Association between the oxidative balance score and testosterone deficiency: a cross-sectional study of the NHANES, 2011-2016.

There is increasing recognition of the role of oxidative balance in testosterone deficiency (TD). This study investigates the association between the oxidative balance score (OBS) and TD prevalence among adult males in the United States. Data were obtained from a cross-sectional study of 3276 adult men in the 2011-2016 National Health and Nutrition Examination Survey.

Bisboronic Ester-Enabled Redox-Targeted Cancer Therapy: A Cascade ROS Consumption Approach for Efficient Elimination of Cancer Cells.

Elevated levels of reactive oxygen species (ROS) in cancer cells, arising from their altered metabolism, represent a distinctive therapeutic target. Here, we introduce the first example of bisboronic esters as potent agents for rapidly disrupting redox homeostasis, selectively inducing oxidative stress to eliminate cancer cells. Structure-activity relationship studies revealed that both the electronic and steric factors significantly influence their cytotoxicity, with the most effective compounds achieving IC values as low as 0.

2'-FL and cross-feeding bifidobacteria reshaped the gut microbiota of infants with atopic dermatitis ex vivo and prevented dermatitis in mice post-microbiota transplantation through retinol metabolism activation.

2'-Fucosyllactose (2'-FL), a predominant human milk oligosaccharide, plays a crucial role in the development of the infant gut microbiota and immune system. However, the microbiota of infants with atopic dermatitis (AD) often has difficulty utilizing 2'-FL. Here, we found that strains from human milk, FN120 and subsp.

Interaction between imidacloprid residues in maize rhizospheric soil and soil nematode community.

Although imidacloprid has been shown to present potential risks to non-target invertebrates and vertebrates, researches exploring this risk from the perspective of the underground ecosystem remains incomplete. In this study, we determined that the presence of imidacloprid significantly reduced the abundance and diversity of soil nematodes in maize rhizospheric soil. Furthermore, imidacloprid also exerted negative effects on the body length, reproduction, locomotion, lipid accumulation, lipofuscin accumulation, and acetylcholinesterase activity in the model organism Caenorhabditis elegans.

[Application of 3D printed double positioning guide in aesthetic restoration of anterior teeth].

Purpose: To evaluate the clinical effect of 3D printing double positioning crown extension guide combined with 3D printing temporary crown in red aesthetic restoration of anterior teeth.

Methods: Twenty patients (70 teeth in total) who needed aesthetic restoration were randomly divided into 3D printing group (9 cases, 36 teeth) and traditional restoration group (11 cases, 34 teeth). The 3D printing team performed digital design, 3D printing double positioning crown lengthening guide to help crown lengthening operation, and 3D printed temporary crown was used after operation.

Hybrid phytoglycogen-dopamine nanoparticles as biodegradable underwater adhesives.

Developing adhesive materials that can selectively degrade into non-toxic by-products is a key challenge in materials science, particularly for short-term implantable devices and tissue regeneration treatments. Herein, we leverage biodegradable phytoglycogen (PG) nanoparticles (highly branched glucose polysaccharide nanoparticles) as scaffolds for coupling adhesive dopamine motifs to be used as biodegradable underwater adhesives. Phytoglycogen-dopamine (PG-dopa) hybrid nanoparticles could be synthesised in an aqueous solvent, to which the products retained a similar size and particle morphology to the initial PG nanoparticles.

The Therapeutic Efficacy and Molecular Mechanisms of Essential Oil in Treating Feline Herpesvirus Infection via Nasal Drops.

This study aimed to explore the therapeutic potential and mechanisms of Artemisia argyi essential oil (AAEO) in managing feline herpesvirus type 1 (FeHV-1) infections. FeHV-1, the causative agent of feline viral rhinotracheitis (FVR), leads to severe respiratory and systemic complications in cats. In this study, 35 cats were divided into blank, FeHV-1 infection, and AAEO treatment groups (high, medium, and low doses).

A Rare Case of an Intracardial Ectopic Thyroid in the Right Ventricle.

The ectopic thyroid gland is an abnormal development of the embryo. Most of the ectopic thyroid occurs in the path around the thyroglossal duct or on the lateral side of the neck. However, ectopic thyroid occurs in the heart, which is rare.

TBS as a complementary tool for assessing vertebral fractures and spinal deformity in children and adolescents with osteogenesis imperfecta.

