Enhanced NH-SCR activity of Cu-SAPO-34 by regulating Si distribution an interzeolite conversion strategy.

An interzeolite conversion (IZC) method was developed for the rapid synthesis of Cu-SAPO-34 from SAPO-37, achieving isolated Si distribution and optimized Cu states. The resulting Cu-SAPO-34 exhibited exceptional NH-SCR performance, with over 90% NO conversion from 200-600 °C due to proper acidity and Cu status generated from the isolated Si.

Unraveling the relationship between obstructive sleep apnea and osteoarthritis: A multivariate mendelian randomization highlighting the role of BMI as a confounding factor.

Background: Osteoarthritis (OA) and obstructive sleep apnea (OSA) are prevalent chronic conditions with emerging evidence suggesting a potential link. However, the causality of this association remains unclear, possibly influenced by confounders like high body mass index (BMI). This study aimed to explore causal relationships between OA and OSA using Mendelian randomization (MR).

Comparative analysis of cancer statistics in China and the United States in 2024.

Background: Cancer patterns in China are becoming similar to those in the United States (US). Comparing the recent cancer profiles, trends, and determinants in China and the US can provide useful reference data.

Methods: This study used open-source data.

Engineering gene-activated bioprinted scaffolds for enhancing articular cartilage repair.

Untreated articular cartilage injuries often result in severe chronic pain and dyskinesia. Current repair strategies have limitations in effectively promoting articular cartilage repair, underscoring the need for innovative therapeutic approaches. A gene-activated matrix (GAM) is a promising and comprehensive therapeutic strategy that integrates tissue-engineered scaffold-guided gene therapy to promote long-term articular cartilage repair by enhancing gene retention, reducing gene loss, and regulating gene release.

[Retracted] DNA methyltransferase 3b silencing affects locus‑specific DNA methylation and inhibits proliferation, migration and invasion in human hepatocellular carcinoma SMMC‑7721 and BEL‑7402 cells.

[This retracts the article DOI: 10.3892/ol.2015.

Revealing potential mechanisms of native and non-native snail coexistence through fecal microbiomes and dietary compositions.

Understanding how animals coexist within an ecosystem is essential for the conservation of biodiversity. In China, large populations of a non-native snail Rumina decollata (a highly invasive species reported by various other countries) coexist with two native snail species (Acusta ravida and Euphaedusa aculus). However, the potential mechanisms that facilitate this non-native and native snail coexistence remain uncertain.

[Effects of Different Nitrogen Application Measures on NO Emissions in Wheat-maize Rotation System].

To investigate the response of NO emissions from farmland soil to different nitrogen application measures and the factors affecting it in the wheat and jade rotation system in North China, we analyzed the results of the one-time application of fertilizer in the following six treatments： without fertilization （CK）, conventional nitrogen application （urea, one instance of follow-up fertilization, U1）, optimized nitrogen application （20% nitrogen reduction, one instance of follow-up fertilization, U2）, one-time fertilization of controlled-release doped fertilizers （50% urea + controlled-release urea 50%, nitrogen reduction 20%, SRU1）, controlled-release fertilizer one-time fertilization （nitrogen reduction 20%, SRU2）, and inhibitor-type controlled-release fertilizer one-time fertilization （nitrogen reduction 20%, ISRU）, and the differences in NO emission fluxes and soil physicochemical properties were determined. The results showed that soil NO emission fluxes were dynamic during the wheat and jade crop rotation, and the NO emission peaks of the CK, U1, and U2 treatments appeared in the corn season at 4-7d of basal fertilizer and 6-10d of fertilizer, and out of the wheat season its emission peaks appeared in the basal fertilizer at 4-8 d and 6-9 d of fertilizer. The emission peaks of SRU1, SRU2, and ISRU appeared in the basal fertilizer at 10-21 d, 12-20 d, and 12-20 d of fertilizer, respectively, in the corn season and the wheat season.

Reconstructing Molecular Networks by Causal Diffusion Do-Calculus Analysis with Deep Learning.

Quantifying molecular regulations between genes/molecules causally from observed data is crucial for elucidating the molecular mechanisms underlying biological processes at the network level. Presently, most methods for inferring gene regulatory and biological networks rely on association studies or observational causal-analysis approaches. This study introduces a novel approach that combines intervention operations and diffusion models within a do-calculus framework by deep learning, i.

Enzyme-responsive microgel with controlled drug release, lubrication and adhesion capability for osteoarthritis attenuation.

The treatment of osteoarthritis (OA) remains challenging due to the narrow therapeutic window and rapid clearance of therapeutic agents, even with intra-articular administration, resulting in a low treatment index. Recent advancements in local drug delivery systems have yet to overcome the issues of uncontrolled burst release and short retention time, leading to suboptimal OA treatment outcome. Herein, we developed a methacrylate-crosslinking hyaluronic acid (HA) microgel (abbreviated as CXB-HA-CBP) that covalently conjugates the anti-inflammatory drug celecoxib (CXB) via a metalloproteinase-2 (MMP-2)-responsive peptide linker (GGPLGLAGGC) and a collagen II binding peptide (WYRGRLC).

Tuning Na Occupation and Annealing Temperature on Na Diffusion Pathways in P2-Type NaNiMnO for Sodium-Ion Batteries by Ab Initio Calculations.

