On-site biosignal amplification using a single high-spin conjugated polymer.

On-site or in-sensor biosignal transduction and amplification can offer several benefits such as improved signal quality, reduced redundant data transmission, and enhanced system integration. Ambipolar organic electrochemical transistors (OECTs) are promising for this purpose due to their high transconductance, low operating voltage, biocompatibility, and suitability for miniaturized amplifier design. However, limitations in material performance and stability have hindered their application in biosignal amplification.

The in vitro elution characteristics of vancomycin from the ligament augmentation and reconstruction system.

Purpose: In this study, we aimed to characterize the elution profile of the ligament augmentation and reconstruction system (LARS) immersed in different concentrations of vancomycin using different immersion methods and determine whether the amount of vancomycin released was lower than the toxic concentrations for osteoblasts and chondroblasts.

Methods: The LARS was presoaked with 5, 2.5 or 1.

Periodontal bacteria influence systemic diseases through the gut microbiota.

Many systemic diseases, including Alzheimer disease (AD), diabetes mellitus (DM) and cardiovascular disease, are associated with microbiota dysbiosis. The oral and intestinal microbiota are directly connected anatomically, and communicate with each other through the oral-gut microbiome axis to establish and maintain host microbial homeostasis. In addition to directly, periodontal bacteria may also be indirectly involved in the regulation of systemic health and disease through the disturbed gut.

High-efficiency 2.3 µm Tm:YLF laser based on 0.79 µm and 1.05 µm dual-wavelength pumping scheme.

A high-efficiency Tm:YLF laser at 2.3 µm is demonstrated based on a dual-wavelength pumping scheme with 790 nm LD and a tunable Yb:CALGO laser at around 1.05 µm.

LnCeCell 2.0: an updated resource for lncRNA-associated ceRNA networks and web tools based on single-cell and spatial transcriptomics sequencing data.

We describe LnCeCell 2.0 (http://bio-bigdata.hrbmu.

Progression of aortic calcification among Japanese in Japan and white and Japanese Americans: a prospective cohort study.

Aims: Continued low mortality from coronary heart disease in Japan, despite deleterious changes in traditional risk factors, remains unexplained. Since aortic calcification (AC) was an early predictor of cardiovascular mortality, we compared the progression and incidence of AC between Japanese in Japan, white Americans, and third-generation Japanese Americans in the ERA JUMP cohort. We examined whether higher blood levels of marine-derived n-3 fatty acids (FAs) in Japanese than in Americans accounted for the difference.

Characterization of the Biological Variability of the Angiome Biomarkers over Time in Healthy Subjects.

Background: Biomarker analyses are an integral part of cancer research. Despite the intense efforts to identify and characterize biomarkers in cancer patients, little is known regarding the natural variation of biomarkers in healthy populations. Here we conducted a clinical study to evaluate the natural variability of biomarkers over time in healthy participants.

Prediction of preoperative lymph-vascular space invasion and survival outcomes of cervical squamous cell carcinoma by utilizing 18 F-FDG PET/CT imaging at early stage.

Objective: To establish nomograms for predicting preoperative lymph-vascular space invasion (LVSI) and survival outcomes of cervical squamous cell carcinoma (CSCC) based on PET/CT radiomics.

Methods: One hundred and twenty-three patients with CSCC and LVSI status were enrolled retrospectively. Independent predictors of LVSI were identified through clinicopathological factors and PET/CT metabolic parameters.

Machine learning model predicting factors for incisional infection following right hemicolectomy for colon cancer.

Background And Aim: Colorectal cancer is a prevalent malignancy worldwide, and right hemicolectomy is a common surgical procedure for its treatment. However, postoperative incisional infections remain a significant complication, leading to prolonged hospital stays, increased healthcare costs, and patient discomfort. Therefore, this study aims to utilize machine learning models, including random forest, support vector machine, deep learning models, and traditional logistic regression, to predict factors associated with incisional infection following right hemicolectomy for colon cancer.

Allelic variations of HMW-GS and LMW-GS and quality analysis in Yannong series wheat cultivars/derivative lines.

Introduction: Gluten quality is one of the most important traits of the common wheat ( L.). In Chinese wheat production, Yannong series cultivars/derivative lines possess unique characteristics and play an important role in both yield and quality contribution.

Unusual Cross-Conjugation in Cyclic Dipeptide-Based Building Blocks for Donor-Acceptor Semiconducting Conjugated Polymers.

Cross conjugation, though prevalent in many organic compounds, is typically considered less effective for electron delocalization compared to linear conjugation. Consequently, it is rarely used as the backbone structure for semiconducting conjugated polymers. In this study, we designed and synthesized a novel building block, TIDP, which features a central cyclic dipeptide with cross conjugation characteristics.

Global research development of chondrosarcoma from 2003 to 2022: a bibliometric analysis.

