Structural characteristics of a heteropolysaccharide from Ganoderma lucidum and its protective effect against Alzheimer's disease via modulating the microbiota-gut-metabolomics.

Ganoderma lucidum is a traditional Chinese medicine used to treat Alzheimer's disease (AD), whose main active ingredient is polysaccharides. A heteropolysaccharide named GLPZ-1 was isolated from Ganoderma lucidum. GLPZ-1 (6.

Single-Molecule Observation of Competitive Protein-Protein Interactions Utilizing a Nanopore.

Two or more protein ligands may compete against each other to interact transiently with a protein receptor. While this is a ubiquitous phenomenon in cell signaling, existing technologies cannot identify its kinetic complexity because specific subpopulations of binding events of different ligands are hidden in the averaging process in an ensemble. In addition, the limited time resolution of prevailing methods makes detecting and discriminating binding events among diverse interacting partners challenging.

Anaerobic co-biodegradation of polyhydroxyalkanoate and swine manure for volatile fatty acid production: The impact of C/N ratios and microbial dynamics.

Polyhydroxyalkanoate (PHA) is the important biodegradable plastic, however, biodegradation of PHA waste in anaerobic environments emits more CH, a potent greenhouse gas. Bioconversion of PHA waste to useful byproducts - volatile fatty acids (VFAs) is a practical method to upcycle carbon from PHA. In this study, PHA waste was anaerobically co-digested with swine manure (SM) (the typical high nitrogen waste) at different C/N ratios.

Precursor engineering towards orange- and red-emissive carbon dots for LEDs with tunable emission colors.

Carbon dots (CDs) have attracted significant research interest due to their great potential in optoelectronic applications. Although various CDs have been synthesized the "bottom-up" pathway, few studies have focused on understanding the origins of the structural and optical diversities of CDs. In this study, two benzenoid acids with a slight structural variation (, 9-oxo-9-fluorene-2,7-dicarboxylic acid (FR) and 4,4'-biphenyl dicarboxylic acid (BP)) are employed as precursors, yielding orange- and red-emissive CDs with quantum yields of 43.

Lactylation and Ischemic Stroke: Research Progress and Potential Relationship.

Ischemic stroke is caused by interrupted cerebral blood flow and is a leading cause of mortality and disability worldwide. Significant advancements have been achieved in comprehending the pathophysiology of stroke and the fundamental mechanisms responsible for ischemic damage. Lactylation, as a newly discovered post-translational modification, has been reported to participate in several physiological and pathological processes.

Exploring the regional cooling efficiency of urban residential vegetation using scenario simulation.

The study of the cooling efficiency of vegetation in urban residential areas at a micro-scale is important for improving the thermal environment of those areas. The quantitative analysis of the effect of the layout of different building patterns on the cooling efficiency of green space is particularly crucial. This study takes a typical residential area with a row-column arrangement in Jiangning District, Nanjing City, Jiangsu Province, China, as the research object.

The prognostic significance of lncRNA FGD5-AS1 in various malignancies: a meta-analysis.

Background: Cancer is widely recognized as a prominent contributor to global mortality due to factors such as delayed diagnosis, unfavorable prognosis, and high likelihood of recurrence. FGD5 transcription factor G antisense RNA 1(FGD5-AS1), a newly identified long non-coding RNA, has emerged as a promising prognostic biomarker, for malignancy prognosis. This meta-analysis aimed to assess the prognostic significance of FGD5-AS1 in various carcinomas.

Simulations of Femtosecond-Laser Near-Field Ablation Using Nanosphere under Dynamic Excitation.

Femtosecond lasers have garnered widespread attention owing to their subdiffraction processing capabilities. However, their intricate natures, involving intrapulse feedbacks between transient material excitation and laser propagation, often present significant challenges for near-field ablation predictions and simulations. To address these challenges, the current study introduces an improved finite-difference time-domain method (FDTD)-plasma model (plasma)-two-temperature model (TTM) framework for simulating the ablation processes of various nanospheres on diverse substrates, particularly in scenarios wherein dynamic and heterogeneous excitations significantly influence optical-field distributions.

