Correlation analysis between micro and macro indicators of high modulus modified asphalt for asphalt pavement.

The relationship between the micro technical indexes and the macro road performance of high modulus asphalt (HMA) is helpful for understanding its mechanism and performance, and promoting its application. To explore the relationship, two kinds of high modulus asphalt (HMA), LLDPE/SBS composite modified asphalt and rubber/PPA composite modified asphalt were prepared according to the HMA requirements. Secondly, Molecular models of two kinds of HMA were established through molecular dynamics (MD) simulations, and the high temperature parameters of LLDPE/SBS composite modified asphalt were obtained with the two methods, namely the micro molecular dynamics simulation and high temperature rheological test, respectively.

Vascular volume changes in radiological patterns of usual interstitial pneumonia in patients with type 2 diabetes.

Objective: This research primarily focuses on exploring the changes in intrapulmonary vascular volume (IPVV) in radiological patterns of usual interstitial pneumonia (UIP) associated with Type 2 Diabetes Mellitus (T2DM), thereby inferring the possible mechanisms of the co-occurrence of diabetes and UIP patterns.

Methods: Thin-layer data were post-processed on the basis of high-resolution computed tomography (HRCT) and quantitatively assessed for IPVV. Changes in IPVV were compared between T2DM combined with UIP modality and T2DM non-UIP modality.

Construction of Photothermal Intelligent Membranes for Point-of-Use Water Treatment.

For the removal of waterborne pathogens in remote areas and disaster emergency situations, point-source water treatment methods are more suitable. Photothermal sterilization is ideal for point-of-use (POU) systems, as it effectively eliminates pathogens without secondary pollution or bacterial resistance issues. By combining photothermal with membrane treatment, these membranes rapidly heat up under near-infrared (NIR) light, enabling both bacterial retention and sterilization.

Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MiR-744-5p Alleviates Obstructive Sleep Apnea-Induced Myocardial Injury by Targeting NFIX.

Obstructive sleep apnea (OSA) is characterized by repetitive pharyngeal collapses during sleep, which leads to intermittent hypoxia, a risk factor of OSA-related cardiovascular morbidity.In this work, exosome isolation and identification with ultracentrifugation, transmission electron microscopy, nanoparticle tracking analysis, and Western blot assay were carried out. H9C2 cells were subjected to chronic intermittent hypoxia (CIH) treatment, which was followed by bone marrow mesenchymal stem cell (BMSC) -derived exosome treatment.

Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival.

Proper control of inflammatory responses is essential for embryonic development, but the underlying mechanism is poorly understood. Here, we show that under physiological conditions, inactivation of ISG15, an inflammation amplifier, is associated with the interaction of Beclin 1 (Becn1), via its ECD domain, with STAT3 in the major fetal hematopoietic organ of mice. Conditional loss of Becn1 caused sequential dysfunction and exhaustion of fetal liver hematopoietic stem cells, leading to lethal inflammatory cell-biased hematopoiesis in the fetus.

Adapted evolution towards flagellar loss in Pseudomonas syringae.

The flagellum is a complex molecular nanomachine crucial for cell motility. Its assembly requires coordinated expression of over 50 flagellar genes, regulated by the transcription activator FleQ. Phylogenomic analyses suggest that many non-flagellated bacterial species have evolved from flagellated ancestors by losing specific flagellar components, though the evolutionary mechanisms driving this process remain unclear.

Associations between volatile organic compounds exposure and multiple oxidative damage biomarkers: Method development, human exposure, and application for e-waste pollution prediction.

Atmospheric monitoring studies reveal substantial health risks from exposure to volatile organic compounds (VOCs) for workers and nearby children in e-waste recycling areas (ERA), yet internal exposure risks are seldom examined. To address this, we developed a method to simultaneously analyze 12 urinary VOC metabolites (mVOCs) and oxidative damage biomarkers (ODBs) in workers and children from ERA and general adults from control areas using ultrahigh performance liquid chromatography coupled with quadrupole/orbitrap high-resolution mass spectrometry (UPLC-Orbitrap-HRMS). The results showed that e-waste workers exhibited significantly higher levels of VOC exposure and ODBs than e-waste children and control adults.

