Unraveling Paradoxical Effects of Large Current Density on Zn Deposition.

Aqueous zinc-based batteries (ZBs) have been widely investigated owing to their intrinsic safety, low cost, and simple assembly. However, the actual behavior of Zn deposition under large current density is still a severe issue associated with obscure mechanism interpretation of ZBs under high loading. Here, differing from the conventional understanding that short circuit is induced by dendrite penetrating under large current density (10-100 mA cm), the separator permeation effect is unraveled to illustrate the paradox between smooth deposition and short lifespan.

Exploring and Interacting with the Set of Good Sparse Generalized Additive Models.

In real applications, interaction between machine learning models and domain experts is critical; however, the classical machine learning paradigm that usually produces only a single model does not facilitate such interaction. Approximating and exploring the Rashomon set, i.e.

OKRidge: Scalable Optimal k-Sparse Ridge Regression.

We consider an important problem in scientific discovery, namely identifying sparse governing equations for nonlinear dynamical systems. This involves solving sparse ridge regression problems to provable optimality in order to determine which terms drive the underlying dynamics. We propose a fast algorithm, OKRidge, for sparse ridge regression, using a novel lower bound calculation involving, first, a saddle point formulation, and from there, either solving (i) a linear system or (ii) using an ADMM-based approach, where the proximal operators can be efficiently evaluated by solving another linear system and an isotonic regression problem.

Value of the Air Bronchogram Sign and Other Computed Tomography Findings in the Early Diagnosis of Lung Adenocarcinoma.

Objectives: The present study aims to explore the application value of the air bronchogram (AB) sign and other computed tomography (CT) signs in the early diagnosis of lung adenocarcinoma (LUAD).

Method: The pathological information and CT images of 130 patients diagnosed with N 0 and M 0 solitary pulmonary nodules (diameter ≤3 cm) and treated with surgical resection in our hospital between June 2021 and June 2022 were analyzed.

Results: The patients were divided into the benign pulmonary nodule (BPN) group (14 cases), the AIS group (30 cases), the MIA group (10 cases), and the IAC group (76 cases).

Collagen-Based Organohydrogel Strain Sensor with Self-Healing and Adhesive Properties for Detecting Human Motion.

Conductive hydrogels are ideal for flexible sensors, but it is still a challenge to produce such hydrogels with combined toughness, self-adhesion, self-healing, anti-freezing, moisturizing, and biocompatibility properties. Herein, inspired by natural skin, a highly stretchable, strain-sensitive, and multi-environmental stable collagen-based conductive organohydrogel was constructed by using collagen (Col), acrylic acid, dialdehyde carboxymethyl cellulose, 1,3-propylene glycol, and AlCl. The resulting organohydrogel exhibited excellent tensile (strain >800%), repeatable adhesion (>10 times), self-healing [self-healing efficiency (SHE) ≈ 100%], anti-freezing (-60 °C), moisturizing (>20 d), and biocompatible properties.

Fast Sparse Classification for Generalized Linear and Additive Models.

We present fast classification techniques for sparse generalized linear and additive models. These techniques can handle thousands of features and thousands of observations in minutes, even in the presence of many highly correlated features. For fast sparse logistic regression, our computational speed-up over other best-subset search techniques owes to linear and quadratic surrogate cuts for the logistic loss that allow us to efficiently screen features for elimination, as well as use of a priority queue that favors a more uniform exploration of features.

Highly Sensitive and Robust Polysaccharide-Based Composite Hydrogel Sensor Integrated with Underwater Repeatable Self-Adhesion and Rapid Self-Healing for Human Motion Detection.

Tough, biocompatible, and conductive hydrogel-based strain sensors are attractive in the fields of human motion detection and wearable electronics, whereas it is still a great challenge to simultaneously integrate underwater adhesion and self-healing properties into one hydrogel sensor. Here, a highly stretchable, sensitive, and multifunctional polysaccharide-based dual-network hydrogel sensor was constructed using dialdehyde carboxymethyl cellulose (DCMC), chitosan (CS), poly(acrylic acid) (PAA), and aluminum ions (Al). The obtained DCMC/CS/PAA (DCP) composite hydrogels exhibit robust mechanical strength and good adhesive and self-healing properties, due to the reversible dynamic chemical bonds and physical interactions such as Schiff base bonds and metal coordination.