A study of latent profile analysis of empathic competence and factors influencing it in nursing interns: a multicenter cross-sectional study.

Background: Empathy, as one of the fundamental principles of nursing professionalism, plays a pivotal role in the formation and advancement of the nursing team. Nursing interns, as a reserve force within the nursing team, are of significant importance in terms of their ability to empathize. This quality is not only directly related to the degree of harmony in the nurse-patient relationship and the enhancement of patient satisfaction, but also plays a pivotal role in the promotion of the quality of nursing services to a new level.

Metagenomics reveals unique gut mycobiome biomarkers in psoriasis.

Purpose: In present, the diagnosis of psoriasis is mainly based on the patient's typical clinical manifestations, dermoscopy and skin biopsy, and unlike other immune diseases, psoriasis lacks specific indicators in the blood. Therefore, we are required to search novel biomarkers for the diagnosis of psoriasis.

Methods: In this study, we analyzed the composition and the differences of intestinal fungal communities composition between psoriasis patients and healthy individuals in order to find the intestinal fungal communities associated with the diagnosis of psoriasis.

Treatment of colorectal cancer by traditional Chinese medicine: prevention and treatment mechanisms.

Colorectal cancer (CRC) is a significant global health burden, with high morbidity and mortality rates. It is often diagnosed at middle to advanced stage, affecting approximately 35% of patients at the time of diagnosis. Currently, chemotherapy has been used to improve patient prognosis and increase overall survival.

Regulation of Fuzheng Huayu capsule on inhibiting the fibrosis-associated hepatocellular carcinogenesis.

In the current study, bioinformatics analysis of the hepatocellular carcinoma (HCC) dataset was conducted with the hepatoprotective effect of the Fuzheng Huayu (FZHY) capsule against the diethylnitrosamine-induced HCC progression analyzed. Eight cell clusters were defined and , , and , compounds of the FZHY capsule, inhibit HCC progression-related fibrosis by regulating the expression of and . Combined with the ameliorative effect of the FZHY capsule against liver dysfunctions and expression of PLAU and IGFBP3, our study confirmed the effect of the FZHY capsule on inhibiting the fibrosis-associated HCC progression regulating the expression of PLAU and IGFBP3.

Moderately reducing N input to mitigate heat stress in maize.

In a warming climate, high temperature stress greatly threatens crop yields. Maize is critical to food security, but frequent extreme heat events coincide temporally and spatially with the period of kernel number determination (e.g.

Dynamic optimization of battery recycling e-platforms under non-equalizing supply and demand: Recycling price and service commissions.

With the rapid advancement of electric vehicles (EVs), the burgeoning increase in used power batteries necessitates the development of efficient battery recycling e-platforms. A key challenge in this field is the mismatch between supply and demand. In response, a dynamic optimization model is proposed to capture the non-equalizing supply-demand relationship and its linkage over continuous periods to enable dynamic simulations and predictions of transaction volume changes.

Improving the green space arrangement in residential areas from the perspective of tree leaf temperature utilizing scenario simulation in ENVI-met.

Studying the differences in leaf temperature and their mechanisms can help us accurately understand the microenvironment in which plants are located. In this paper, typical residential areas in Jianye District, Nanjing, Jiangsu Province, China, are selected as the research area, we investigated the suitability of green space configurations from the perspective of tree leaf temperature of residential areas based on the scenario simulation in ENVI-met. Firstly, twenty abstract models were constructed, including four kinds of aspect ratio of trees (ARTs) which can be used to indicate the different green space arrangement and two typical tree species, camphora tree and platanus tree.

Full-day profiling of a beam attenuation coefficient using a single-photon underwater lidar with a large dynamic measurement range.