Background: Chondrosarcomas are common primary malignant bone tumors; however, comprehensive bibliometric analysis in this field has not yet been conducted. Therefore, this study aimed to explore the research hotspots and trends in the field of chondrosarcoma through bibliometric analysis to help researchers understand the current status and direction of research in the field.

Methods: Articles and reviews related to chondrosarcoma published between 2003 and 2022 were retrieved from the Web of Science.

FBXO22 promotes osteosarcoma progression via regulation of FOXO1 for ubiquitination and degradation.

Accumulating evidence has demonstrated that F-box protein 22 (FBXO22) participates in tumour development and progression in various types of human malignancies. However, the functions and detailed molecular mechanisms of FBXO22 in osteosarcoma tumorigenesis and progression remain elusive. In this study, we aimed to determine the effects of FBXO22 on the cell proliferation, migration and invasion of osteosarcoma cells using cell counting kit-8 and Matrigel Transwell approaches.

Heteroaryl Group Containing Trisubstituted Alkenes: Synthesis and Anti-Tumor Activity.

Pancreatobililary cancers are fatal solid tumors that pose a significant threat to human life. It is imperative to investigate novel small molecule active compounds for controlling these cancers. Heterocyclic compounds (e.

Boron-Doped Dinickel Phosphide to Enhance Polysulfide Conversion and Suppress Shuttling in Lithium-Sulfur Batteries.

Lithium-sulfur (Li-S) batteries are promising for next-generation high-energy energy storage systems. However, the slow reaction kinetics render mobile polysulfides hardly controlled, yielding shuttling effects and eventually damaging Li metal anodes. To improve the cyclability of Li-S batteries, high-efficiency catalysts are desired to accelerate polysulfide conversion and suppress the shuttling effect.

V-Doped CoSe Nanowire Catalysts in a 3D-Structured Electrode for Durable Li-S Pouch Cells.

Lithium-sulfur (Li-S) batteries have high theoretical energy density and are regarded as a promising candidate for next-generation energy storage systems. However, their practical applications are hindered by the slow kinetics of sulfur conversion and polysulfide shuttling. In particular, large-scale pouch cells show much poor cyclability.

Risk factors for the recurrence of left atrioventricular valvular regurgitation after surgical repair of partial and transitional atrioventricular septal defect.

Background: Left atrioventricular valvular regurgitation (LAVVR) recurrence after partial and transitional atrioventricular septal defect (AVSD) repair is the main risk factor associated with reoperation or mortality. The purpose of this study was to identify risk factors associated with the recurrence of LAVVR after surgical repair of transitional and partial AVSD at a single institution.

Methods: A hundred and fifty-seven patients who underwent anatomical repair for partial and transitional AVSD from January 2013 to December 2021 were included in our institutional database.

Quantum randomness introduced through squeezing operations and random number generation.

Quantum random numbers play a crucial role in diverse applications, including cryptography, simulation, and artificial intelligence. In contrast to predictable algorithm-based pseudo-random numbers, quantum physics provides new avenues for generating theoretically true random numbers by exploiting the inherent uncertainty contained in quantum phenomena. Here, we propose and demonstrate a quantum random number generator (QRNG) using a prepared broadband squeezed state of light, where the randomness of the generated numbers entirely originates from the quantum noise introduced by squeezing operation rather than vacuum noise.

4.1 W continuous-wave and broadly wavelength tunable Tm-doped laser in 2.1-2.4 µm spectral region based on vibronic and electronic transitions.

Efficient diode-pumped continuous-wave (CW) and wavelength tunable Tm:YAP lasers based on the vibronic and electronic transitions are investigated. A total maximum output power of 4.1 W is achieved with multi-wavelength output around 2162 nm and 2274 nm, corresponding to a slope efficiency of 29.

Bulked segregant RNA-seq reveals complex resistance expression profile to powdery mildew in wild emmer wheat W762.

Powdery mildew, caused by f. sp. (), is one of the most destructive fungal diseases threatening global wheat production.

Effects of polypropylene films and leached dissolved organic matters on bacterial community structure in mangrove sediments.

Over the past decades, the accumulation of plastics in mangrove ecosystems has emerged as a significant environmental concern, primarily due to anthropogenic activities. Polypropylene (PP) films, one of the plastic types with the highest detection rate, tend to undergo intricate aging processes in mangrove ecosystems, leading to the release of dissolved organic matter (DOM) that may further influence the local bacterial communities. Yet, the specific effects of new and weathered (aged) plastic films and the associated leached DOM on bacterial consortia in mangrove sediments remain poorly understood.

High-Speed Quantum Radio-Frequency-Over-Light Communication.

Quantum dense coding (QDC) means to transmit two classical bits by only transferring one quantum bit, which has enabled high-capacity information transmission and strengthened system security. Continuous-variable QDC offers a promising solution to increase communication rates while achieving seamless integration with classical communication systems. Here, we propose and experimentally demonstrate a high-speed quantum radio-frequency-over-light (RFOL) communication scheme based on QDC with an entangled state, and achieve a practical rate of 20 Mbps through digital modulation and RFOL communication.