Unlabelled: This study evaluated trabecular bone score (TBS) for assessing vertebral fractures and spinal deformity in children and adolescents with osteogenesis imperfecta (OI). TBS showed superior performance in identifying vertebral fractures compared to areal bone mineral density (aBMD), especially in patients without densitometric osteoporosis, suggesting its potential for monitoring vertebral fractures and spinal deformity risk.

Background: TBS, derived from a textural greyscale analysis of lumbar spine dual-energy X-ray absorptiometry (DXA) images, offers a non-invasive and indirect evaluation of bone microarchitecture.

Exosomes: a double-edged sword in cancer immunotherapy.

Over the past few decades, immunotherapy has emerged as a powerful strategy to overcome the limitations of conventional cancer treatments. The use of extracellular vesicles, particularly exosomes, which carry cargoes capable of modulating the immune response, has been extensively explored as a potential therapeutic approach in cancer immunotherapy. Exosomes can deliver their cargo to target cells, thereby influencing their phenotype and immunomodulatory functions.

The clinical performance of robotic assisted navigation system versus conventional freehand technique for percutaneous transthoracic needle biopsy.

This study aimed to assess the feasibility and safety of robotic-assisted navigation system for percutaneous transthoracic needle biopsy (PTNB), compare it with conventional freehand technique, and evaluate its generalizability across operators with varying experience levels. After excluding 5 patients in whom robotic-assisted PTNB could not be performed due to technical problems, a total of 50 patients with robotic-assisted PTNB and 200 patients who performed freehand puncture were included. Using propensity score matching (PSM) to match two groups of patients and simulate a randomized controlled scenario.

Longitudinal associations between family conflict, intergenerational transmission, and adolescents' depressive symptoms: evidence from China Family Panel studies (2016-2020).

Background: Adolescent depression is increasing globally, and family conflict may contribute to its transmission across generations. However, longitudinal evidence on these dynamics remains sparse. This study examines the longitudinal associations between family conflict and adolescents' and parents' depressive symptoms from three waves of data.

Fortification of soluble soybean polysaccharide edible films with licorice root extract for nut preservation.

In order to improve the poor mechanical properties and strong hydrophilicity of soluble soybean polysaccharide (SSPS) based films, licorice residue extract (LE) was introduced into the film-forming matrix. In this study, the effect of the amount of LE on the microstructure, physical and functional performances of the SSPS-based films, and its antioxidant activity and practical application in delaying the oxidation of oil-fried peanuts were investigated. The results showed that the compounding of LE increased the tensile strength (TS) by 4.

Advanced nanoparticle engineering for precision therapeutics of brain diseases.

Despite the increasing global prevalence of neurological disorders, the development of nanoparticle (NP) technologies for brain-targeted therapies confronts considerable challenges. One of the key obstacles in treating brain diseases is the blood-brain barrier (BBB), which restricts the penetration of NP-based therapies into the brain. To address this issue, NPs can be installed with specific ligands or bioengineered to boost their precision and efficacy in targeting brain-diseased cells by navigating across the BBB, ultimately improving patient treatment outcomes.

Harnessing the power of breast milk: how FN029 from rural western China mitigates severe atopic dermatitis in mice through retinol metabolism activation.

Tongwei and Wuxi represent a rural county in western China and an industrialized city in the east, respectively. The study compared breast milk and the corresponding infant gut microbiota from 35 healthy mothers in Tongwei and 28 in Wuxi, uncovering significant differences in microbial alpha and beta diversity. A unique strain, FN029, characteristically transmitted from breast milk to the infant gut in Tongwei, was identified.

AI-driven evidence synthesis: data extraction of randomized controlled trials with large language models.

The advancement of large language models (LLMs) presents promising opportunities to enhance evidence synthesis efficiency, particularly in data extraction processes, yet existing prompts for data extraction remain limited, focusing primarily on commonly used items without accommodating diverse extraction needs. This research letter developed structured prompts for LLMs and evaluated their feasibility in extracting data from randomized controlled trials (RCTs). Using Claude (Claude-2) as the platform, we designed comprehensive structured prompts comprising 58 items across six Cochrane Handbook domains and tested them on 10 randomly selected RCTs from published Cochrane reviews.

Global burden and cross-country inequalities of nutritional deficiencies in adults aged 65 years and older, 1990-2021: population-based study using the GBD 2021.