Dihydroisatropolone C from and Its Implication in Tropolone-Ring Construction for Isatropolone Biosynthesis.

Isatropolones/isarubrolones are actinomycete secondary metabolites featuring a tropolone-ring in their structures. From the isatropolone/isarubrolone producer sp. CPCC 204095, 7,12-dihydroisatropolone C (HITC) is discovered and identified as a mixture of two interchangeable diastereomers differing in the C-6 configuration.

Clinicopathological characteristics, survival outcomes and prognostic factors in pleomorphic carcinoma: a SEER population-based study.

Background: Pulmonary pleomorphic carcinoma (PPC) is a rare tumor, and it usually has an aggressive clinical course and poor prognosis. We aim to analyze the clinicopathological features, management and prognostic factors of pulmonary pleomorphic carcinoma.

Patients And Methods: Using the surveillance, epidemiology, and end results (SEER) database, we identified 461 patients of pulmonary pleomorphic carcinoma from 2004 to 2014 including clinicopathological characteristics, treatment modalities and outcome data.

BEZ235 reduction of cisplatin resistance on wild-type EGFR non-small cell lung cancer cells.

Cisplatin, as a first-line chemotherapy drug for advanced wild-type epidermal growth factor receptor (wtEGFR) non-small cell lung cancer (NSCLC), often loses effectiveness because of acquired drug resistance. We found that ataxia-telangiectasia mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) of DNA repair kinases and signal transduction molecules, protein kinase B (AKT)/target mammalian target of rapamycin (mTOR), were significantly phosphorylated in cisplatin-resistant wtEGFR NSCLC cell lines (H358R and A549R) than in their parental cells. Also, BEZ235 (dual phosphatidylinositol-3-kinase (PI3K)/mTOR inhibitor) significantly decreased the phosphorylation levels of these kinases/proteins, as detected by Western blot analysis.

Representing Graphs via Gromov-Wasserstein Factorization.

Graph representation is a challenging and significant problem for many real-world applications. In this work, we propose a novel paradigm called "Gromov-Wasserstein Factorization" (GWF) to learn graph representations in a flexible and interpretable way. Given a set of graphs, whose correspondence between nodes is unknown and whose sizes can be different, our GWF model reconstructs each graph by a weighted combination of some "graph factors" under a pseudo-metric called Gromov-Wasserstein (GW) discrepancy.

Cytochrome P450 Monooxygenase for Catalyzing C-42 Hydroxylation of the Glycine-Derived Fragment in Hangtaimycin Biosynthesis.

A hybrid -AT PKS/NRPS gene cluster was identified with defined boundaries for hangtaimycin biosynthesis in CPCC200148. Deoxyhangtaimycin, a new derivative of hangtaimycin, was identified from the gene knockout mutant. In vitro biochemical assays demonstrated that the cytochrome P450 monooxygenase Htm11 was responsible for the stereoselective hydroxylation of deoxyhangtaimycin to hangtaimycin.

Clinical and drug resistance characteristics of infections in 76 patients.

Objectives: To investigate the clinical and drug resistance characteristics of infections in the Huainan region of Anhui and provide a reference for the clinical selection of antimicrobial agents.

Methods: This single-center retrospective analysis included 76 patients with infection in Huainan during the period from October 2018 to March 2020. The hospital department in which the patients were treated and the drug susceptibility characteristics of the isolates were recorded.

Gefitinib sensitization of cisplatin-resistant wild-type EGFR non-small cell lung cancer cells.

Purpose: The usual first-line strategy of wild-type EGFR (wtEGFR) non-small cell lung cancer (NSCLC) remains cisplatin-based chemotherapy. However, cisplatin often loses effectiveness because most tumors acquire drug resistance over time. As EGFR is the most important pro-survival/proliferation signal receptor in NSCLC cells, we aimed at investigating whether cisplatin resistance is related to EGFR activation and further evaluating the combined effects of cisplatin/gefitinib (EGFR-tyrosine kinase inhibitor, EGFR-TKI) on cisplatin-resistant wtEGFR NSCLC cells.

