Targeting GATA6 with pedunculoside inhibits fetal gene expression to attenuate pathological cardiac hypertrophy.

Background: Pathological cardiac hypertrophy is a characteristic feature of numerous cardiovascular diseases and significantly impacts human health. However, effective treatment options for cardiac hypertrophy are still significantly unmet. Pedunculoside, a pentacyclic triterpenoid saponin from the traditional Chinese herb Ilex rotunda Thunb.

Crack-Detection Algorithm Integrating Multi-Scale Information Gain with Global-Local Tight-Loose Coupling.

In this study, an improved target-detection model based on information theory is proposed to address the difficulties of crack-detection tasks, such as slender target shapes, blurred boundaries, and complex backgrounds. By introducing a multi-scale information gain mechanism and a global-local feature coupling strategy, the model has significantly improved feature extraction and expression capabilities. Experimental results show that, on a single-crack dataset, the model's mAP@50 and mAP@50-95 are 1.

Assessing the feasibility of a bowel management program for patients with neurogenic bowel function after spinal cord injury.

The aim of this study was to assess the feasibility of a bowel management program for patients with neurogenic bowel function after spinal cord injury. The program is based on evidence-based nursing, expert meeting and pre-experiment construction, the construction process is standardized and scientific, and the content is comprehensive, mainly includes 4 dimensions of bowel assessment, bowel intervention, assessment indices and discharge follow-up, which were carried out at the time of admission (T1), discharge (T2) and 1 month after discharge (T3) of patients in the experimental group, while the control group used routine orthopedic bowel management, and bowel function indices, quality of life and laboratory tests were used as outcome indices, and differences in the observed indices of patients in the two groups were compared to validate the effect of the program. Compared with the control group, the incidence of bloating, constipation and fecal incontinence was significantly reduced in the experimental group, while the frequency of defecation scores, fecal character scores, Neurogenic Bowel Dysfunction scores, laboratory test results and quality of life were also effectively improved.

Histone demethylases in autophagy and inflammation.

Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase, are actively associated not only with oncogenesis but also with inflammatory responses.

Deficiency of hepatokine orosomucoid1 aggravates NAFLD progression in mice.

Orosomucoid (ORM) is an important hepatokine that regulates metabolism. Previous report showed that isoform ORM2 but not ORM1 could downregulate lipogenic genes and ameliorate hepatic steatosis in obese mice, thereby categorizing ORM2 as a promising candidate for therapeutic intervention in nonalcoholic fatty liver disease (NAFLD). However, our previous studies found that mice lacking ORM1 gradually developed an obese phenotype with severe hepatic steatosis at the age of 24 weeks.

Structures and Biological Activities of Secondary Metabolites from spp.

The genus have long been recognized as a source of structural novel, pharmaceutically relevant natural products. We reviewed the structures and activities of secondary metabolites isolated from the genus of from January 1995 to June 2024, and 280 compounds, including six major categories-terpenoids, alkaloids, polyketides, polyphenols, steroids, and other classes-are presented in this review. Among these metabolites, 196 were identified as new structures.

Dual-Targeted Drug Delivery to Myeloid Leukemia Cells via Complement- and Transferrin-Based Protein Corona.

Although traditionally regarded as an impediment, the protein corona can facilitate the advancement of targeted drug delivery systems. This study presents an innovative approach for targeting acute myeloid leukemia (AML) using nanoparticles with agglutinated protein (NAPs). Agglutinated transferrin and C3b in NAPs selectively bind to CD71 and CD11b, receptors that are overexpressed on myeloid leukemic cells compared to nonmalignant cells.

Cyanidin-3-rutinoside from Mori Fructus ameliorates dyslipidemia via modulating gut microbiota and lipid metabolism pathway.

Dyslipidemia is responsible for pathologies of cardiovascular diseases and gut microbiota plays an essential role in lipid metabolism. Dietary supplementation is an important supplement to medicine in management of dyslipidemia. Mori Fructus is a popular Asia medical food with various pharmacological benefits including anti-hyperlipidemia.