Full van der Waals Ambipolar Ferroelectric Configurable Optical Hetero-Synapses for In-Sensor Computing.

The rapid development of visual neuromorphic hardware can be attributed to their ability to capture, store and process optical signals from the environment. The main limitation of existing visual neuromorphic hardware is that the realization of complex functions is premised on the increase of manufacturing cost, hardware volume and energy consumption. In this study, we demonstrated an optical synaptic device based on a three-terminal van der Waals (vdW) heterojunction that can realize the sensing functions of light wavelength and intensity as well as short-term and long-term synaptic plasticity.

Hypertension-Induced Biomechanical Modifications in the Aortic Wall and Their Role in Stanford Type B Aortic Dissection.

Objective: Hypertension is a major risk factor for the type B aortic dissection (TBAD), while many patients do not manage or regulate their hypertension consistently, leading to stable or unstable hypertension. Currently, the effects of stable and unstable hypertension on the biomechanical properties of the aorta remain unclear. The objective was to identify a blood pressure state that represents a greater risk for TBAD development.

Predictive value of geriatric nutritional risk index in cardiac and cerebrovascular events after endovascular aortic aneurysm repair.

Objective: To evaluate the effect of malnutrition assessed by the Geriatric Nutritional Risk Index (GNRI) on major adverse cardiac and cerebrovascular events (MACCE) in the elderly patients after endovascular aortic aneurysm repair (EVAR).

Materials And Methods: This was a retrospective cohort study of elderly patients who underwent EVAR in a tertiary hospital. Malnutrition status was assessed by the GNRI.

Dual modification of the aggregation behavior and in vitro digestion of oxidized pine kernel protein via a combination of homogenization and succinylation.

Protein oxidation affects the high-value utilization of nuts as oxidative attack causes protein aggregation, thereby challenging their technological functionality. Herein, a strategy using homogenization-assisted octenyl succinic anhydride (OSA) modification was proposed to tailor the structure, aggregation behavior, and digestive characteristics of oxidized pine kernel proteins. Results indicated that the ratio of α-helices to β-turns ranged from as low as 0.

The Impact of Starting Positions and Breathing Rhythms on Cardiopulmonary Stress and Post-Exercise Oxygen Consumption after High-Intensity Metabolic Training: A Randomized Crossover Prospective Study.

The exploration of optimizing cardiopulmonary function and athletic performance through high-intensity metabolic exercises (HIMEs) is paramount in sports science. Despite the acknowledged efficacy of HIMEs in enhancing cardiopulmonary endurance, the high metabolic stress imposed on the cardiopulmonary system, especially for amateurs, necessitates a scaled approach to training. : The aim of this study is to ascertain whether adjustments in the initiation posture and the adoption of an appropriate breathing strategy can effectively mitigate the cardiopulmonary stress induced by HIMEs without compromising training efficacy.

Revealing the links between hair metal(loids) and alterations in blood pressure among children in e-waste recycling areas through urinary metabolomics.

Hypertension is prevalent in e-waste recycling areas, and elevated blood pressure in children significantly increases the risk of hypertension in adulthood. However, the associations and toxic pathways between chronic exposure to metal(loids) and elevated blood pressure are rarely investigated. In this study, we measured the levels of 29 hair metal(loids) (chronic exposure biomarkers) and blood pressure in 667 susceptible children from an e-waste recycling area to explore their relationships.

Uncovering quality changes of shrimp () during solar drying and its relationship with protein-related properties.

This study explored the intrinsic relationship between the quality traits and protein-related property changes during the solar drying of shrimps (). During drying, the shrimp exhibited a gradual decline in *** values and a notable increase in the hardness and chewiness. Proteins were degraded and oxidized.

Safety and efficacy of drug-eluting stents versus heparin-bonded stents in treatment of femoropopliteal peripheral artery disease: study protocol for a multicentre, prospective randomised controlled trial in China (ELITE trial).