A compact underwater lidar system, utilizing a single-photon detection technology, is proposed to effectively eliminate interference from the sea-air interface and enhance the accuracy of water optical property measurements. However, the high sensitivity of the single-photon detector poses challenges, including daytime operation difficulties due to strong solar radiation noise and detector saturation from near-field lidar signals. To address these issues, the laser and optical receiver of the lidar are optimized to suppress solar radiation noise, and a dual-telescope structure is introduced to improve the dynamic measurement range beyond 70 dB.

Day and night continuous high-resolution shallow-water depth detection with single-photon underwater lidar.

Single-photon lidar has emerged as a strong technology for bathymetric measurements. However, its heightened sensitivity additionally makes it susceptible to solar radiation noise, particularly in the green light wavelength where solar radiation is strong, posing challenges for its daytime operation. To address this issue, a single-photon underwater lidar system is proposed and demonstrated.

Crystalline architectures of C with tunable morphology and linearly polarized red emission.

Fullerene-based micro/nano-architectures (FMNAs) with remarkable photoluminescence (PL) emissions have attracted considerable interest as potential building blocks for optical and biolabeling applications, by virtue of their low toxicity and environmentally friendly nature. Nevertheless, the PL polarization properties of FMNAs have rarely been explored. Herein, we demonstrate the preparation of highly crystalline architectures of C, which exhibit polymorphism depending on the preparation conditions but possess similar hexagonal close-packed (hcp) structures.

Comparison of Multiple Strategies for Precision Transgene Knock-In in Genome via Microhomology-Mediated End Joining.

Precision exogenous gene knock-in is an attractive field for transgenic (chicken) generation. In this article, we constructed multiple Precise Integration into Target Chromosome (PITCh) plasmid systems mediated by microhomology-mediated end-joining (MMEJ) for large-fragment integration in DF-1 cells and further assess the possibility of (glyceraldehyde-3-phosphate dehydrogenase) as a genomic safe harbor for chickens. We designed three targeted sgRNAs for the all-in-one plasmid at the 3'UTR of near the stop codon.

A novel copper-based nanozyme: fabrication and application for colorimetric detection of resveratrol.

A novel nanozyme (urea@Cu-NF) was synthesized by self-assembly of urea and copper phosphate with urea as plasticizer. Urea@Cu-NF exhibited excellent peroxidase-like activity with the ability to oxidize TMB in the presence of HO. However, its peroxidase-like activity could be inhibited by resveratrol, leading to an absorption decrease in the intensity of oxTMB.

Controllable Photoreduction of Graphene Oxide/Gold Composite Using a Shaped Femtosecond Laser for Multifunctional Sensors.

The mixture of graphene oxide and noble metal nanoparticles has been widely used in flexible multifunctional sensors. Femtosecond lasers are regarded as useful tools for sensor fabrication through direct inscribing. Normally, the laser power is adjusted to optimize the sensing performances.

Causal relationship between psychiatric traits and temporomandibular disorders: a bidirectional two-sample Mendelian randomization study.

Objectives: This study was to investigate the causal relationship between temporomandibular disorders (TMD) and psychiatric disorders by Mendelian randomization (MR) analysis.

Materials And Methods: A two-sample bidirectional MR analysis was adopted to systematically explore the causal relationship between TMD and eight psychiatric traits, including anxiety disorder (AD), panic disorder (PD), major depressive disorder (MDD), neuroticism, attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BIP), and schizophrenia (SCZ). Inverse variance weighted (IVW), weighted median, and MR-Egger regression were used in my study.

Combined Doxorubicin Mesoporous Carbon Nanospheres for Effective Tumor Lymphatic Metastasis by Multi-Modal Chemo-Photothermal Treatment in vivo.

Introduction: Sentinel lymph node (SLN) is the first regional lymph node where tumor cells metastasize, and its identification and treatment are of great significance for the prevention of tumor metastasis. However, the current clinical modalities for identification and treatment of SLN are still far from satisfactory owing to their high cost, invasiveness and low accuracy. We aim to design a novel nanomedicine system for SLN imaging and treatment with high efficacy.