Background/objectives: Nutritional deficiencies remain significant public health issues in older populations globally. This study evaluates the burden, trends, and cross-country inequalities of four common nutritional deficiencies (protein-energy malnutrition, iodine deficiency, vitamin A deficiency, and dietary iron deficiency) in older adults from 1990 to 2021.

Methods: Age-standardised prevalence, disability-adjusted life years (DALYs), and average annual percentage changes (AAPCs) of these deficiencies in people aged ≥ 65 years at global, regional, and national levels were estimated from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021.

Language models for data extraction and risk of bias assessment in complementary medicine.

Large language models (LLMs) have the potential to enhance evidence synthesis efficiency and accuracy. This study assessed LLM-only and LLM-assisted methods in data extraction and risk of bias assessment for 107 trials on complementary medicine. Moonshot-v1-128k and Claude-3.

Inhibiting NLRP3 enhances cellular autophagy induced by outer membrane vesicles from .

The bacterium is able to invade lung epithelial cells and survive intracellularly. During this process, it secretes outer membrane vesicles (OMVs), however, it is currently unclear how OMVs from (PA-OMVs) affect lung epithelial cells and their impact on oxidative stress, autophagy, and other physiological activities of lung epithelial cells. In this study, we found that PA-OMVs activated oxidative stress and autophagy in cells.

Rational Design Two- or Four-Electron Reaction Pathway Covalent Organic Frameworks for Efficient and Selective Electrocatalytic Hydrogen Peroxide Production.

Covalent organic frameworks (COFs) are often employed in oxygen reduction reactions (ORR) for hydrogen peroxide production due to their tunable structures and compositions. However, COF electrocatalysts require precise structural engineering, such as heteroatoms or metal site doping, to modulate the reaction pathway during the ORR process. In this work, we designed a tetraphenyl-p-phenylenediamine based COF electrocatalyst, namely TPDA-BDA, which exhibited excellent two-electron (2e) ORR performance with high HO selectivity of 89.

Qualitative and Quantitative Analyses of 1-Aminocyclopropane-1-carboxylic Acid Concentrations in Plants Organs Using Phenyl Isothiocyanate Derivatization.

1-Aminocyclopropane-1-carboxylic acid (ACC) is a direct precursor of phytohormone ethylene. We used a phenyl isothiocyanate (PITC) derivatization modification method combined with spectrographic analysis to isolate and identify three products of the derivatization reactions of ACC and PITC. The MRM mode of UPLC-MS/MS was used to establish the analysis of 6-phenyl-5-thioxo-4,6-diazaspiro[2.

Different regimens of preoperative carbohydrate loading on insulin resistance: A network meta-analysis.

Background & Aims: The effectiveness of preoperative carbohydrate loading(PCL) on postoperative insulin resistance(IR) is controversial. In addition, the effect of different doses of carbohydrates on postoperative IR is also controversial. Therefore, this study aimed to investigate the efficiency of PCL on postoperative IR and the optimal regimen for the effect on postoperative IR.

Establishment of fingerprint of phenolic compounds in and study on the spectrum-effect relationship based on different preceding cropping areas.

As an agricultural planting practice, preceding cropping can not only enhance soil fertility and reduce pests and diseases but also boost crop yield and quality. In this study, SZS samples from different preceding cropping areas were selected as research subjects. Phenolic compounds were analyzed using high-performance liquid chromatography (HPLC), and antioxidant activities were assessed based on free radical scavenging effects.

Microalgae-based biofertilizers improve fertility and microbial community structures in the soil of potted tomato.

Continuous cropping decreases soil nutrients and destroys microbial community structure, so the development of eco-friendly and effective biofertilizers is necessary under present conditions. In this study, the preserving microalgal strain sp. (H) was firstly selected to be combined with agroforestry waste (shell powder, straw fermentation liquid) and the agroforestry microorganism sp.

Design, synthesis, and anti-liver fibrosis activity of novel non-steroidal vitamin D receptor agonists based on open-ring steroid scaffold.

Vitamin D receptor (VDR) has emerged as a crucial target for the treatment of hepatic fibrosis, a condition characterized by excessive deposition of extracellular matrix (ECM) components leading to impaired liver function. Activation of VDR has been shown to inhibit the transformation of hepatic stellate cells (HSCs), which play a key role in the development of liver fibrosis, thus reducing ECM production. In this study, a series of 37 non-steroidal VDR agonists with novel scaffold were designed and synthesized utilizing the scaffold hopping strategy.