Introduction: Endovascular therapy has emerged as a prominent strategy for managing femoropopliteal peripheral artery disease, offering acceptable safety and efficacy compared with open surgical bypass. Both paclitaxel-eluting stents and heparin-bonded covered stents have exhibited enhanced clinical outcomes compared with bare metal stents. However, there is currently a lack of level I evidence comparing the safety and efficacy of paclitaxel-eluting stents and heparin-bonded covered stents.

Bottom Contact Engineering for Ambient Fabrication of >25% Durable Perovskite Solar Cells.

The bottom contact in perovskite solar cells (PSCs) is easy to cause deep trap states and severe instability issues, especially under maximum power point tracking (MPPT). In this study, sodium gluconate (SG) is employed to disperse tin oxide (SnO) nanoparticles (NPs) and regulate the interface contact at the buried interface. The SG-SnO electron transfer layer (ETL) enabled the deposition of pinhole-free perovskite films in ambient air and improved interface contact by bridging effect.

Development and Validation of a User Friendly Morphology Grading System (PATENT) Predicting Aortic Remodelling After Thoracic Endovascular Aortic Repair in High Risk Uncomplicated Type B Aortic Dissection.

Objective: This study aimed to create a morphology grading system, solely based on 2D images from computed tomography angiography, to predict negative aortic remodelling (NAR) for patients with high risk uncomplicated type B aortic dissection (TBAD) after thoracic endovascular aortic repair (TEVAR).

Methods: This single centre retrospective cohort study extracted and analysed consecutive patients diagnosed with high risk uncomplicated TBAD. Negative aortic remodelling was defined as an increase in the false lumen or total aortic diameter, or decrease in the true lumen diameter.

Enhance Carrier Diffusion of Monolayer MoSe by Interface Engineering.

Two-dimensional materials hold great potentials for beyond-CMOS (complementary metal-oxide-semiconductor) electronical and optoelectrical applications, and the development of field effect transistors (FET) with excellent performance using such materials is of particular interest. How to improve the performance of devices thus becomes an urgent issue. The performance of FETs depends greatly on the intrinsic electrical properties of the channel materials, meanwhile the device interface quality, such as extrinsic scattering of charged impurities, charge traps, and substrate surface roughness have a great influence on the performance.

Research Progress of Single-Photon Emitters Based on Two-Dimensional Materials.

From quantum communications to quantum computing, single-photon emitters (SPEs) are essential components of numerous quantum technologies. Two-dimensional (2D) materials have especially been found to be highly attractive for the research into nanoscale light-matter interactions. In particular, localized photonic states at their surfaces have attracted great attention due to their enormous potential applications in quantum optics.

Study on the extraction, purification, stability, free radical scavenging kinetics, polymerization degree and characterization of proanthocyanidins from Pinus koraiensis seed scales.

To efficiently harness resources from Pinus koraiensis seed scales, a type of forestry waste, rigorous studies on the extraction, purification, stability, and free radical scavenging capacity of the proanthocyanidins derived from these seed scales were conducted. Kinetic models showed that under ultrasonic conditions, the proanthocyanidins content reached 2.66 mg/g within 0.

Neural Correlate and Movement Decoding of Simultaneous-and-Sequential Bimanual Movements Using EEG Signals.

Bimanual coordination is important for developing a natural motor brain-computer interface (BCI) from electroencephalogram (EEG) signals, covering the aspects of bilateral arm training for rehabilitation, bimanual coordination for daily-life assistance, and also improving the multidimensional control of BCIs. For the same task targets of both hands, simultaneous and sequential bimanual movements are two different bimanual coordination manners. Planning and performing motor sequences are the fundamental abilities of humans, and it is more natural to execute sequential movements compared to simultaneous movements in many complex tasks.

A Visual-Inertial Pressure Fusion-Based Underwater Simultaneous Localization and Mapping System.

Detecting objects, particularly naval mines, on the seafloor is a complex task. In naval mine countermeasures (MCM) operations, sidescan or synthetic aperture sonars have been used to search large areas. However, a single sensor cannot meet the requirements of high-precision autonomous navigation.