Publications by authors named "Jiabao Su"
Article Synopsis
- Vascular calcification (VC) involves calcium buildup in the aorta, increasing cardiovascular risks, and the study investigates the role of nesfatin-1 in this process.
- Higher levels of nesfatin-1 were found in calcified vascular smooth muscle cells (VSMCs) and patients with coronary calcification, with experiments showing it regulates VC by promoting osteogenic transformation of VSMCs.
- The study discovered that nesfatin-1 enhances BMP-2 signaling by inhibiting SYTL4, leading to changes that promote transcription of OPN, and identified compounds like Curculigoside and Chebulagic acid that reduce VC by interacting with nesfatin-1.
Article Synopsis
- Myocardial ischemia-reperfusion injury (MIRI) is caused by restoring blood flow to heart tissue, leading to issues like oxidative stress and inflammation.
- This study explores the effects of stachyose, a natural compound, on MIRI, finding that it improves heart function and reduces damage in models of the condition.
- Stachyose works by enhancing protective pathways in heart cells and suppressing inflammatory responses in immune cells, suggesting it could be a promising treatment option for MIRI that needs further research.
The role of gut microbiome in acute kidney injury (AKI) is increasing recognized. Caloric restriction (CR) has been shown to enhance the resistance to ischemia/reperfusion injury to the kidneys in rodents. Nonetheless, it is unknown whether intestinal microbiota mediated CR protection against ischemic/reperfusion-induced injury (IRI) in the kidneys.
View Article and Find Full Text PDFBrown adipose tissue (BAT) plays a critical role in regulating cardiovascular homeostasis through the secretion of adipokines, such as fibroblast growth factor 21 (FGF21). Dexmedetomidine (DEX) is a selective α2-adrenergic receptor agonist with a protection against myocardial ischemia/reperfusion injury (MI/RI). It remains largely unknown whether or not BAT-derived FGF21 is involved in DEX-induced cardioprotection in the context of MI/RI.
View Article and Find Full Text PDFCardiometabolic diseases (CMDs) are major contributors to global mortality, emphasizing the critical need for novel therapeutic interventions. Hydrogen sulfide (HS) has garnered enormous attention as a significant gasotransmitter with various physiological, pathophysiological, and pharmacological impacts within mammalian cardiometabolic systems. In addition to its roles in attenuating oxidative stress and inflammatory response, burgeoning research emphasizes the significance of HS in regulating proteins via persulfidation, a well known modification intricately associated with the pathogenesis of CMDs.
View Article and Find Full Text PDFCichoric acid (CA), a widely utilized polyphenolic compound in medicine, has garnered significant attention due to its potential health benefits. Sepsis-induced acute kidney disease (AKI) is related with an elevated risk of end-stage kidney disease (ESKD). However, it remains unclear whether CA provides protection against septic AKI.
View Article and Find Full Text PDFArticle Synopsis
- In a study of 171 participants, FGL-1 levels were found to be significantly higher in DbCM patients compared to healthy controls and those with type 2 diabetes without DbCM.
- The study suggests that FGL-1, in combination with triglyceride levels, could help diagnose DbCM and correlate with heart function, indicating its potential as a marker for cardiac health in these patients.