Publications by authors named "Jiabin Lai"

Purpose: The aim of this study is to analyze the changes in blood pressure after esophagectomy and the postoperative metabolic factors of esophageal cancer patients with and without combined hypertension.

Methods: Case data of 203 patients with esophageal cancer treated by esophagectomy were retrospectively collected. Patients were divided into 51 cases in the combined hypertension group and 152 cases in the uncomplicated hypertension group according to whether they had preoperative combined hypertension or not.

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Background: Chemodynamic therapy (CDT) faces challenges of low catalytic ion efficiency and ROS production. We developed a ROS nano-bomb, Cu/ZIF-8@GA-Fe, to address these issues.

Methods: The nano-bomb was synthesized by doping copper into ZIF-8 and assembling Fe and gallic acid (GA).

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Background: Osteosarcoma is a bone tumor that is characterized by high malignancy and a high mortality rate, and that originates from primitive osteoblastic mesenchymal cells and is most common in rapidly growing long bones. PSMD14, also known as RPN11 or POH1, is a member of the JAMM isopeptidase family, which is able to remove the substrate protein ubiquitination label, thereby regulating the stability and function of the substrate protein. In this study, we explored the expression and potential biological significance of the PSMD14 deubiquitinating enzyme in osteosarcoma.

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Background: Type 2 diabetes mellitus (T2DM) is a common co-morbidity in patients who receive esophagectomy and has unfavorable effects on glucose and lipid metabolism in patients. This study examines how weight and glycolipid metabolism change in patients with T2DM following esophagectomy.

Methods: This retrospective, one-center, observational analysis with a propensity score matching analysis (PSM) included 114 patients who underwent esophageal surgery in the Department of Cardiothoracic Surgery, the 900th Hospital of Joint Logistic Support Force from 2017 to 2020, which were separated into T2DM group and Non-T2DM group.

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Background: Surgery is widely regarded as a pivotal therapeutic approach for treating oesophageal cancer, and clinical observations have revealed that many oesophageal cancer patients also present with concomitant hyperlipidaemia. It is surprising that few studies have been performed to determine how blood lipid levels are affected by oesophageal cancer resection. This research was designed to assess the influence of oesophageal cancer resection on lipid profiles among individuals diagnosed with both oesophageal cancer and hyperlipidaemia.

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Autophagy and cytoskeleton integrity of chondrocytes are a considered as major factors in the progression of osteoarthritis (OA) involving excessive chondrocyte apoptosis and senescence. Nesfatin-1, an adipokine, has been reported to be closely related to cell autophagy and cytoskeleton malfunction. Our previous study found that nesfatin-1 was highly correlated with OA progress in OA patient, and the expression of nesfatin-1 rises in knee articular tissue, serum and chondrocytes.

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Article Synopsis
  • Diabetic kidney disease (DKD) can get worse because of low-grade inflammation, but a substance called Sappanone A (SA) might help fight this inflammation.
  • In a study, diabetic mice that received SA showed less kidney damage compared to those that didn't, with better kidney function results.
  • SA seems to work by blocking certain harmful signals in the body that cause inflammation and fibrosis, suggesting it could be a useful treatment for DKD.
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