Single-Cell RNA Sequencing Reveals Peripheral Immune Cell Senescence and Inflammatory Phenotypes in Patients with Premature Ovarian Failure.

Background: Premature Ovarian Failure (POF) is a heterogeneous syndrome characterized by ovarian dysfunction, frequently associated with autoimmune factors. The interaction between peripheral and ovarian immune signals remains unclear. Recent advancements in single-cell technology provide a unique opportunity to examine the complex peripheral immune response in POF patients at the microstructural level.

A bacterial RING ubiquitin ligase triggering stepwise degradation of BRISC via TOLLIP-mediated selective autophagy manipulates host inflammatory response.

Numerous bacterial pathogens have evolved tactics to interfere with the host ubiquitination network to evade clearance by the innate immune system. Nevertheless, the subtle antagonism between a bacterial ubiquitinase and a host deubiquitinase, through which they modify their respective targets within a multifaceted network, has yet to be characterized. BRCC3 isopeptidase complex (BRISC) is a newly identified K63-specific deubiquitinase complex that plays a crucial role in cellular signaling pathways such as inflammation.

[Multi-scenario Simulation and Eco-environmental Effect Analysis of Production-Living-Ecological Space in Henan Province Based on PLUS Model].

Considering Henan Province as the research area, based on land use data with a resolution of 30 m in 2000, 2010, and 2020, we analyzed the distribution of the production-living-ecological space and the quality of the ecological environment in Henan Province using land transfer matrices and an eco-environmental effect model. Furthermore, based on 2020 land use data, the PLUS model was used to simulate land use data for the years 2030, 2040, and 2050 under three scenarios： natural development, production priority, and ecological priority. Finally, we calculated the ecological environment quality index and ecological contribution rate.

Above-Curie-temperature ultrafast terahertz emission and spin current generation in a 2D superlattice (FeGeTe/CrSb).

The increasing demand for denser information storage and faster data processing has fueled a keen interest in exploring spin currents up to terahertz (THz) frequencies. Emergent 2D intrinsic magnetic materials constitute a novel and highly controllable platform to access such femtosecond spin dynamics at atomic layer thickness. However, the function of 2D van der Waals magnets are limited by their Curie temperatures, which are usually low.

Tidal-driven NO emission is a stronger resister than CH to offset annual carbon sequestration in mangrove ecosystems.

The mangrove ecosystems store a significant amount of "blue carbon" to mitigate global climate change, but also serve as hotspots for greenhouse gases (GHGs: CO, CH and NO) production. The CH and NO emissions offset mangrove carbon benefits, however, the extent of this effect remains inadequately quantified. By applying the 36 h time-series observations and mapping cruises, here we investigated the spatial and temporal distribution of GHGs and their fluxes in Dongzhaigang (DZG) bay, the largest mangrove ecosystem in China, at tidal and monthly scales.

Antagonistic interaction between miR-143 and KRAS gene regulating male mouse germ cell apoptosis.

Precisely regulated spermatocyte growth, differentiation, and apoptosis are crucial for sustainable male fertility. miR-143 has been demonstrated to regulate gene expression and cell apoptosis in various human cancers. However, the function of mmu-mir-143 (miR-143) in mammalian testes and its underlying mechanism remains unexplored.

Synthesis of 2,7-Dihydrooxepine-spirodithiophene Derivatives via an Intramolecular Ring Closure Reaction.

Spiro architectures with π-conjugation have improved thermal stability and stronger photosensitivity, making them potentially useful for organic optoelectronic devices. Our recent work has demonstrated the synthetic chemistry of a novel thiophene oligomer combining 2,7-dihydrooxepine and dispiro structure and derived it into A-D-A-type compounds. The optical spectroscopy and electrochemical characteristics were investigated.

Alkane degradation coupled to Fe(III) reduction mediated by Gram-positive bacteria.

Petroleum hydrocarbon contamination, such as n-alkanes, poses a significant global threat to ecosystems and human health. Microbial remediation emerges as a promising strategy for addressing this issue through both aerobic and anaerobic processes. Notably, the majority of anaerobic hydrocarbon degraders identified to date are Gram-negative bacteria.

Manipulating Magnetic Damping of Fe/GeTe Heterostructures by Band Engineering.

Understanding and manipulating magnetic damping, particularly in magnetic heterostructures, is crucial for fundamental research, versatile engineering, and optimization. Although magnetic damping can be enhanced by the band hybridization between ferromagnetic and nonmagnetic materials at the interface, the contribution of individual subbands on the hybridized bands to magnetic damping is fully unexplored. Here, it is found that magnetic damping α is modified by the Fermi level in Fe/GeTe heterostructures via Bi doping.

Dose-responsive effects of endothelial cell-sourced exosomes on vascular cell proliferation and phenotype transition.

Endothelial cell-sourced exosomes are potential participants in the process of atherosclerosis, and their function is mainly affected by concentration. By studying the effects of exosome concentrations on vascular cells, atherosclerosis can be better intervened. In this study, exosomes with concentrations of 0, 0.

Global research trends in the teacher evaluation of medical college: A bibliometric and visualized study.

Background: The evaluation of education in colleges and universities is not only an essential means to promote teachers' professional development and ensure high-quality development of education but also a strong support for the overall development of colleges and universities. In this study, to understand the development trends and predict the future of teacher evaluation in medical colleges from 2005 to 2023, we conducted a comprehensive bibliometric and visualized study using Web of Science.