Developing a Ready-to-Use Lipid Nanoparticle Technology for Nucleic Acid Delivery Based on Deep Eutectic Solvents.

Microfluidic technology has emerged as a prevalent tool to produce lipid nanoparticles (LNPs) for nucleic acid delivery. However, its wide-ranging application is hindered by specialized, costly equipment and consumables. Herein, a ready-to-use lipid nanoparticle (RULNP) technology employing deep eutectic solvents (DESs) was developed.

Regenerated fat induced by a decellularized adipose matrix can survive long-term in vivo.

Decellularized adipose matrix (DAM) is considered to be the most potential biological scaffold for soft tissue repair and reconstruction, as it is able to induce the regeneration of adipose tissue in situ in adulthood. But how does this adipose tissue regeneration happen and develop in vivo? Is it the same as the original autologous one? Temporary existence or long-term survival? These are the key questions that will determine the future applications of DAM. In this study, we investigated the composition, structure and biomechanical properties of DAM before implanting it into the subcutaneous back of immunodeficient mice.

Orosomucoid 2 is an endogenous regulator of neuronal mitochondrial biogenesis and promotes functional recovery post-stroke.

Development of functional recovery therapies is critical to reduce the global impact of stroke as the leading cause of long-term disability. Our previous studies found that acute-phase protein orosomucoid (ORM) could provide an up to 6 h therapeutic time window to reduce infarct volume in acute ischemic stroke by improving endothelial function. However, its role in neurons and functional recovery post-stroke remains largely unknown.

The role of arbuscular mycorrhizal fungi in micronutrient homeostasis and cadmium uptake and transfer in rice under different flooding intensities.

Flooding intensity significantly alters the availability of iron (Fe), zinc (Zn), and cadmium (Cd) in paddy soil. However, the influence of arbuscular mycorrhizal fungi (AMF) on the uptake and transfer of Cd and micronutrients (Fe and Zn) under Cd stress in varying flooding conditions is not well understood. A pot experiment was conducted to investigate the micronutrient homeostasis and Cd uptake and transfer in rice cultivated in Cd-contaminated soil with AMF inoculation under continuous and intermittent flooding conditions.

Arbuscular Mycorrhizal Fungi Mediate the Acclimation of Rice to Submergence.

Flooding is a critical factor that limits the establishment of a symbiosis between rice and arbuscular mycorrhizal fungi (AMF) in wetland ecosystems. The distribution of carbon resources in roots and the acclimation strategies of rice to flooding stress in the presence of AMF are poorly understood. We conducted a root box experiment, employing nylon sheets or nylon meshes to create separate fungal chambers that either prevented or allowed the roots and any molecules to pass through.

Plant litter as a heavy metal migration strategy following application of sewage sludge to subtropical forest soils.

The environmental risks of migration of heavy metals (HMs) following applications of sewage sludge (SS) to forest soils are garnering increased attention. Plant litter at the forest floor may modify HM migration pathways through impacts on soil aggregates and water/soil erosion; however, HM migration responses to plant litter are poorly understood. The aim of this study was to determine the effects of plant litter cover on HMs migration, and water and soil erosion following the application of SS to subtropical forest soils.

Activation of α7 Nicotinic Acetylcholine Receptor Improves Muscle Endurance by Upregulating Orosomucoid Expression and Glycogen Content in Mice.

There are presently no acknowledged therapeutic targets or official drugs for the treatment of muscle fatigue. The alpha7 nicotinic acetylcholine receptor (α7nAChR) is expressed in skeletal muscle, with an unknown role in muscle endurance. Here, we try to explore whether α7nAChR could act as a potential therapeutic target for the treatment of muscle fatigue.

A non-antibiotic erythromycin derivative improves muscle endurance by regulating endogenous anti-fatigue protein orosomucoid in mice.

