Global disease burden of breast cancer attributable to high fasting plasma glucose: a comprehensive analysis from the global burden of disease study.

Background: High fasting plasma glucose (HFPG) has been identified as one of the risk factors associated with the development of breast cancer. The worldwide distribution of breast cancer attributable to HFPG was not comprehensively investigated.

Methods: We utilized the data from the Global Burden of Disease Study 2021 to explore HFPG-related breast cancer deaths, disability adjusted life years (DALYs) and corresponding age-standardized rates (ASRs).

The Acute Toxicity and Cardiotoxic Effects of Levofloxacin on Zebrafish ().

Emerging contaminants refer to chemical substances that have not been widely regulated but possess the potential to cause adverse effects on both the environment and human health. Antibiotics, as emerging contaminants, pose significant threats to ecosystems and human health due to their widespread use and persistence in the environment. Levofloxacin, a broad-spectrum fluoroquinolone antibiotic, is commonly employed in the treatment of bacterial infections, and has been frequently detected in environmental matrices and freshwater systems.

Effect of the anatomical patterns of maxillary sinus floor on the endodontic microsurgery plan of maxillary sinusitis of endodontic origin.

Background: Due to the close relationship between maxillary posterior teeth and maxillary sinus floor (MSF), infection from teeth with endodontic disease may spread into maxillary sinus and cause the occurrence of maxillary sinusitis of endodontic origin (MSEO). Endodontic microsurgical intervention in infected teeth causing MSEO requires careful assessment and planning. This study evaluated the anatomical patterns of MSF using cone-beam computed tomography (CBCT), and further explored their influence on the endodontic microsurgery of MSEO.

16S rRNA sequencing reveals relationships among enrichment of oral microbiota in the lower respiratory tract and pulmonary nodules malignant progression.

Unlabelled: Micro-aspiration of oral microorganisms results in considerable enrichment within the lower respiratory tract (LRT), constituting an early event in lung cancer pathogenesis. To explore the correlation between malignant risk of pulmonary nodules (PNs) and oral commensals enrichment in LRT, oral saliva and bronchial alveolar lavage fluid samples from 22 low-risk PN patients, 17 intermediate-risk PN patients, and 11 high-risk PN patients were analyzed using 16S rRNA gene sequencing. Alpha and beta diversity analyses reveal minimal variation in oral microbial diversity and abundance among patients with different risks of PN.

Exploring the effects of Tianma Gouteng granules on L-NAME-induced hypertensive rats based on 16S rDNA gene sequencing and metabolomics.

Background: A growing number of studies have shown that hypertension symptoms are closely related to intestinal flora. The body's metabolites are closely related to disease states. Gouteng Granules (TG), a traditional Chinese medicine compound, has been proven to be an effective compound for the treatment of hypertension by traditional Chinese medicine diagnosis, but the target and therapeutic mechanism of TG on hypertension are still unclear.

A platform combining automatic segmentation and automatic measurement of the maxillary sinus and adjacent structures.

Objectives: To develop a platform including a deep convolutional neural network (DCNN) for automatic segmentation of the maxillary sinus (MS) and adjacent structures, and automatic algorithms for measuring 3-dimensional (3D) clinical parameters.

Materials And Methods: 175 CBCTs containing 242 MS were used as the training, validating and testing datasets at the ratio of 7:1:2. The datasets contained healthy MS and MS with mild (2-4 mm), moderate (4-10 mm) and severe (10- mm) mucosal thickening.

Traditional Chinese exercises for the treatment of neuropsychiatric symptoms in Parkinson's disease: A systematic review and meta-analysis.

Objective: To systematically evaluate the efficacy of traditional Chinese exercises (TCEs) for neuropsychiatric symptoms (NPSs) in patients with Parkinson's disease.

Methods: A comprehensive literature search was performed across eight databases, including PubMed, Cochrane Library, Embase, Web of Science (WoS), SinoMed, China National Knowledge Infrastructure (CNKI), China Science and Technology Periodical Database (VIP), and Wanfang Database, covering studies published from their inception up to April 23, 2024. The search focused on identifying randomized controlled trials (RCTs) assessing the effectiveness of TCEs for NPSs in PD patients.

Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy.

Long-term potentiation (LTP) and long-term depression (LTD) are widely used to study synaptic plasticity. However, whether proteins regulating LTP and LTD are altered in cognitive disorders and contribute to disease onset remains to be determined. Herein, we induced LTP and LTD in the hippocampal CA3-CA1 Schaffer collateral pathway, respectively, and then performed proteomic analysis of the CA1 region.

Response of wastewater treatment performance and bacterial community to original and aged polyvinyl chloride microplastics in sequencing batch reactors.

Microplastics (MPs) are prevalent in wastewater treatment systems, and their behavior is further complicated after undergoing aging processes. This study explored the impact of original and aged polyvinyl chloride (PVC) MPs on wastewater treatment performance and bacterial communities. Results revealed that Fenton-aging treatment induced surface roughening of the MPs and altered their chemical properties.

Optimization of γ-Aminobutyric Acid Production in Brown Rice via Prolonged Seed Priming.

Germinated whole seeds possess elevated levels of bioactive nutrients; however, their application is hindered by several constraints. The germination process is typically time-consuming, and germinated seeds present challenges in terms of storage and transportation compared to dry seeds. This study introduces a novel processing method for rice, termed prolonged priming (PLP), aiming to combine the benefits of germinated and dry seeds.

Oral microbiota as a biomarker for predicting the risk of malignancy in indeterminate pulmonary nodules: a prospective multicenter study.

