Nanoarchitectonics of High-Performance and Flexible n-Type Organic-Inorganic Composite Thermoelectric Fibers for Wearable Electronics.

Since most conductive polymers are -type, developing high-performance -type organic-inorganic composite thermoelectric (TE) fibers is a great challenge. Herein, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)-coated AgTe nanowires (PC-AgTe NWs) were prepared by a liquid-phase reaction using PEDOT:PSS-coated Te nanowires (PC-Te NWs) as templates, and the PEDOT:PSS/PC-AgTe NWs composite fibers were then prepared by wet spinning. As the content of PC-AgTe NWs increases, the composite fiber changes from -type to -type.

Discovery and Functional Characterization of a Recombinant Fragment of Human Collagen Type XVII.

COL17A1 is predominantly expressed in skin epithelial cells and primarily localized within hemidesmosomes. It plays an essential role in epidermal-dermal attachment. Consequently, a recombinant human-like COL17A1 protein (rhCOL17) with low molecular weight and high biocompatibility presents a promising and competitive biomaterial.

The Expression and Clinical Significance of CCDC12 in the Initial Diagnosis of Acute Myeloid Leukemia.

Background: This study investigated the expression and clinical significance of coiled-coil domain containing 12 (CCDC12) in the initial diagnosis of acute myeloid leukemia (AML).

Methods: A total of 80 AML patients were enrolled as the experimental group, and 20 normal bone marrow specimens were used as the control group. Clinical data of AML patients were collected.

PDCD11 Stabilizes C-MYC Oncoprotein by Hindering C-MYC-SKP2 Negative Feedback Loop to Facilitate Progression of p53-Mutant Breast and Colon Malignancies.

C-MYC is a proto-oncoprotein whose dysregulation triggers tumorigenesis and tumor progression in ≈70% of cancer cases. It is presently demonstrated that aberrantly upregulated MYC is caused by the overexpressed and "extra-nucleolar" PDCD11 in p53-mutant breast and colon cancer cells, which is highly correlated to tumor progression, metastasis, and recurrence. In the nucleoplasm, PDCD11 binds to the TAD of C-MYC to prevent SKP2, a transcriptional target of C-MYC as well as one of the major E3 ligase components targeting C-MYC, from interacting with and ubiquitinating C-MYC in feedback.

MHFNet: A Multimodal Hybrid-embedding Fusion Network for Automatic Sleep Staging.

Scoring sleep stages is essential for evaluating the status of sleep continuity and comprehending its structure. Despite previous attempts, automating sleep scoring remains challenging. First, most existing works did not fuse local and global temporal information.

Design, synthesis and anticancer evaluation of novel 1,3-imidazole-type phenylhistin derivatives: Dual mechanism via P53 induction and microtubulin inhibition.

To enhance biological activity and deepen the understanding of the structure-activity relationship, a systematic study was conducted on the 5-position of the 1,3-imidazol-4-yl group in phenylahistin. The interaction between phenylahistin derivative 16j and the colchicine-binding site was first analyzed in detail, leading to the development of a fragment library to replace the tert-butyl group. A series of 20 novel phenylhistin derivatives were designed, synthesized, and characterized.

[Recent Advances in Diagnosis and Treatment of Diffuse Alveolar Hemorrhage after Hematopoietic Stem Cell Transplantation --Review].

Diffuse alveolar hemorrhage (DAH) is a severe complication that can occur post- hematopoietic stem cell transplantation (HSCT). So far, the precise pathogenesis and risk factors of DAH post-HSCT remain elusive, diagnostic criteria have not reached a consensus, and the efficacy of existing therapeutic measures is far from satisfactory. At present, it is believed that the core mechanism of DAH post-HSCT is a vicious cycle initiated by endothelial injury, accompanied by a series of subsequent inflammatory and cellular responses.

[Efficacy and Safety of BeEAM, a Conditioning Regimen for Autologous Stem Cell Transplantation in Malignant Lymphoma].

Objective: To investigate the efficacy and safety of the conditioning regimen BeEAM (bendamustine+et-oposide+cytarabine+melphalan) in autologous stem cell transplantation (ASCT) for patients with malignant lymphoma.

Methods: The clinical data of 20 patients with malignant lymphoma who underwent ASCT after conditioning with BeEAM regimen from January 2021 to December 2022 in the First Affiliated Hospital of Bengbu Medical University were collected, and the clinical characteristics before transplantation, conditioning-related toxicity, hematopoietic reconstitution after transplantation, and therapeutic effects were analyzed. 67 patients with malignant lymphoma who did not undergo ASCT during the same period were selected as the control group, and the 1-year progression-free survival (PFS) rate and overall-survival (OS) rate between the ASCT group and the non-ASCT group were compared.