At present, there are no official approved drugs for improving muscle endurance. Our previous research found acute phase protein orosomucoid (ORM) is an endogenous anti-fatigue protein, and macrolides antibiotics erythromycin can elevate ORM level to increase muscle bioenergetics and endurance parameters. Here, we further designed, synthesized and screened a new erythromycin derivative named HMS-01, which lost its antibacterial activity in vitro and in vivo.

Microplasma radio frequency technology using stationary tips on pig skin: A histological study.

Objective: To investigate the histological properties of microplasma radiofrequency (MPRF) using a stationary tip in different treatment strategies on porcine skin.

Methods: Two Bama miniature pigs received MPRF treatment with two types of stationary tips in eight groups of parameters (power, duration, and pass) on dorsal skin. Skin samples were collected from each treatment zone immediately, at 1 week and 1, 3, and 6 months after treatment.

Dual-functional heterogeneous Fenton catalyst Cu/Ti co-doped FeO@FeOOH for cyanide-containing wastewater treatment: Preparation, performance and mechanism.

The dual-functional heterogeneous Fenton catalyst Cu/Ti co-doped iron-based Fenton catalyst (Cu/Ti -FeO@FeOOH, FCT) were successfully prepared by precipitation oxidation method and characterized by XRD, XPS and XAFS. The prepared Cu/Ti co-doped FeO@FeOOH nanoparticles consisted of goethite nanorods and magnetite rod octahedral particles, with Cu and Ti replacing Fe in the catalyst crystal structure, leading to the formation of the goethite structure. The heterogeneous Fenton catalyst FCT exhibited excellent degradation activity for cyanide in wastewater and showed different reaction mechanisms at varying pH levels.

A Hydrogen Evolution Catalyst [CoO] Metallacycle Enables Regioselective Allene C(sp)-H Functionalization.

Selective functionalization of allenic C(sp)-H is an ideal approach to upgrading simple allenes to synthetically useful allenes, albeit suffering from challenges associated with inert reactivity and inferior selectivity. Inspired by energy chemistry, a catalytic hydrogen evolution reaction (HER) strategy was leveraged to selectively activate weakly acidic allene C(sp)-H bonds in a reductive mode. An array of [CoO] metallacycle complexes were readily devised starting from amino acids, and they were demonstrated as robust HER catalysts, which would selectively break allenic C(sp)-H bonds to release hydrogen.

Harnessing fine fibers in decellularized adipose-derived matrix for enhanced adipose regeneration.

Decellularized Adipose-Derived Matrix (DAM) has the function of inducing adipogenesis, but the distribution of adipogenesis is uneven. We found for the first time that DAM contains two structural components: The tough fibers DAM (T-DAM) and the fine fibers DAM (F-DAM). T-DAM was a dense vortex structure composed of a large number of coarse fibers, characterized by myoblast-related proteins, which cannot achieve fat regeneration and forms a typical "adipose-free zone".

A Visualization Method of Knowledge Graphs for the Computation and Comprehension of Ultrasound Reports.

Knowledge graph visualization in ultrasound reports is essential for enhancing medical decision making and the efficiency and accuracy of computer-aided analysis tools. This study aims to propose an intelligent method for analyzing ultrasound reports through knowledge graph visualization. Firstly, we provide a novel method for extracting key term networks from the narrative text in ultrasound reports with high accuracy, enabling the identification and annotation of clinical concepts within the report.

Efficient extraction performance and mechanisms of Cd and Pb in water by novel dicationic ionic liquids.

Ten novel hydrophobic dicationic ionic liquids (DILs) were synthesized and applied for the extraction of heavy metals in aqueous solutions. Their physicochemical properties were measured at ambient temperature, and the leaching behaviors of the as-prepared DILs in water were assessed by TOC analysis. Metal extraction experiments were carried out to evaluate the extraction performances of the DILs.