Urbanization enhances consumer protist-driven ARGs dissemination in riverine ecosystems.

Despite the emergence of antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARBs), how biological inter-trophic interactions, modulated by watershed urbanization, shape the resistome remains unexplored. We collected water samples from the highly urbanized (western: 65 % built land, sewage-affected) and lesser-urbanized (northern: 25 % built land, drinking water source) downstream tributaries of the Jiulong River in southeast China over dry and wet seasons. We utilized metagenomic and amplicon (16S and 18S rDNA) sequencing to investigate the relationships among microeukaryotic algae, consumer protists, bacterial communities, and the resistome.

Enhancing Stability and 6C Fast Charging in µSi||LiNiCoMnO Lithium-Ion Batteries Using Conductive Binders With Multiple Hydrogen Bonds.

Micro-sized silicon (µSi) anodes are an attractive alternative to graphite for high-energy lithium-ion batteries (LIBs) due to their low cost and high specific capacity. However, they suffer from severe volume expansion during lithiation, leading to fast capacity decay and poor rate capability. Herein, a new hybrid binder featuring a cross-linked conductive network and multiple hydrogen bonds for µSi anodes with high areal capacity is reported.

Disrupting Heroin-Associated Memory Reconsolidation through Actin Polymerization Inhibition in the Nucleus Accumbens Core.

Background: Understanding drug addiction as a disorder of maladaptive learning, where drug-associated or environmental cues trigger drug cravings and seeking, is crucial for developing effective treatments. Actin polymerization, a biochemical process, plays a crucial role in drug-related memory formation, particularly evident in conditioned place preference (CPP) paradigms involving drugs like morphine and methamphetamine. However, the role of actin polymerization in the reconsolidation of heroin-associated memories remains understudied.

Exosomes containing circSCP2 in colorectal cancer promote metastasis via sponging miR-92a-1-5p and interacting with PTBP1 to stabilize IGF2BP1.

Exosomes have emerged as significant biomarkers for multiple diseases, including cancers. Circular RNAs (circRNAs), abundant in exosomes, are involved in regulating cancer development. However, the regulatory function and the underlying molecular mechanism of hsa_circ_0006906 (circSCP2) in colorectal cancer (CRC) metastasis remain unclear.

Enhancing the Electrochemical Energy Storage of Metal-Organic Frameworks: Linker Engineering and Size Optimization.

The electric conductivity and charge transport efficiency of metal-organic frameworks (MOFs) dictate the effective utilization of built-in redox centers and electrochemical redox kinetics and therefore electrochemical performance. Reticular chemistry and the tunable microcosmic shape of MOFs allow for improving their electric conductivity and charge transfer efficiency. Herein, we synthesized two Ni-MOFs (Ni-tdc-bpy and Ni-tdc-bpe) by the solvothermal reaction of Ni ions with 2,5-thiophenedicarboxylic acid (Htdc) in the presence of conjugated 4,4'-bipyridyl (bpy) and 1,2-di(4-pyridyl)ethylene (bpe) coligands, respectively.

Electrochemical Desaturation and β-Thiocyanation of Cyclic Amides.

The site-selective functionalization of cyclic amides provides an attractive protocol for the synthesis of valuable molecules. We report herein an electrochemical desaturation and β-thiocyanation of cyclic amides under external oxidant-free conditions. This method exhibits broad functional group tolerance, excellent selectivity, mild reaction conditions and can be applied for late-stage functionalization of bioactive molecules.

Association and predictive ability between significant perioperative cardiovascular adverse events and stress glucose rise in patients undergoing non-cardiac surgery.

Background: The predictive importance of the stress hyperglycemia ratio (SHR), which is composed of admission blood glucose (ABG) and glycated hemoglobin (HbA1c), has not been fully established in noncardiac surgery. This study aims to evaluate the association and predictive capability the SHR for major perioperative adverse cardiovascular events (MACEs) in noncardiac surgery patients.