Novel strategy for hair regeneration: Exosomes and collagenous sequences of human a1(XVII) chain enhance hair follicle stem cell activity by regulating the hsa-novel-238a-CASP9 axis.

The regenerative capacity of hair follicles is fundamentally influenced by the intricate interactions between hair follicle stem cells (HFSCs) and their microenvironment. Our study presents a novel strategy for hair regeneration, highlighting the synergistic relationship between dermal papilla cell-derived exosomes (DPC-Exos) and collagenous sequences of Human a1(XVII) Chain (CS-COL17A1) in modulating HFSC activity via the hsa-novel-238a-CASP9 axis. We characterized DPC-Exos using nanoparticle tracking analysis and transmission electron microscopy and confirmed, their purity with the exosomal markers CD81, CD63, and CD9.

The comprehensive effects of varied photoperiods and algal abundance fluctuations on the key life history parameters of herbivorous rotifer Brachionus plicatilis.

The variation of photoperiod affects the photosynthesis of primary producer algae in the ocean, leading to fluctuations in algal abundance. The changes in photoperiod and algal abundance may have complex integrated effects on primary consumer herbivorous zooplankton. Therefore, in this study, we exposed two clones of rotifer Brachionus plicatilis to the combinations of five photoperiods (0 L: 24 D, 6 L: 18 D, 14 L: 10 D, 18 L: 6 D, and 24 L: 0 D) and three algal abundances (3 × 10, 10 × 10, and 100 × 10 cells mL) and recorded the key life history traits.

Regulating Integrin β1 to Restore Gonadotropin-Releasing Hormone-Tanycyte Unit Function in Polycystic Ovary Syndrome-Related Hypothalamic Dysregulation.

Excessive gonadotropin-releasing hormone (GnRH) is considered to be an initiating factor in the etiology of polycystic ovary syndrome (PCOS). GnRH neuronal axons terminate at the hypothalamic arcuate nucleus and median eminence, where tanycytes, specialized glial cells, have been proposed to modulate GnRH secretion through plasticity. However, the precise role of the "GnRH-tanycyte unit" during the pathological state of PCOS has not been thoroughly explored.

Activation of aryl hydrocarbon receptor attenuates intestinal inflammation by enhancing IRF4-mediated macrophage M2 polarization.

Background: Crohn's disease (CD) is characterized by immune cell dysregulation, with macrophages playing an indisputable role. Macrophages can exhibit opposing polarization under different conditions, resulting in pro- or anti-inflammatory effects. The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is implicated in intestinal inflammation by regulating both innate and adaptive immune responses.

Cultivating crayfish () significantly enhances the quantity and diversity of soil microorganisms: evidence from the comparison of rice-wheat and rice-crayfish rotation models.

Integrated farming of rice (IFA), as a time-honored agricultural model, can effectively increase agricultural productivity and provide ecological benefits. Rice-wheat rotation and rice-crayfish () rotation are two most widely applied IFA patterns in China. In this study, we compared the differences in soil microbial communities and predicted their functions in these two IFA models by sequencing the 16s rRNA and analyzing the bioinformation.

The IRF2-INPP4B pathway is activated in CD4+ T cells and aggravates acute myeloid leukemia development by inhibiting apoptosis.

Background: Interferon-regulatory factor 2 (IRF2)/inositol polyphosphate 4-phosphatase B (INPP4B) is essential for the differentiation of immune T cells. However, the regulatory mechanism of IRF2/INPP4B signaling pathway on apoptosis of acute myeloid leukemia (AML) cells remains unclear. Thus, this study intended to investigate the function and mechanism of IRF2/INPP4B in the development of AML.

The influence of mutually beneficial and self-beneficial situations on the lying behavior and cognition of Chinese 4- to 5-year-old children.

Background: Children's moral development is influenced by their sociocultural context. However, relatively few studies have investigated whether the sociocultural context affects children's lying behavior and cognition and the relation between them.

Methods: The present study was designed to examine this question in two experiments by posing two moral dilemmas: lying is good for mutually beneficial (honesty conflicts with mutual interests) and lying is good for self-beneficial (honesty conflicts with self-interests).

Large language models for diabetes training: a prospective study.