Methods: The articles on teacher evaluation in medical colleges were extracted from the "Core Collection" of the WoS database.

Pathways and enhanced evaluation system for green low-carbon development across diverse Chinese regions.

Background: Rapid economic growth in China has led to significant resource and environmental challenges, particularly in less economically developed regions. This study aims to identify effective strategies for achieving green, low-carbon development in these regions during the economic transition.

Methods: We employed the Fuzzy-Set Qualitative Comparative Analysis (fsQCA) method to scrutinize the impact of economic, demographic, industrial, and technological factors on low-carbon development across a selection of Chinese provinces, including Qinghai, Hunan, Beijing, Shanghai, Tianjin, Hainan, and Chongqing.

The near-complete genome assembly of hexaploid wild oat reveals its genome evolution and divergence with cultivated oats.

Avena sterilis, the ancestral species of cultivated oats, is a valuable genetic resource for oat improvement. Here we generated a near-complete 10.99 Gb A.

A multi-epitope subunit vaccine providing broad cross-protection against diverse serotypes of Streptococcus suis.

Streptococcus suis infection represents a major challenge in pig farming and public health due to its zoonotic potential and diverse serotypes, while existing vaccines lack effective cross-protection. This study employed reverse vaccinology and immunoinformatics to identify 8 conserved proteins across 11 prevalent serotypes of S. suis.

Inhibitory Effect of Phenethyl Isothiocyanate on the Adhesion and Biofilm Formation of and Application on Beef.

This study aimed to explore the mechanism by which phenethyl isothiocyanate (PEITC) inhibited the adhesion and biofilm formation of (). PEITC exhibited antimicrobial efficacy against , demonstrating a minimum inhibition concentration (MIC) of 1 mmol/L. PEITC exerted its antibacterial effect by disrupting cell membrane integrity, and it decreased total adenosine triphosphate (ATP) production after 1 and 4 h treatment.

Carbon Dots and Their Films with Narrow Full Width at Half Maximum Orange Emission.

To obtain carbon dots (CDs) with narrow full width at half maximum (FWHM) and long-wavelength emission, carbon sources with high conjugate sizes and abundant functional groups can be employed to synthesize CDs. In this study, orange-emissive carbon dots (OCDs) were synthesized with phloroglucinol and rhodamine B as precursors. When the molar ratio of them was 30:1, and ethanol was served as the solvent, OCDs with optimized emission wavelength at approximately 580 nm, an FWHM of 30 nm, and a quantum yield (QY) of 27.

Effects of C-S-H Seed Prepared by Wet Grinding on the Properties of Cement Containing Large Amounts of Silica Fume.

This study aimed to utilize the hydration characteristics of cement through wet grinding techniques to efficiently and conveniently prepare a stable C-S-H seed suspension, providing key parameters and a scientific basis for their large-scale production, which ensures the stability of the C-S-H suspension during production, transportation, and application. This preparation aimed to mitigate the adverse effects of high-volume silica fume on the early mechanical properties of high-performance cement concrete. The properties of C-S-H seed were characterized in detail by SEM, XRD, and TD.

Water adsorption on ferroelectric PbTiO (0 0 1) surface: A density functional theory study.

In this work, combining the density functional theory (DFT) calculations and the ab initio molecular dynamics (AIMD) simulations, the water adsorption behavior, including the molecular and the dissociative adsorption on the negatively polarized (0 0 1) surface of ferroelectric PbTiO was comprehensively studied. Our theoretical results show that the dissociative adsorption of water is more energetically favorable than the molecular adsorption on the pristine PbTiO (0 0 1) surface. It has been also found that introducing surface oxygen vacancies (O) can enhance the thermodynamic stability of dissociative adsorption of water molecule.

Surface plasmon resonance effect cooperated with Z-scheme heterostructure for enhancing photocatalytic nitrogen reduction to ammonia.

The photocatalytic efficiency can be improved by constructing a Z-scheme heterojunction, but hindered by the only half utilization efficiency of photogenerated carriers. Thus, a novel material, UiO-66-NH@TAPB-BTCA-COP-Ag (U6N@COP-Ag), with surface plasmon resonance (SPR) effect synergistic Z-scheme heterostructure has been prepared by depositing Ag nanoparticles (Ag NPs) on TAPB-BTCA-COP (COP)-coated UiO-66-NH. The deposited Ag NPs expand the range of light absorption and introduce more photogenerated electrons in the composite.

Explicit Abnormality Extraction for Unsupervised Motion Artifact Reduction in Magnetic Resonance Imaging.

Motion artifacts compromise the quality of magnetic resonance imaging (MRI) and pose challenges to achieving diagnostic outcomes and image-guided therapies. In recent years, supervised deep learning approaches have emerged as successful solutions for motion artifact reduction (MAR). One disadvantage of these methods is their dependency on acquiring paired sets of motion artifact-corrupted (MA-corrupted) and motion artifact-free (MA-free) MR images for training purposes.

Unveiling the dominance of submarine groundwater discharge on nutrient sources in the Eastern China Marginal Seas.

River and atmosphere are traditionally recognized as the primary nutrient sources impacting coastal ecosystems. Despite the increasing attention towards the often-neglected submarine groundwater discharge (SGD), its understanding and significance in highly human-impacted marginal seas remain limited. This study utilizes unprecedented high-resolution data (561 seawater and 282 groundwater radium samples) to provide precise estimates of Ra and Ra sources and sinks in the Eastern China Marginal Seas.