Background: Determining the benign or malignant status of indeterminate pulmonary nodules (IPN) with intermediate malignancy risk is a significant clinical challenge. Oral microbiota-lung cancer (LC) interactions have qualified oral microbiota as a promising non-invasive predictive biomarker in IPN.

Materials And Methods: Prospectively collected saliva, throat swabs, and tongue coating samples from 1040 IPN patients and 70 healthy controls across three hospitals.

Convolutional neural network-assisted Raman spectroscopy for high-precision diagnosis of glioblastoma.

Glioblastoma multiforme (GBM) is the most lethal intracranial tumor with a median survival of approximately 15 months. Due to its highly invasive properties, it is particularly difficult to accurately identify the tumor margins intraoperatively. The current gold standard for diagnosing GBM during surgery is pathology, but it is time-consuming.

Diagnostic potential of salivary microbiota in persistent pulmonary nodules: identifying biomarkers and functional pathways using 16S rRNA sequencing and machine learning.

Background: The aim of this study was to explore the microbial variations and biomarkers in the oral environment of patients with persistent pulmonary nodules (pPNs) and to reveal the potential biological functions of the salivary microbiota in pPNs.

Materials And Methods: This study included a total of 483 participants (141 healthy controls and 342 patients with pPNs) from June 2022 and January 2024. Saliva samples were subjected to sequencing of the V3-V4 region of the 16S rRNA gene to assess microbial diversity and differential abundance.

Calculation of Fringe Angle with Enhanced Phase Sensitivity and 3D Reconstruction.

In the field of fringe projection profilometry, phase sensitivity is a critical factor influencing the precision of object measurements. Traditional techniques that employ basic horizontal or vertical fringe projection often do not achieve optimal levels of phase sensitivity. The identification of the fringe angle that exhibits optimal phase sensitivity has been a significant area of research.

New Frontiers in phosphorothioate formation: harnessing inorganic phosphorus sources.

Organic phosphorothioates are a class of organic compounds containing the C-S-P structural motif, known for their unique physical and chemical properties. These compounds hold significant value in various fields, including agriculture, pharmaceuticals, and materials science, particularly playing a crucial role in agrochemicals and nucleotide modification. Traditionally, phosphorothioates have been synthesized primarily through the formation of P-S bonds or direct phosphorothioation reactions from organic phosphorus sources such as P(O)H and P(O)SH.

Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung adenocarcinoma.

Background: Radiographically, ground-glass nodules (GGN) and part-solid nodules (PSN) in lung adenocarcinoma (LUAD) have significant heterogeneity in their clinical manifestations, biological characteristics, and prognosis. This study aimed to explore the heterogeneity of LUAD in different radiological phenotypes and associated factors influencing tumor evolution.

Methods: We performed single-cell RNA sequencing (scRNA-seq) on tumor tissues from eight and seven cases of GGN- and PSN-LUAD, respectively, at different disease stages, including minimally invasive adenocarcinoma (MIA), invasive adenocarcinoma (IAC), and metastatic lung cancer (MLC).

ICAM1 and VCAM1 are associated with outcome in patients with sepsis: A systematic review and meta-analysis.

Background: Endothelial cell dysfunction and microcirculatory disturbances play crucial roles in the pathogenesis of sepsis. This systematic review and meta-analysis explored the relationship of the plasma levels of the key endothelial proteins intercellular adhesion molecule 1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1) with clinical outcomes in patients with sepsis.

Methods: MEDLINE and EMBASE were searched through November 28, 2023.

Trans-arterial chemo-emobilization (TACE) combined with laparoscopic portal vein ligation and terminal branches portal vein embolization for hepatocellular carcinoma: a novel conversion strategy.

Background: Hepatocellular carcinoma (HCC) is currently one of the most common malignant tumors with the highest mortality rates in the world. Most patients with HCC have lost the opportunity for surgery at the time of initial diagnosis. This study aims to introduce a new conversion strategy: trans-arterial chemo-emobilization (TACE) combined with laparoscopic portal vein ligation (PVL) and terminal branches portal vein embolization (PVE).

Accurate and efficient prediction of atmospheric PM, PM, PM, and O concentrations using a customized software package based on a machine-learning algorithm.

Particulate matter (PM) and ozone (O) pollution have been attracting increasing attention recently due to their severe harm to human health. PM and O are secondary pollutants, and there remain significant challenges in accurately and efficiently predicting their concentrations in the atmosphere. In this study, one-year monitoring data of PM, PM, PM, and O concentrations as well as meteorological parameters and concentrations of various precursors (i.

Recombinant MS087-based indirect ELISA for the diagnosis of .

Accurate detection is a prerequisite for effective prevention and control of infection. ELISA is the most popular method for the clinical detection of because of its convenience, low cost, and high detection rate. However, the cross-reactivity of commercially available ELISA kits with other avian pathogen-positive sera needs to be addressed.

Evaluation of the Choroid Plexus Epithelium Inflammation TLR4/NF-κB/NKCC1 Signal Pathway Activation in the Development of Hydrocephalus.

Background: Hydrocephalus is characterized by secretion, circulation, and absorption disorder of cerebrospinal fluid (CSF) with high morbidity and complication rate. The relationship between inflammation and abnormal secretion of CSF by choroid plexus epithelium (CPE) had received more attention. In this study, we aim to detect the role of Toll-like receptor 4/nuclear factor-kappa B/Na+/K+/2Cl-cotransporter 1(TLR4/NF-κB/NKCC1) signal pathway in the development of hydrocephalus.

Global, reginal, national burden and risk factors in female breast cancer from 1990 to 2021.

This study was to assess the burden, trends, and risk factors associated with female breast cancer from 1990 to 2021 based on the Global Burden of Disease (GBD) 2021 study. In 2021, there were 20.32 million prevalent cases, 2.