Methods: Individuals who underwent noncardiac surgical procedures between 2011 and 2020, including both diabetic and non-diabetic patients, were identified in the perioperative medicine database (INSPIRE 1.

Effects of Prolactin Inhibition on Lipid Metabolism in Goats.

Prolactin (PRL) has recently been found to play a role in lipid metabolism in addition to its traditional roles in lactation and reproduction. However, the effects of PRL on lipid metabolism in liver and adipose tissues are unclear. Therefore, we aimed to study the role of PRL on lipid metabolism in goats.

Novel insights into Cntnap4 in Alzheimer's disease: Intestinal flora interaction.

Alzheimer's disease (AD) is a neurodegenerative disorder with unclear etiology. This study employs single-cell RNA sequencing (scRNA-seq), high-throughput transcriptome sequencing, 16s rRNA sequencing, and animal experiments to investigate the role of the contactin-associated protein like-4 (Cntnap4) gene in AD and its interaction with intestinal flora. We found that Cntnap4 deficiency in AD mice led to increased Tau protein phosphorylation, amyloid-beta plaque accumulation, and neuronal loss.

Efgartigimod treatment in patients with anti-MuSK-positive myasthenia gravis in exacerbation.

Background: The prevalence of patients positive for muscle-specific kinase antibody (hereafter, MuSK-Ab) accounts for 5-8% of all myasthenia gravis (MG) cases. Currently, efgartigimod has shown good therapeutic effects in MUSK-Ab-positive MG patients in a phase III clinical trial. However, phase III clinical trials tend to exclude MG patients in exacerbation, and there are only few real-world studies on the efficacy of efgartigimod in MuSK-Ab-positive myasthenic crisis (MC) patients.

Superior Capacitive Energy Storage Enabled by Molecularly Interpenetrating Interfaces in Layered Polymers.

Polymer dielectrics are essential for advanced electronics and electrical power systems, yet they suffer from low energy density (U) due to their low dielectric constant (K) and the inverse relationship between K and breakdown stength (E). Here a scalable approach utilizing the designed molecularly interpenetrating interfaces is presented to achieve all-organic dielectric polymers with high U and charge-dischage efficiency (η). Distinctive intermolecular interactions and microstructural changes, as demonstrated experimentally and theoretically, are introduced by the molecularly interpenetrating interfaces, resulting in simultaneous improvements in dielectric responses and mechanical strength while inhibiting electrical conduction - outcomes unattainable in conventional layered polymers.

Renal microangiopathy induced by lenvatinib in hepatocellular carcinoma: a case report and literature review.

Lenvatinib, a multi-target inhibitor of receptor tyrosine kinases, has been increasingly used in the treatment of advanced hepatocellular carcinoma (HCC). However, its association with renal adverse effects, including proteinuria and renal microvascular complications, was not fully understood in HCC patients. We reported a case of a 68-year-old male with a history of hypertension, diabetes mellitus, and hepatitis C virus (HCV) infection, diagnosed with primary HCC in 2015.

Ultrasonication-Induced Preparation of High-Mechanical-Strength Microneedles Using Stable Silk Fibroin.

Silk fibroin (SF) is an ideal material for microneedle (MN) preparation. However, long extraction and short storage durations limit its application. Furthermore, MNs prepared from SF alone are easy to break during skin insertion.

Energy Metabolite, Immunity, Antioxidant Capacity, and Rumen Microbiota Differences Between Ewes in Late Gestation Carrying Single, Twin, and Triplet Fetuses.

The objective of this study was to investigate the differences in the energy metabolites, immunity, antioxidant capacity, and rumen microbiota of ewes with different numbers of fetuses. Thirty healthy ewes were selected and divided into single- (SL, = 10), twin- (TL, = 10), and triplet-fetal (PL, = 10) ewes according to the number of fetuses. Sampling was carried out on days 21 (Q21) and 7 (Q7) before lambing.

Intermolecular Forces-Oriented Growth of MOF-on-MOF Heterostructures.