The NaNiMnO cathode material draws ongoing interest owing to its considerable specific capacity along with its elevated average operating voltage. However, its application is limited by weak rate performance and quick capacity fading. In this study, a series of NaNiMnO ( = 0.

165 MHz highly stable femtosecond Er:ZBLAN fiber laser operating at 2.8 µm.

Three-micrometer mid-infrared (MIR) femtosecond pulse sources with a high repetition rate (HRR) have potential applications in a number of fields such as biological imaging, optical frequency combs, and gas detection. In this paper, by optimizing the fiber length and the cavity structure, we demonstrated a highly stable, self-starting mode-locked fluoride fiber laser (MLFFL) with a fundamental repetition rate of ∼165 MHz and a signal-to-noise ratio (SNR) of 90 dB. As far as we know, this stands as the highest fundamental repetition rate ever acquired directly from an ultrafast MLFFL in the >2.

StuGPTViz: A Visual Analytics Approach to Understand Student-ChatGPT Interactions.

The integration of Large Language Models (LLMs), especially ChatGPT, into education is poised to revolutionize students' learning experiences by introducing innovative conversational learning methodologies. To empower students to fully leverage the capabilities of ChatGPT in educational scenarios, understanding students' interaction patterns with ChatGPT is crucial for instructors. However, this endeavor is challenging due to the absence of datasets focused on student-ChatGPT conversations and the complexities in identifying and analyzing the evolutional interaction patterns within conversations.

Development of aptamer-based lateral flow devices for rapid detection of SARS-CoV-2 S protein and uncertainty assessment.

The outbreak and spread of COVID-19 have highlighted the urgent need for early diagnosis of SARS-CoV-2. Nucleic acid testing as an authoritative tool, is cumbersome, time-consuming, and easy to cross-infect, while the available antibody self-testing kits are deficient in sensitivity and stability. In this study, we developed competitive aptamer-based lateral flow devices (Apt-LFDs) for the quantitative detection of SARS-CoV-2 spike (S) protein.

Intensive investigation of the synergistic effects between electrocatalysis and peroxymonosulfate activation for efficient organic elimination.

Hybrid systems combined eletrocatalysis and Fenton-like process attract a lot of attention due their outstanding performance and unique mechanism. Here, we proposed an efficient, cost-effective, and versatile electrochemical activation (ECA) system for efficient water purification, and intensively studied the synergistic effects between electrocatalysis and peroxymonosulfate (PMS)-based advanced oxidation. The ECA system achieved complete removal of 20 ppm tetracycline hydrochloride (TCH) in 15 min, with a rate constant of 0.

Therapeutic potential of arginine deprivation therapy for gliomas: a systematic review of the existing literature.

Background: Arginine deprivation therapy (ADT) hinders glioma cells' access to nutrients by reducing peripheral blood arginine, showing great efficacy in various studies, which suggests it as a potentially promising treatment for glioma. The aim of this systematic review was to explore the mechanism of ADT for gliomas, the therapeutic effect based on existing research, and possible combination therapies.

Methods: We performed a systematic literature review of PubMed, ScienceDirect and Web of Science databases according to PRISMA guidelines, searching for articles on the efficacy of ADT in glioma.

Global epidemiology of liver cancer 2022: An emphasis on geographic disparities.

Background: Liver cancer remains the sixth most commonly diagnosed cancer and the third leading cause of cancer-related deaths worldwide, causing a heavy burden globally. An updated assessment of the global epidemiology of the liver cancer burden that addresses geographical disparities is necessary to better understand and promote healthcare delivery.

Methods: Data were extracted from the GLOBOCAN 2022 database, including the number, crude, and age-standardized rates of incidence and mortality at the global, country, continent, and human development index (HDI) regional levels.

Identification of Autophagy-Related Genes in Patients with Acute Spinal Cord Injury and Analysis of Potential Therapeutic Targets.

Autophagy has been implicated in the pathogenesis and progression of spinal cord injury (SCI); however, its specific mechanisms remain unclear. This study is aimed at identifying potential molecular biomarkers related to autophagy in SCI through bioinformatics analysis and exploring potential therapeutic targets. The mRNA expression profile dataset GSE151371 was obtained from the GEO database, and R software was used to screen for differentially expressed autophagy-related genes (DE-ARGs) in SCI.

The impact of lenses on the seepage failure of tailings dam.

The presence of lenses such as tailings slurry, frozen soil, and saturated zones disrupts the continuity of tailings dams and their normal seepage patterns, elevating the seepage line of the dam body and significantly impacting local stability. This study, to investigate how lenses affect the stability and failure mechanisms of tailings dams, employs numerical simulation and physical models and constructs a model of the tailings dam, incorporating tailings clay lens and void lens, to investigate variations in hydraulic gradients, seepage velocities, seepage flow, pore water pressure, and the patterns of seepage failure. This research reveals that the tailings clay lens within the dam body increases the hydraulic gradient in its vicinity due to its low permeability and raises the phreatic line.

Global, regional, and national burden of early-onset gastric cancer.

Objective: The burden of gastric cancer (GC) across different age groups needs updating. We determined the GC global, regional, and national burden profiles and changes in incidence for 3 sequential 5-year intervals from 2003 to 2017.

Methods: The latest incidence and mortality estimates of GC from 185 countries and regions were extracted from the GLOBOCAN 2022 database.