Diabetes poses a considerable global health challenge, with varying levels of diabetes knowledge among healthcare professionals, highlighting the importance of diabetes training. Large Language Models (LLMs) provide new insights into diabetes training, but their performance in diabetes-related queries remains uncertain, especially outside the English language like Chinese. We first evaluated the performance of ten LLMs: ChatGPT-3.

Correlations of Gelling Properties and 3D Printability to the Chemical Composition and Rheological Properties of Surimi from Different Marine Fish Species.

Samples of marine surimi made from six different fish types have been comprehensively investigated and compared in terms of chemical composition, protease activity, gelling chemistry, gel properties and 3D printability. It has been found that surimi with high protein content, low fat concentration, low activity of endogenous protease (cathepsin B, cathepsin L, cathepsin D, calpain and serine protease) and low TVB-N showed better gelling capacity and gel properties. However, the 3D printability of surimi was more relevant to apparent viscosity.

Instantaneous Self-Healing Chitosan Hydrogels with Enhanced Drug Leakage Resistance for Infected Stretchable Wounds Healing.

Self-healing hydrogels are intelligent wound dressings to repair structural damage caused by limb movement, demonstrating advantages in stretchable wound management. Chitosan is widely used in the preparation of hydrogels due to the biocompatibility and biodegradability. However, the self-healing efficiency and mechanical strength of chitosan hydrogels are not ideal.

Therapeutic potential of recombinant human type XVII collagen in wound healing and bullous pemphigoid: From bench to bedside.

Objective: To investigate the effects of recombinant human type XVII collagen (RHCXVII) on the proliferation and adhesion of primary human keratinocytes (HPKCs) and to observe its clinical efficacy and safety in bullous pemphigoid (BP).

Methods: The RHCXVII was produced by genetic recombination technology and characterized by Fourier transform infrared (FTIR) spectroscopy. HPKCs were obtained from human foreskin and seeded onto culture plates coated with RHCXVII at concentrations of 10, 50 and 100μg/ml.

Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH-tanycyte unit function of polycystic ovary syndrome.

Background: Polycystic ovary syndrome (PCOS) is a complex neuroendocrine disorder characterized by dysregulation of the hypothalamus. Both electroacupuncture (EA) and manual acupuncture (MA) have demonstrated therapeutic efficacy in the treatment of PCOS through improvements in hypothalamic function. However, the underlying mechanisms remain poorly understood.

A Multidisciplinary Multimodal Aligned Dataset for Academic Data Processing.

Academic data processing is crucial in scientometrics and bibliometrics, such as research trending analysis and citation recommendation. Existing datasets in this domain have predominantly concentrated on textual data, overlooking the importance of visual elements. To bridge this gap, we introduce a multidisciplinary multimodal aligned dataset (MMAD) specifically designed for academic data processing.

Determination of 36 non-phthalate plasticizers with the QuEChERS method in milk powder by gas chromatography coupled with quadrupole/orbitrap high-resolution mass spectrometry.

A method involving gas chromatography coupled with quadrupole/orbitrap high-resolution mass spectrometry (GC-Q/Orbitrap HRMS) with the QuEChERS method was developed to analyze 36 non-phthalate plasticizers in milk powder products. The samples were dissolved in 20% NaCl, extracted with acetonitrile, and purified using silica, PSA, and C. The results showed the excellent linear relationship of the calibration curves of 36 non-phthalate plasticizers in the range of 10-1000 ng mL, with correlation coefficients () not less than 0.

Dermal fibroblast-derived extracellular matrix (ECM) synergizes with keratinocytes in promoting re-epithelization and scarless healing of skin wounds: Towards optimized skin tissue engineering.

Skin serves as the first-order protective barrier against the environment and any significant disruptions in skin integrity must be promptly restored. Despite significant advances in therapeutic strategies, effective management of large chronic skin wounds remains a clinical challenge. Dermal fibroblasts are the primary cell type responsible for remodeling the extracellular matrix (ECM) in wound healing.

The ASPARAGINE-RICH PROTEIN-LYST-INTERACTING PROTEIN5 complex regulates noncanonical AUTOPHAGY8 degradation in Arabidopsis.

The endocytic and autophagic pathways play important roles in abiotic stress responses and maintaining cellular homeostasis in plants. Asparagine-rich proteins (NRPs) are plant-specific, stress-responsive proteins that are involved in many abiotic stress-related signaling pathways. We previously demonstrated that NRP promotes PIN FORMED 2 (PIN2) vacuolar degradation to maintain PIN2 homeostasis under abscisic acid treatment in Arabidopsis (Arabidopsis thaliana).