electronic microscope, absorption and photoluminescence (PL) spectra. The XRD Rietveld refinement was performed to obtain the detailed crystal structure of SrLiSbO.

Zeolitic imidazolate framework-8 reinforced hollow-fiber liquid-phase microextraction of free urinary biomarkers of whole grain intake followed by CE analysis.

The whole grain intake is closely associated with human health. In this work, three-phase dynamic hollow-fiber liquid-phase microextraction reinforced with 0.10 mg/mL 30 nm zeolitic imidazolate framework-8 nanoparticles was introduced for purification and enrichment of free urinary metabolite biomarkers of whole grain intake.