Well-controlled conjugation of distinct metal-organic frameworks (MOFs) with dissimilar components and structures into a multi-component MOF system is important for the design of myriad materials with structural complexity, integrated properties, and desired applications. Herein, we developed an interesting integration strategy that relies on intermolecular force, and which can overcome the difference in lattice parameters. The strategy uses the pre-formed MOF matrixes as seeds to direct the self-assembly of secondary MOF particles for the construction of hybrid MOFs.

Job Satisfaction Among Faculty in Standardized Residency Training Programs in Heilongjiang Province, China: A Cross-Sectional Study.

Purpose: Job satisfaction among faculty in standardized residency training programs has been underexplored. The objective of this study is to investigate job satisfaction among these faculty members and identify associated determinants.

Methods: An online cross-sectional survey was conducted with 4581 teachers in Heilongjiang Province from 18 to 30 May 2022, using a census method.

Ground-to-air aircraft infrared image deblurring based on imaging degradation simulation.

The issue of infrared image deblurring has been a significant concern. However, in some specific scenes, the current mainstream deblurring algorithms based on optimization or deep learning fail to provide satisfactory results. Aiming to address the ineffectiveness of deep learning methods due to the low-cost datasets' unavailability for specific scenes, we innovatively propose a relatively simple full-chain imaging degradation simulation method using ground-to-air aircraft infrared imaging scene as an example, which considers the effects of blur and noise caused by the atmosphere, imaging system, target motion and detector.

Protein-Based 2D Nanoarchitectures Constructed by Heterochiral π-Stacking Dimerization of Helical Foldamers.

In this study, we focus on the designability and controllability of the interaction interface between secondary structures, and discover an important interface interaction between helical secondary structures by non-covalent synthesis along the helical axis. The formation of discrete heterochiral dimers consisting of left-handed helix and right-handed helix not only helps to discover nonclassical supramolecular chirality phenomena, but also enables controllable protein assembly. Highly ordered nanostructures were thus constructed using π-stacking dimerization of helical foldamers to control tetrameric avidin proteins.

Design, Synthesis, and Biological Evaluation of New Selective PDE4 Inhibitors for Topical Treatment of Psoriasis.

Psoriasis is a complex and chronic inflammatory disease. Current drugs help control the symptoms of psoriasis but make no cure, urging discovery of novel drugs. We report in this paper the discovery of new phosphodiesterase 4 (PDE4) inhibitors for treatment of psoriasis.

PhosCancer: A comprehensive database for investigating protein phosphorylation in human cancer.

Protein phosphorylation is a crucial post-translational modification implicated in cancer pathogenesis, offering potential diagnostic and therapeutic targets. Here, we developed PhosCancer, a user-friendly database for extracting biologically and clinically relevant insights from phosphoproteomics data. Leveraging data from the CNHPP and CPTAC, PhosCancer encompasses 174,587 phosphosites from 14 datasets spanning 12 cancer types.

B105-8, a potential and efficient biocontrol agent in control of maize stalk rot caused by .

Introduction: Maize stalk rot (MSR), caused by , is the most serious soil borne disease in maize production, seriously affecting maize yield and quality worldwide. Microbial biocontrol agents are the best means of controlling MSR and reducing the use of chemical fungicides, such as spp.

Methods And Results: In the study, a soil-isolated strain B105-8 was identified as (accession No.

flavonoid derivative induces mitochondrial apoptosis in human hepatoma cells through Bclaf1.

4',5,7-Trihydroxy-8-methoxyflavone is an anticancer monomer component isolated from the traditional Chinese medicine . 4',5-Dihydroxy-7-piperazinemethoxy-8-methoxy flavonoids (DMF) with good solubility and anti-tumor effects was obtained by chemical modification in the early stage. This study explored the mechanism by which DMF regulates the mitochondrial apoptosis of human hepatoma cells through Bcl-2-associated transcription factor 1 (Bclaf1).