BEZ235 increases sorafenib inhibition of hepatocellular carcinoma cells by suppressing the PI3K/AKT/mTOR pathway.

Background: Sorafenib is an oral multi-kinase inhibitor that inhibits hepatocellular carcinoma (HCC) via the Ras/Raf/MAPK pathway. However, sorafenib loses effectiveness because most tumors acquire drug resistance over time. As the PI3K/AKT/mTOR signaling pathway is also activated abnormally in HCC, we evaluated the effect of sorafenib, in combination with a dual PI3K/mTOR inhibitor, BEZ235, on HCC cell proliferation and survival in vitro.

Multiplexed chemiluminescence determination of three acute myocardial infarction biomarkers based on microfluidic paper-based immunodevice dual amplified by multifunctionalized gold nanoparticles.

Acute myocardial infarction (AMI) causes significant mortality and morbidity. The determination of multiple AMI biomarkers is very important for the timely diagnosis of AMI. In this work, simultaneous determination of three AMI biomarkers were achieved by virtue of a three-dimensional (3D) microfluidic paper-analytical device (μPAD) with temporally resolved chemiluminescence (CL) emissions for the first time.

Three-dimensional microfluidic paper-based device for multiplexed colorimetric detection of six metal ions combined with use of a smartphone.

A simple double-layered three-dimensional (3D) microfluidic paper-based analytical device (μPAD) was designed for the simultaneous determination of six metal ions-Fe(III), Ni(II), Cr(VI), Cu(II), Al(III), and Zn(II)-for the first time. The 3D μPAD was composed of two paper layers: a top pretreatment layer and a bottom colorimetric detection layer. The sample solution added to the central sample reservoir of the 3D μPAD could be automatically divided into eight flow pathways and be automatically pretreated while flowing through the pretreatment zones located in the microfluidic channels, and automatically carried out the chromogenic reactions after reaching the detection zones.

High-resolution temporally resolved chemiluminescence based on double-layered 3D microfluidic paper-based device for multiplexed analysis.

In this work, a double-layered three-dimensional (3D) microfluidic paper-based analytical device (μPAD) with high resolution temporally resolved chemiluminescence (CL) emissions were designed for multiplexed CL analysis. The temporally resolved CL emissions were obtained by virtue of the 3D branched microfluidic channel design, which create time delays for luminol transported from one detection zone to another. The peak intensity and peak shape of the temporally resolved CL emissions were quite stable and base-line separated with resolution as high as 21.

An ultrasensitive label-free colorimetric assay for glutathione based on Ag regulated autocatalytic oxidation of o-phenylenediamine.

The discriminative determination of glutathione (GSH) over cysteine (Cys) and homocysteine (Hcy) is still challenging in bioassays due to their similar functional groups. Herein, a novel, simple, rapid, sensitive and cost-effective label-free colorimetric method for the selective determination of GSH over Cys and Hcy was proposed. In this assay, firstly, o-phenylenediamine (OPD) could be oxidized by silver ions (Ag) to produce silver nanoparticles (AgNPs) and pale yellow colored 2,3-diaminophenazine (shorted as OPDox) with absorbance peak center at 429 nm.

Luminol, horseradish peroxidase, and glucose oxidase ternary functionalized graphene oxide for ultrasensitive glucose sensing.

Luminol, horseradish peroxidase (HRP), and glucose oxidase (GOx) ternary functionalized graphene oxide (HRP/GOx-luminol-GO) with excellent chemiluminescence (CL) activity and specific enzymatic property was prepared via a simple and general strategy for the first time. In this approach, luminol functionalized GO (luminol-GO) was prepared by gently stirring GO with luminol. Then HRP and GOx were further co-immobilized onto the surface of luminol-GO by storing HRP and GOx with luminol-GO at 4 °C overnight, to form HRP/GOx-luminol-GO bionanocomposites.