Optimization and biological evaluation of l-DOPA derivatives as potent influenza PA endonuclease inhibitors with multi-site binding characteristics.

Emerging and potential influenza pandemics still are an enormous worldwide public health challenge. The PA endonuclease has been proved to be a promising target for anti-influenza drug design. Here, we report the discovery and optimization of potent Y-shaped PA inhibitors featuring multi-site binding characteristics with l-DOPA as a starting point.